Searched for: subject%3A%22Toxicity%255C%2Btesting%22
(101 - 107 of 107)

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document
Zwart, A. (author), Arts, J.H.E. (author), ten Berge, W.F. (author), Appelman, L.M. (author)
A new design for acute inhalation toxicity testing was evaluated and compared with results obtained according to OECD guideline 403. The new design consists of a range-finding test, which is compatible with a conventional limit test, and can be followed by determination of a concentration-time-mortality relationship, enabling calculation of LC50...
article 1992
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Rutten, A.A.J.J.L. (author), Bequet-Passelecq, B.G.A.G.G. (author), Koeter, H.B.W.M. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
A new method was developed for rabbit skin organ culture. In a two-compartment model, skin discs were cultured on a Millicell-HA insert unit with a microporous membrane which allows transport of culture medium via the dermis into the epidermis, whereas the epidermal side remains free of direct contact with culture medium. In this relatively...
article 1990
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Kulig, B.M. (author)
article 1989
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de Groot, A.P. (author), Feron, V.J. (author), Immel, H.R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
In previous studies we observed an increased incidence of hyperplasia in the epithelium of the urinary bladder of rats fed cereal-based stock diet supplemented with 6% monosodium glutamate (MSG) for 3 months. Hyperplasia was not enhanced, however, when 6% MSG was fed in a purified casein diet. Further studies have been conducted to identify the...
article 1988
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Feron, V.J. (author), Kroes, R. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
Despite increasing standardisation and international harmonisation of the long-term carcinogenicity study in rodents there are still areas of controversy such as high-dose selection, duration of the test period, combining or not combining the chronic toxicity and the carcinogenicity study, the use of historical control data, conditions for...
article 1986
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Appelman, L.M. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The toxicity data of 66 compounds adequately tested in the rat (as 'prime animal species') and in the dog (as 'second animal species') were studied to find out for how many of these compounds the study in dogs led to a lower 'no-toxic-effect level' (NTEL) than that found in the rat. From a quantitative point of view such information would...
article 1986
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Ko√ęter, H.B.W.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Toxicity data of 37 compounds tested in both a subchronic study and one or more studies focused on reproduction were evaluated to obtain information on the significance of fertility and reproduction parameters in setting no-effect levels (NEL). It appeared that a) the test system aimed at reproduction and development was more sensitive than the...
article 1983
Searched for: subject%3A%22Toxicity%255C%2Btesting%22
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