Searched for: subject%3A%22Threshold%255C%2Bof%255C%2Btoxicological%255C%2Bconcern%22
(1 - 9 of 9)
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Koster, S. (author), Leeman, W.R. (author), Verheij, E.R. (author), Dutman, A.E. (author), van Stee, L.L.P. (author), Munch Nielsen, L. (author), Ronsmans, S. (author), Noteborn, H. (author), Krul, L. (author)
A main challenge in food safety research is to demonstrate that processing of foodstuffs does not lead to the formation of substances for which the safety upon consumption might be questioned. This is especially so since food is a complex matrix in which the analytical detection of substances, and consequent risk assessment thereof, is difficult...
article 2015
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Leeman, W.R. (author), Krul, L. (author), Houben, G.F. (author)
The threshold of toxicological concern (TTC) concept is a risk assessment tool for substances present at low oral exposure and lacking hazard data. In the past, several thresholds were elaborated by Munro et al. (1996) and Kroes et al. (2004). For these TTC thresholds, the Cramer class III threshold is based on a broad spectrum of substances,...
article 2014
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Koster, S. (author), Rennen, M. (author), Leeman, W. (author), Houben, G. (author), Muilwijk, B. (author), van Acker, F. (author), Krul, L. (author)
One of the main challenges in food contact materials research is to prove that the presence of non-intentionally added substances (NIAS) is not a safety issue. Migration extracts may contain many unknown substances present at low concentrations. It is difficult and time-consuming to identify all these potential NIAS and concurrently to assess...
article 2014
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Leeman, W.R. (author), Krul, L. (author), Houben, G.F. (author)
Upon analysis of chemically complex food matrices a forest of peaks is likely to be found. Identification of these peaks and concurrent determination of the toxicological relevance upon exposure is very time consuming, expensive and often requires animal studies. Recently, a safety assessment framework based on the Threshold of Toxicological...
article 2013
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Rennen, M.A.J. (author), Koster, S. (author), Krul, C.A.M. (author), Houben, G.F. (author)
The toxicological assessment of chemically complex food matrices (CCFM) usually is very time consuming, expensive and uses many animal studies. Improvements to obtain a more efficient assessment process remain limited as long as we retain traditional approaches to toxicological risk assessment. New concepts would be needed to achieve real...
article 2011
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Tluczkiewicz, I. (author), Buist, H.E. (author), Martin, M.T. (author), Mangelsdorf, I. (author), Escher, S.E. (author)
The present report describes a strategy to refine the current Cramer classification of the TTC concept using a broad database (DB) termed TTC RepDose. Cramer classes 1-3 overlap to some extent, indicating a need for a better separation of structural classes likely to be toxic, moderately toxic or of low toxicity.Groups of structurally similar...
article 2011
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Koster, S. (author), Boobis, A.R. (author), Cubberley, R. (author), Hollnagel, H.M. (author), Richling, E. (author), Wildemann, T. (author), W├╝rtzen, G. (author), Galli, C.L. (author)
Unknown substances, not previously observed, are frequently detected in foods by quality control laboratories. In many cases, the assessment of these 'new' substances requires additional chemical analysis for their identification prior to assessing risk. This identification procedure can be time-consuming, expensive and in some instances...
article 2011
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Escher, S.E. (author), Tluczkiewicz, I. (author), Batke, M. (author), Bitsch, A. (author), Melber, C. (author), Kroese, E.D. (author), Buist, H.E. (author), Mangelsdorf, I. (author), TNO Kwaliteit van Leven (author)
The thresholds of toxicological concern (TTCs) define limit values for substances of unknown toxicity below which dietary intake is considered to be of no concern to human health. The TTC concept has already been used for risk assessment of e.g. food contaminants or flavoring substances and is in discussion to be applied to other classes of...
article 2010
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Kroes, R. (author), Renwick, A.G. (author), Feron, V. (author), Galli, C.L. (author), Gibney, M. (author), Greim, H. (author), Guy, R.H. (author), Lhuguenot, J.C. (author), van de Sandt, J.J.M. (author), TNO Kwaliteit van Leven (author)
The threshold of toxicological concern (TTC) has been used for the safety assessment of packaging migrants and flavouring agents that occur in food. The approach compares the estimated oral intake with a TTC value derived from chronic oral toxicity data for structurally-related compounds. Application of the TTC approach to cosmetic ingredients...
article 2007
Searched for: subject%3A%22Threshold%255C%2Bof%255C%2Btoxicological%255C%2Bconcern%22
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