Searched for: subject%3A%22Tissue%255C%2Brepair%22
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Gvaramia, D. (author), Blaauboer, M.E. (author), Hanemaaijer, R. (author), Everts, V. (author)
Fibrosis underlies the pathogenesis of numerous diseases and leads to severe damage of vital body organs and, frequently, to death. Better understanding of the mechanisms resulting in fibrosis is essential for developing appropriate treatment solutions and is therefore of upmost importance. Recent evidence suggests a significant antifibrotic...
article 2013
document
Rubbens, M.P. (author), Mol, A. (author), van Marion, M.H. (author), Hanemaaijer, R. (author), Bank, R.A. (author), Baaijens, F.P.T. (author), Bouten, C.V.C. (author), TNO Kwaliteit van Leven (author)
Similar to native cardiovascular tissues, the mechanical properties of engineered cardiovascular constructs depend on the composition and quality of the extracellular matrix, which is a net result of matrix remodeling processes within the tissue. To improve tissue remodeling, and hence tissue mechanical properties, various mechanical...
article 2009
document
van Noort, J.M. (author), TNO Kwaliteit van Leven (author)
Toll-like receptors (TLRs) that play key roles in inflammation are also widely expressed in the CNS. While they are well known to activate inflammatory responses to microbial products, TLRs fulfill additional roles in the absence of infection. Emerging evidence suggests that several TLRs play a role in CNS development during fetal life and in...
article 2007
document
te Loo, D.M. (author), Bosma, N. (author), van Hinsbergh, V. (author), Span, P. (author), de Waal, R. (author), Clarijs, R. (author), Sweep, C. (author), Monnens, L. (author), van den Heuvel, L. (author), Gaubius Instituut TNO (author)
The pathogenesis of hemolytic uremic syndrome (D+ HUS) is characterized by endothelial damage of glomeruli and tubules within the kidney. In several other diseases in which glomerular endothelial damage occurs, elevated serum levels of vascular endothelial growth factor (VEGF) have been reported. VEGF is involved in angiogenesis,...
article 2004
Searched for: subject%3A%22Tissue%255C%2Brepair%22
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