Searched for: subject%3A%22Toxicity%22
(1 - 20 of 307)

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Jeliazkova, N. (author), Apostolova, M.D. (author), Andreoli, C. (author), Barone, F. (author), Barrick, A. (author), Battistelli, C. (author), Bossa, C, (author), Botea-Petcu, A. (author), Châtel, A. (author), De Angelis, I. (author), Dusinska, M. (author), El Yamani, N. (author), Gheorghe, D. (author), Giusti, A. (author), Gómez-Fernández, P. (author), Grafström, R. (author), Gromelski, M. (author), Jacobsen, N.R. (author), Jeliazkov, V. (author), Jensen, K.A. (author), Kochev, N. (author), Kohonen, P. (author), Manier, N. (author), Mariussen, (author), Mech, A. (author), Navas, J.M. (author), Paskaleva, V. (author), Precupas, A. (author), Puzyn, T. (author), Rasmussen, K. (author), Ritchie, P. (author), Llopis, I.R. (author), Rundén-Pran, E. (author), Sandu, R. (author), Shandilya, N. (author), Tanasescu, S. (author), Haase, A. (author), Nymark, P. (author)
Nanotechnology is a key enabling technology with billions of euros in global investment from public funding, which include large collaborative projects that have investigated environmental and health safety aspects of nanomaterials, but the reuse of accumulated data is clearly lagging behind. Here we summarize challenges and provide...
article 2021
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Gorzkowska-Sobas, A.A. (author), Blindheim Lausund, K. (author), de Koning, M.C. (author), Petrovic, V. (author), Chavan, S.M. (author), Smith, M.W. (author), Nilsen, O. (author)
Metal–organic frameworks (MOFs) are a class of porous organic-inorganic solids extensively explored for numerous applications owing to their catalytic activity and high surface area. In this work MOF thin films deposited in a one-step, molecular layer deposition (MLD), an all-gas-phase process, on glass wool fibers are characterized by X-ray...
article 2021
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Kim, Y.H. (author), Warren, S.H. (author), Kooter, I. (author), Williams, W.C. (author), George, I.J. (author), Vance, S.A. (author), Hays, M.D. (author), Higuchi, M.A. (author), Gavett, S.H. (author), DeMarini, D.M. (author), Jaspers, I. (author), Gilmour, M.I. (author)
Abstract Background: Open burning of anthropogenic sources can release hazardous emissions and has been associated with increased prevalence of cardiopulmonary health outcomes. Exposure to smoke emitted from burn pits in mili tary bases has been linked with respiratory illness among military and civilian personnel returning from war zones....
article 2021
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Verheij, E.R. (author), Joosen, M.J.A. (author), Cochrane, L. (author), de Bruin-Hoegée, J.M. (author), de Koning, M.C. (author)
Purpose: This study investigated the decontamination effectiveness of selected toxic industrial chemicals using RSDL® (Reactive Skin Decontamination Lotion Kit; Emergent BioSolutions Inc.; https://www.rsdl.com/). Materials and Methods: Quantitative analytical methods were developed for dermal toxic compounds of varying physicochemical properties...
article 2020
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Vink, J.P.M. (author), Comans, R.N.J. (author), Dijkstra, J.J. (author), Lamers, L.P.M. (author)
article 2020
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van den Dries, M.A. (author), Guxens, M. (author), Spaan, S. (author), Ferguson, K.K. (author), Philips, E. (author), Santos, S. (author), Jaddoe, V.W.V. (author), Ghassabian, A. (author), Trasande, L. (author), Tiemeier, H. (author), Pronk, A. (author)
BACKGROUND: Prenatal exposures to phthalates and bisphenols are associated with impaired brain development in animals. However, epidemiological studies investigating the association between prenatal phthalate or bisphenol exposure and cognition have produced mixed findings and mostly had modest sample sizes and measured the exposure during the...
article 2020
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Sewell, F. (author), Strupp, C. (author), van der Laan, J.W. (author), Wolf, D.C. (author), Wolterink, G. (author), Woutersen, R. (author), Zvonar, Z. (author), Heusinkveld, H. (author), Braakhuis, H. (author)
Currently the only methods for non-genotoxic carcinogenic hazard assessment accepted by most regulatory authorities are lifetime carcinogenicity studies. However, these involve the use of large numbers of animals and the relevance of their predictive power and results has been scientifically challenged. With increased availability of innovative...
