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Nohynek, G.J. (author), Skare, J.A. (author), Meuling, W.J.A. (author), Wehmeyer, K.R. (author), de Bie, A.T.H.J. (author), Vaes, W.H.J. (author), Dufour, E.K. (author), Fautz, R. (author), Steiling, W. (author), Bramante, M. (author), Toutain, H. (author)Systemic exposure was measured in humans after hair dyeing with oxidative hair dyes containing 2.0% (A) or 1.0% (B) [14C]-p-phenylenediamine (PPD). Hair was dyed, rinsed, dried, clipped and shaved; blood and urine samples were collected for 48 hours after application. [14C] was measured in all materials, rinsing water, hair, plasma, urine and...article 2015
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Reinen, J. (author), Nematollahi, L. (author), Fidder, A. (author), Vermeulen, N.P.E. (author), Noort, D. (author), Commandeur, J.N.M. (author)Tri-ortho-cresyl phosphate (ToCP) is a multipurpose organophosphorus compound that is neurotoxic and suspected to be involved in aerotoxic syndrome in humans. It has been reported that not ToCP itself but a metabolite of ToCP, namely, 2-(ortho-cresyl)-4H-1,2,3-benzodioxaphosphoran-2-one (CBDP), may be responsible for this effect as it can...article 2015
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Bosgra, S. (author), Westerhout, J. (author)In the EU collaborative project ChemScreen an alternative, in vitro assay-based test strategy was developed to screen compounds for reproductive toxicity. A toxicokinetic modeling approach was used to allow quantitative comparison between effective concentrations in the in vitro test battery and observations of developmental toxicity in vivo....article 2015
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Van der Burg, B. (author), Wedebye, E.B. (author), Dietrich, D.R. (author), Jaworska, J. (author), Mangelsdorf, I. (author), Paune, E. (author), Schwarz, M. (author), Piersma, A.H. (author), Kroese, E.D. (author)There is a great need for rapid testing strategies for reproductive toxicity testing, avoiding animal use.The EU Framework program 7 project ChemScreen aimed to fill this gap in a pragmatic manner prefer-ably using validated existing tools and place them in an innovative alternative testing strategy. In ourapproach we combined knowledge on...article 2015
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Bodin, J. (author), Kocbach Bølling, A. (author), Wendt, A. (author), Eliasson, L. (author), Becher, R. (author), Kuper, F. (author), Løvik, M. (author), Nygaard, U.C. (author)Type 1 diabetes mellitus (T1DM) is an autoimmune destruction of insulin producing pancreatic beta-cells due to a genetic predisposition and can be triggered by environmental factors. We have previously shown that bisphenol A (BPA) accelerates the spontaneous development of diabetes in non-obese diabetic (NOD) mice. Here, we hypothesized that...article 2015
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Louisse, J. (author), Bosgra, S. (author), Blaauboer, B.J. (author), Rietjens, I.M.C.M. (author), Verwei, M. (author)The use of laboratory animals for toxicity testing in chemical safety assessment meets increasing ethical, economic and legislative constraints. The development, validation and application of reliable alternatives for in vivo toxicity testing are therefore urgently needed. In order to use toxicity data obtained from in vitro assays for risk...article 2015
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- de Groot, D.M.G. (author), Westerink, R.H.S. (author), Lammers, J.H.C.M. (author), Fox, D.A. (author), van Thriel, C. (author), Llorens, J. (author) article 2014
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Schaudien, D. (author), Harleman, H. (author), Bouallala, F. (author), Kuper, C.F. (author)Toxicologic pathology plays a crucial role in the identification and interpretation of substance-induced health effects. Histology of lymphoid organs is quite sensitive, although it does not flag every model immunotoxic substance. Subtle interferences of toxic compounds, like transmembrane signaling and cell activation, are often not detectable...bookPart 2014
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Fostel, J. (author), van Someren, E. (author), Pronk, T. (author), Pennings, J. (author), Schmeits, P. (author), Shao, J. (author), Kroese, D. (author), Stierum, R. (author)Systems toxicology relies on data integration from a variety of disciplines. These include the toxicological phenotype and in vitro assay data, together with a system-wide response such as transcriptomics data. To facilitate this, databases to capture a variety of phenotypic data, along with so-called 'omics data and metadata describing the...bookPart 2014
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Leeman, W.R. (author), Krul, L. (author), Houben, G.F. (author)The threshold of toxicological concern (TTC) concept is a risk assessment tool for substances present at low oral exposure and lacking hazard data. In the past, several thresholds were elaborated by Munro et al. (1996) and Kroes et al. (2004). For these TTC thresholds, the Cramer class III threshold is based on a broad spectrum of substances,...article 2014
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Reus, A.A. (author), Maas, W.J.M. (author), Jansen, H.T. (author), Constant, S. (author), Staal, Y.C.M. (author), van Triel, J.J. (author), Kuper, C.F. (author)The respiratory route is an important portal for human exposure to a large variety of substances. Consequently, there is an urgent need for realistic in vitro strategies for evaluation of the absorption of airborne substances with regard to safety and efficacy assessment. The present study investigated feasibility of a 3D human airway epithelial...article 2014
