- document
-
van der Zande, M. (author), Vandebriel, R.J. (author), Groot, M.J. (author), Kramer, E. (author), Herrera Rivera, Z.E. (author), Rasmussen, K. (author), Ossenkoppele, J.S. (author), Tromp, P. (author), Gremmer, E.R. (author), Peters, R.J.B. (author), Hendriksen, P.J. (author), Marvin, H.J.P. (author), Hoogenboom, R.L.A.P. (author), Peijnenburg, A.A.C.M. (author), Bouwmeester, H. (author)Background: Synthetic Amorphous Silica (SAS) is commonly used in food and drugs. Recently, a consumer intake of silica from food was estimated at 9.4 mg/kg bw/day, of which 1.8 mg/kg bw/day was estimated to be in the nano-size range. Food products containing SAS have been shown to contain silica in the nanometer size range (i.e. 5 - 200 nm) up...article 2014
- document
-
Bodin, J. (author), Bølling, A.B. (author), Becher, R. (author), Kuper, F. (author), Løvik, M. (author), Nygaard, U.C. (author)Diabetes mellitus type 1 is an autoimmune disease with a genetic predisposition that is triggered by environmental factors during early life. Epidemiological studies show that bisphenol A (BPA), an endocrine disruptor, has been detected in about 90% of all analyzed human urine samples. In this study, BPA was found to increase the severity of...article 2014
- document
-
Kleensang, A. (author), Maertens, A. (author), Rosenberg, M. (author), Fitzpatrick, S. (author), Lamb, J. (author), Auerbach, S. (author), Brennan, R. (author), Crofton, K.M. (author), Gordon, B. (author), Fornace Jr., A.J. (author), Gaido, K. (author), Gerhold, D. (author), Haw, R. (author), Henney, A. (author), Ma’ayan, A. (author), McBride, M. (author), Monti, S. (author), Ochs, M.F. (author), Pandey, A. (author), Sharan, R. (author), Stierum, R. (author), Tugendreich, Z. (author), Willett, C. (author), Wittwehr, C. (author), Xia, J. (author), Patton, G.W. (author), Arvidson, K. (author), Bouhifd, M. (author), Hogberg, H.T. (author), Luechtefeld, T. (author), Smirnova, L. (author), Zhao, L. (author), Adeleye, Y. (author), Kanehisa, M. (author), Carmichael, P. (author), Andersen, M.E. (author), Hartung, T. (author)Despite wide-spread consensus on the need to transform toxicology and risk assessment in order to keep pace with technological and computational changes that have revolutionized the life sciences, there remains much work to be done to achieve the vision of toxicology based on a mechanistic foundation. A workshop was organized to explore one key...article 2014
- document
-
Patlewicz, G. (author), Ball, N. (author), Becker, R.A. (author), Booth, E.D. (author), Cronin, M.T.D. (author), Kroese, D. (author), Steup, D. (author), van Ravenzwaay, B. (author), Hartung, T. (author)Read-across is a data gap filling technique used within category and analogue approaches. It has been utilized as an alternative approach to address information requirements under various past and present regulatory programs such as the OECD High Production Volume Programme as well as the EU's Registration, Evaluation, Authorisation and...article 2014
- document
-
Beker van Woudenberg, A. (author), Snel, C. (author), Rijkmans, E. (author), de Groot, D. (author), Bouma, M. (author), Hermsen, S. (author), Piersma, A. (author), Menke, A. (author), Wolterbeek, A. (author)To improve the predictability of the zebrafish embryotoxicity test (ZET) for developmental (neuro)toxicity screening, we used a multiple-endpoints strategy, including morphology, motor activity (MA), histopathology and kinetics. The model compounds used were antiepileptic drugs (AEDs): valproic acid (VPA), carbamazepine (CBZ), ethosuximide (ETH)...article 2014
- document
-