article 2020
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Byrne, F.P. (author), Nussbaumer, C.M. (author), Savin, E.J. (author), Milescu, R.A. (author), McElroy, C.R. (author), Clark, J.H. (author), van Vugt-Lussenburg, B.M.A. (author), van der Burg, B. (author), Meima, M.Y. (author), Buist, H.E. (author), Kroese, E.D. (author), Hunt, A.J. (author), Farmer, T.J. (author)
Three dipolar aprotic solvents were designed to possess high dipolarity and low toxicity: N,N,N′,N′-tetrabutylsuccindiamide (TBSA), N,N′-diethyl-N,N′-dibutylsuccindiamide (EBSA), and N,N′-dimethyl-N,N′-dibutylsuccindiamide (MBSA). They were synthesized catalytically by using a K60 silica catalyst in a solventless system. Their water...
article 2020
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Gelbke, H.P. (author), Buist, H. (author), Eisert, R. (author), Leibold, E. (author), Sherman, J. (author)
Polyoxymethylene (POM) is a polymer of formaldehyde used inter alia for kitchenware and food processing machines. By migration into food, consumers may be exposed to small additional amounts of formaldehyde in food. In order to address such potential exposures, Specific Migration Limits are derived using all studies with oral exposure in mammals...
article 2019
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Desprez, B. (author), Birk, B. (author), Blaauboer, B. (author), Boobis, A. (author), Carmichael, P. (author), Cronin, M.T.D. (author), Curie, R. (author), Daston, G. (author), Hubesch, B. (author), Jennings, P. (author), Klaric, M. (author), Kroese, D. (author), Mahony, C. (author), Ouédraogo, G. (author), Piersma, A. (author), Richarz, A.N. (author), Schwarz, M. (author), van Benthem, J. (author), van de Water, B. (author), Vinken, M. (author)
Repeated dose toxicity evaluation aims at assessing the occurrence of adverse effects following chronic or repeated exposure to chemicals. Non-animal approaches have gained importance in the last decades because of ethical considerations as well as due to scientific reasons calling for more human-based strategies. A critical aspect of this...
article 2019
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Bitzer, J. (author), Henkel, T. (author), Nikiforov, A.I. (author), Rihner, M.O. (author), Verspeek-Rip, C.M. (author), Usta, B. (author), van den Wijngaard, M. (author)
A series of in vitro studies were conducted to assess the genetic toxicity of jelly mushroom glycolipids from Dacryopinax spathularia (herein referred to as “AM-1“). In the bacterial reverse mutation assay (Ames test), there was no evidence of mutagenic activity in any Salmonella typhimurium strains tested or in Escherichia coli strain WP2uvrA,...
article 2019
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Graepel, R. (author), ter Braak, B. (author), Escher, S.E. (author), Fisher, C. (author), Gardner, I. (author), Kamp, H. (author), Kroese, D. (author), Leist, M. (author), Moné, M.J. (author), Pastor, M. (author), van de Water, B. (author)
The EU-ToxRisk research project is an interdisciplinary research project that aims to advance the paradigm shift in toxicology towards new approach methodology (NAM)–based approaches for risk assessment. In this European research project, experts in the fields of in vitro and in silico techniques and risk assessment from academia, industry and...
article 2019
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Escher, S.E. (author), Kamp, H. (author), Bennekou, S.H. (author), Bitsch, A. (author), Fisher, C. (author), Graepel, R. (author), Hengstler, J.G. (author), Herzler, M. (author), Knight, D. (author), Leist, M. (author), Norinder, U. (author), Ouédraogo, G. (author), Pastor, M. (author), Stuard, S. (author), White, A. (author), Zdrazil, B. (author), van de Water, B. (author), Kroese, D. (author)
Read-across is one of the most frequently used alternative tools for hazard assessment, in particular for complex endpoints such as repeated dose or developmental and reproductive toxicity. Read-across extrapolates the outcome of a specific toxicological in vivo endpoint from tested (source) compounds to “similar” (target) compound(s). If...
article 2019
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Braakhuis, H.M. (author), Slob, W. (author), Olthof, E.D. (author), Wolterink, G. (author), Zwart, E.P. (author), Gremmer, E.R. (author), Rorije, E. (author), van Benthem, J. (author), Woutersen, R. (author), van der Laan, J.W. (author), Luijten, M. (author)
Non-genotoxic carcinogens (NGTXCs) do not cause direct DNA damage but induce cancer via other mechanisms. In risk assessment of chemicals and pharmaceuticals, carcinogenic risks are determined using carcinogenicity studies in rodents. With the aim to reduce animal testing, REACH legislation states that carcinogenicity studies are only allowed...