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Kleensang, A. (author), Maertens, A. (author), Rosenberg, M. (author), Fitzpatrick, S. (author), Lamb, J. (author), Auerbach, S. (author), Brennan, R. (author), Crofton, K.M. (author), Gordon, B. (author), Fornace Jr., A.J. (author), Gaido, K. (author), Gerhold, D. (author), Haw, R. (author), Henney, A. (author), Ma’ayan, A. (author), McBride, M. (author), Monti, S. (author), Ochs, M.F. (author), Pandey, A. (author), Sharan, R. (author), Stierum, R. (author), Tugendreich, Z. (author), Willett, C. (author), Wittwehr, C. (author), Xia, J. (author), Patton, G.W. (author), Arvidson, K. (author), Bouhifd, M. (author), Hogberg, H.T. (author), Luechtefeld, T. (author), Smirnova, L. (author), Zhao, L. (author), Adeleye, Y. (author), Kanehisa, M. (author), Carmichael, P. (author), Andersen, M.E. (author), Hartung, T. (author)Despite wide-spread consensus on the need to transform toxicology and risk assessment in order to keep pace with technological and computational changes that have revolutionized the life sciences, there remains much work to be done to achieve the vision of toxicology based on a mechanistic foundation. A workshop was organized to explore one key...article 2014
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Patlewicz, G. (author), Ball, N. (author), Becker, R.A. (author), Booth, E.D. (author), Cronin, M.T.D. (author), Kroese, D. (author), Steup, D. (author), van Ravenzwaay, B. (author), Hartung, T. (author)Read-across is a data gap filling technique used within category and analogue approaches. It has been utilized as an alternative approach to address information requirements under various past and present regulatory programs such as the OECD High Production Volume Programme as well as the EU's Registration, Evaluation, Authorisation and...article 2014
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Koster, S. (author), Rennen, M. (author), Leeman, W. (author), Houben, G. (author), Muilwijk, B. (author), van Acker, F. (author), Krul, L. (author)One of the main challenges in food contact materials research is to prove that the presence of non-intentionally added substances (NIAS) is not a safety issue. Migration extracts may contain many unknown substances present at low concentrations. It is difficult and time-consuming to identify all these potential NIAS and concurrently to assess...article 2014
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- Prinsen, M.K. (author) doctoral thesis 2014
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- Louisse, J. (author), Bosgra, S. (author), Blaauboer, B.J. (author), Rietjens, Y.M.C.M. (author), Verwei, M. (author) article 2014
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- Rijnkels, J. (author), Terwoert, J. (author) article 2014
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Ramirez, T. (author), Daneshian, M. (author), Kamp, H. (author), Bois, F.Y. (author), Clench, M.R. (author), Coen, M. (author), Donley, B. (author), Fischer, S.M. (author), Ekman, D.R. (author), Fabian, E. (author), Guillou, C. (author), Heuer, J. (author), Hogberg, H.T. (author), Jungnickel, H. (author), Keun, H.C. (author), Krennrich, G. (author), Krupp, E. (author), Luch, A. (author), Noor, F. (author), Peter, E. (author), Riefke, B. (author), Seymour, M. (author), Skinner, N. (author), Smirnova, L. (author), Verheij, E. (author), Wagner, S. (author), Hartung, T. (author), van Ravenzwaay, B. (author), Leist, M. (author)Metabolomics, the comprehensive analysis of metabolites in a biological system, provides detailed information about the biochemical/physiological status of a biological system, and about the changes caused by chemicals. Metabolomics analysis is used in many fields, ranging from the analysis of the physiological status of genetically modified...article 2013
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Solecki, R. (author), Barbellion, S. (author), Bergmann, B. (author), Bürgin, H. (author), Buschmann, J. (author), Clark, R. (author), Comotto, L. (author), Fuchs, A. (author), Faqi, A.S. (author), Gerspach, R. (author), Grote, K. (author), Hakansson, H. (author), Heinrich, V. (author), Heinrich-Hirsch, B. (author), Hofmann, T. (author), Hübel, U. (author), Inazaki, T.H. (author), Khalil, S. (author), Knudsen, T.B. (author), Kudicke, S. (author), Lingk, W. (author), Makris, S. (author), Müller, S. (author), Paumgartten, F. (author), Pfeil, R. (author), Rama, E.M. (author), Schneider, S. (author), Shiota, K. (author), Tamborini, E. (author), Tegelenbosch, M. (author), Ulbrich, B. (author), van Duijnhoven, E.A.J. (author), Wise, D. (author), Chahoud, I. (author)This article summarizes the 7th Workshop on the Terminology in Developmental Toxicology held in Berlin, May 4-6, 2011. The series of Berlin Workshops has been mainly concerned with the harmonization of terminology and classification of fetal anomalies in developmental toxicity studies. The main topics of the 7th Workshop were knowledge on the...article 2013
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Beker van Woudenberg, A. (author), Wolterbeek, A. (author), te Brake, L. (author), Snel, C. (author), Menke, A. (author), Rubingh, C. (author), de Groot, D. (author), Kroese, D. (author)Zebrafish embryos were exposed to different organotin compounds during very early development (<100. h post fertilization). Morphology, histopathology and swimming activity (in a motor activity test) were the endpoints analyzed. DBTC was, by far, the most embryotoxic compound at all time points and endpoints studied. In fact, we observed a clear...article 2013