Gozalpour, E. (author), Greupink, R. (author), Wortelboer, H.M. (author), Bilos, A. (author), Schreurs, M. (author), Russel, F.G.M. (author), Koenderink, J.B. (author)Digitalis-like compounds (DLCs) such as digoxin, digitoxin, and ouabain, also known as cardiac glycosides, are among the oldest pharmacological treatments for heart failure. The compounds have a narrow therapeutic window, while at the same time, DLC pharmacokinetics is prone to drug-drug interactions at the transport level. Hepatic transporters...article 2014
- document
-
Meunier, L. (author), Garthoff, J.A. (author), Schaafsma, A. (author), Krul, L. (author), Schrijver, J. (author), van Goudoever, J.B. (author), Speijers, G. (author), Vandenplas, Y. (author)Locust bean gum (LBG) is a galactomannan polysaccharide used as thickener in infant formulas with the therapeutic aim to treat uncomplicated gastroesophageal reflux (GER). Since its use in young infants below 12. weeks of age is not explicitly covered by the current scientific concept of the derivation of health based guidance values, the...article 2014
- document
- Louisse, J. (author), Bosgra, S. (author), Blaauboer, B.J. (author), Rietjens, Y.M.C.M. (author), Verwei, M. (author) article 2014
- document
-
van der Veen, J.W. (author), Soeteman-Hernández, L.G. (author), Ezendam, J. (author), Stierum, R. (author), Kuper, F.C. (author), van Loveren, H. (author)Allergic contact dermatitis (ACD) is a hypersensitivity immune response induced by small protein-reactive chemicals. Currently, the murine local lymph node assay (LLNA) provides hazard identification and quantitative estimation of sensitizing potency. Given the complexity of ACD, a single alternative method cannot replace the LLNA, but it is...article 2014
- document
-
Zimmer, B. (author), Pallocca, G. (author), Dreser, N. (author), Foerster, S. (author), Waldmann, T. (author), Westerhout, J. (author), Julien, S. (author), Krause, K.H. (author), van Thriel, C. (author), Hengstler, J.G. (author), Sachinidis, A. (author), Bosgra, S. (author), Leist, M. (author)Developmental toxicity in vitro assays have hitherto been established as stand-alone systems, based on a limited number of toxicants. Within the embryonic stem cell-based novel alternative tests project, we developed a test battery framework that allows inclusion of any developmental toxicity assay and that explores the responses of such test...article 2014
- document
-
Beker van Woudenberg, A. (author), Wolterbeek, A. (author), te Brake, L. (author), Snel, C. (author), Menke, A. (author), Rubingh, C. (author), de Groot, D. (author), Kroese, D. (author)Zebrafish embryos were exposed to different organotin compounds during very early development (<100. h post fertilization). Morphology, histopathology and swimming activity (in a motor activity test) were the endpoints analyzed. DBTC was, by far, the most embryotoxic compound at all time points and endpoints studied. In fact, we observed a clear...article 2013
- document
-
Leeman, W.R. (author), Krul, L. (author), Houben, G.F. (author)Upon analysis of chemically complex food matrices a forest of peaks is likely to be found. Identification of these peaks and concurrent determination of the toxicological relevance upon exposure is very time consuming, expensive and often requires animal studies. Recently, a safety assessment framework based on the Threshold of Toxicological...article 2013
- document
-
Tonk, E.C.M. (author), de Groot, D.M.G. (author), Wolterbeek, A.P.M. (author), Penninks, A.H. (author), Waalkens-Berendsen, I.D.H. (author), Piersma, A.H. (author), van Loveren, H. (author)The susceptibility of developing immune system to chemical disruption warrants the assessment of immune parameters in reproductive and developmental testing protocols. In this study, a wide range of immune endpoints was included in an extended one-generation reproduction toxicity study (EOGRTS) design to determine the relative sensitivity of...article 2013
- document
-