article 2018
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Leist, M. (author), Ghallab, A. (author), Graepel, R. (author), Marchan, R. (author), Hassan, R. (author), Bennekou, S.H. (author), Limonciel, A. (author), Vinken, M. (author), Schildknecht, S. (author), Waldmann, T. (author), Danen, E. (author), van Ravenzwaay, B. (author), Kamp, H. (author), Gardner, I. (author), Godoy, P. (author), Bois, F.Y. (author), Braeuning, A. (author), Reif, R. (author), Oesch, F. (author), Drasdo, D. (author), Höhme, S. (author), Schwarz, M. (author), Hartung, T. (author), Braunbeck, T. (author), Beltman, J. (author), Vrieling, H. (author), Sanz, F. (author), Forsby, A. (author), Gadaleta, D. (author), Fisher, C. (author), Kelm, J. (author), Fluri, D. (author), Ecker, G. (author), Zdrazil, B. (author), Terron, A. (author), Jennings, P. (author), van der Burg, B. (author), Dooley, S. (author), Meijer, A.H. (author), Willighagen, E. (author), Martens, M. (author), Evelo, C. (author), Mombelli, E. (author), Taboureau, O. (author), Mantovani, A. (author), Hardy, B. (author), Koch, B. (author), Escher, S. (author), van Thriel, C. (author), Cadenas, C. (author), Kroese, D. (author), van de Water, B. (author), Hengstler, J.G. (author)
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a formalized, transparent and quality-controlled way, mechanistic information to apical endpoints for regulatory purposes. AOP links a molecular initiating event (MIE) to the adverse outcome (AO) via key events (KE), in a way specified by key event...
article 2017
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van Hulst, M. (author), Langenberg, J.P. (author), de Klerk, W.P.C. (author), Alblas, M.J. (author)
The toxicity of smoke-generating ammunition can be established by looking at the complete hand grenade or only at the smoke composition. In this paper both approaches are described. The toxicity of a signalling smoke was assessed as a complete smoke hand grenade whereas for a 76 mm screening smoke canister only a red phosphorus (RP) pellet was...
article 2017
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Deziel, N.C. (author), Nuckols, J.R. (author), Jones, R.R. (author), Graubard, B.I. (author), de Roos, A.J. (author), Pronk, A. (author), Gourley, C. (author), Colt, J.S. (author), Ward, M.H. (author)
Proximity to facilities emitting polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/F) has been associated with increased risk of non-Hodgkin lymphoma (NHL). There is limited information about whether proximity to industrial sources leads to indoor PCDD/F contamination of homes. We measured carpet dust concentrations (pg/g...
article 2017
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Ghosh, M (author), Oner, D. (author), Poels, K. (author), Tabish, A.M. (author), Vlaanderen, J. (author), Pronk, A. (author), Kuijpers, E. (author), Lan, Q. (author), Vermeulen, R. (author), Bekaert, B. (author), Hoet, P.H.M. (author), Godderis, L. (author)
This study was designed to assess the epigenetic alterations in blood cells, induced by occupational exposure to multi-wall carbon nanotubes (MWCNT). The study population comprised of MWCNT-exposed workers (n=24) and unexposed controls (n=43) from the same workplace. We measured global DNA methylation/hydroxymethylation levels on the 5th...
article 2017
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Meuken, D. (author), van Lingen, J.N.J. (author), Polk-LaBonte, A. (author), Domanico, J. (author)
A significant health and possibly environmental problem is associated with military smokes and obscurants. Besides the fact that these obscuration munitions pose a significant toxicity hazard to the user, the environmental impact of these munitions can also be significant (e.g. due to the use of hexachlorethane). The objective of the SERDP...
conference paper 2016
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Woutersen, R.A. (author), Soffers, A.E.M.F. (author), Kroese, E.D. (author), Krul, C.A.M. (author), van der Laan, J.W. (author), van Benthem, J. (author), Luijten, M. (author)
Sub-chronic toxicity studies of 163 non-genotoxic chemicals were evaluated in order to predict the tumour outcome of 24-month rat carcinogenicity studies obtained from the EFSA and ToxRef databases. Hundred eleven of the 148 chemicals that did not induce putative preneoplastic lesions in the sub-chronic study also did not induce tumours in the...
article 2016
Searched for: subject%3A%22Toxicity%22
(1 - 20 of 307)

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