Krug, A.K. (author), Kolde, R. (author), Gaspar, J.A. (author), Rempel, E. (author), Balmer, N.V. (author), Meganathan, K. (author), Vojnits, K. (author), Baquié, M. (author), Waldmann, T. (author), Ensenat-Waser, R. (author), Jagtap, S. (author), Evans, R.M. (author), Julien, S. (author), Peterson, H. (author), Zagoura, D. (author), Kadereit, S. (author), Gerhard, D. (author), Sotiriadou, I. (author), Heke, M. (author), Natarajan, K. (author), Henry, M. (author), Winkler, J. (author), Marchan, R. (author), Stoppini, L. (author), Bosgra, S. (author), Westerhout, J. (author), Verwei, M. (author), Vilo, J. (author), Kortenkamp, A. (author), Hescheler, J. (author), Hothorn, L. (author), Bremer, S. (author), van Thriel, C. (author), Krause, K.-H. (author), Hengstler, J.G. (author), Rahnenführer, J. (author), Leist, M. (author), Sachinidis, A. (author)Developmental neurotoxicity (DNT) and many forms of reproductive toxicity (RT) often manifest themselves in functional deficits that are not necessarily based on cell death, but rather on minor changes relating to cell differentiation or communication. The fields of DNT/RT would greatly benefit from in vitro tests that allow the identification...article 2013
- document
- de Klerk, W.P.C. (author), van Hulst, M. (author), Langenberg, J.P. (author) conference paper 2013
- document
-
van Hulst, M. (author), de Klerk, W.P.C. (author), Langenberg, J.P. (author), Tuinman, I.L. (author), Alblas, M.J. (author)Exposure to signaling smoke is almost impossible to avoid, and may have adverse health effects. Hand grenades with signaling smoke are used during training and/or military operations. To obtain the most realistic results when estimating the toxicity of the smoke, not only the smoke–forming composition is ignited, but the whole hand grenade is...conference paper 2013
- document
-
Destexhe, E. (author), Prinsen, M.K. (author), van Schöll, I. (author), Kuper, C.F. (author), Garçon, N. (author), Veenstra, S. (author), Segal, L. (author)Introduction: Inflammatory reactions are one of the potential safety concerns that are evaluated in the framework of vaccine safety testing. In nonclinical studies, the assessment of the inflammation relies notably on the measurement of biomarkers. C-reactive protein (CRP) is an acute-phase plasma protein of hepatic origin that could be used for...article 2013
- document
-
Hettne, K.M. (author), Boorsma, A. (author), van Dartel, D.A.M. (author), Goeman, J.J. (author), de Jong, E. (author), Piersma, A.H. (author), Stierum, R.H. (author), Kleinjans, J.C. (author), Kors, J.A. (author)Background: Availability of chemical response-specific lists of genes (gene sets) for pharmacological and/or toxic effect prediction for compounds is limited. We hypothesize that more gene sets can be created by next-generation text mining (next-gen TM), and that these can be used with gene set analysis (GSA) methods for chemical treatment...article 2013
- document
-
Strikwold, M. (author), Woutersen, R.A. (author), Spenkelink, B. (author), Punt, A. (author), Rietjens, I.M.C.M. (author)The applicability of the embryonic stem cell test (EST) as an alternative for in vivo embryotoxicity testing was evaluated for a series of five p-substituted phenols. To this purpose, the potency ranking for this class of compounds derived from the inhibition of cardiomyocyte differentiation in the EST was compared to in vivo embryotoxic potency...article 2012
- document
-
de Esch, C. (author), Slieker, R. (author), Wolterbeek, A. (author), Woutersen, R. (author), de Groot, D. (author)The zebrafish is a powerful toxicity model; biochemical assays can be combined with observations at a structural and functional level within one individual. This mini review summarises the potency of zebrafish as a model for developmental neurotoxicity screening, and its possibilities to investigate working mechanisms of toxicants. The use of...article 2012