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van Dommelen, P. (author), Barios, R.M. (author), Arnaud, L. (author), le Masne, Q. (author), Koledova, E. (author)Worldwide regulations during COVID-19 positively and negatively impacted self-management in paediatric patients with chronic medical conditions. We investigated the impact of regulations on adherence to recombinant human growth hormone (r-hGH) therapy in paediatric patients with growth disorders, using real-world adherence data extracted March...article 2023
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Suchowerska, A.K. (author), Stokman, G. (author), Palmer, J.T. (author), Coghlan, P.A. (author), Pieterman, E.J. (author), Keijzer, N. (author), Lambert, G. (author), Chemello, K. (author), Jaafar, A.K. (author), Parmar, J. (author), Yan, L. (author), Tong, Y. (author), Mu, L. (author), Princen, H.M.G. (author), Bonnar, J. (author), Evison, B.J. (author)Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibits the clearance of low-density lipoprotein (LDL) cholesterol (LDL-C) from plasma by directly binding with the LDL receptor (LDLR) and sending the receptor for lysosomal degradation. As the interaction promotes elevated plasma LDL-C levels, and therefore a predisposition to...article 2022
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The effect of transdermal gender-affirming hormone therapy on markers of inflammation and hemostasisSchutte, M.H. (author), Kleemann, R. (author), Nota, N.M. (author), Wiepjes, C.M. (author), Snabel, J.M. (author), T'Sjoen, G. (author), Thijs, A. (author), den Heijer, M. (author)Background: Cardiovascular risk is increased in transgender persons using gender-affirming hormone therapy. To gain insight into the mechanism by which sex hormones affect cardiovascular risk in transgender persons, we investigated the effect of hormone therapy on markers of inflammation and hemostasis. Methods: In this exploratory study, 48...article 2022
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- Zhang, C. (author), Hu, M. (author), di Maio, F. (author), Sprecher, B. (author), Yang, X. (author), Tukker, A. (author) article 2022
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Tornincasa, V. (author), Dixon, V. (author), Le Masne, Q. (author), Martin, B. (author), Arnaud, L. (author), van Dommelen, P. (author), Koledova, E. (author)Digital health has seen rapid advancements over the last few years in helping patients and their healthcare professionals better manage treatment for a variety of illnesses, including growth hormone (GH) therapy for growth disorders in children and adolescents. For children and adolescents requiring such therapy, as well as for their parents,...article 2022
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Venhorst, J. (author), van der Vossen, J.M.B.M. (author), Agamennone, V. (author)The pathogenic Clostridioides difficile and Clostridium perfringens are responsible for many health care-associated infections as well as systemic and enteric diseases. Therefore, they represent a major health threat to both humans and animals. Concerns regarding increasing antibiotic resistance (related to C. difficile and C. perfringens) have...article 2022
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Assefi, A. (author), van Dommelen, P. (author), Arnaud, L. (author), Otero, C. (author), Fernandez-Luque, L. (author), Koledova, E. (author), Calliari, L.E. (author)Background: Recombinant human growth hormone (rhGH) therapy is an effective treatment for children with growth disorders. However, poor outcomes are often associated with suboptimal adherence to treatment. Objective: The easypod connected injection device records and transmits injection settings and dose data from patients receiving rhGH. In...article 2022
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Burger, F. (author), Neerincx, M.A. (author), Brinkman, W.P. (author)E-mental health for depression is increasingly used in clinical practice, but patient adherence suffers as therapist involvement decreases. One reason may be the low responsiveness of existing programs: especially autonomous systems are lacking in their input interpretation and feedback-giving capabilities. Here, we explore (a) to what extent a...article 2022
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Spataru, A. (author), van Dommelen, P. (author), Arnaud, L. (author), Le Masne, Q. (author), Quarteroni, S. (author), Koledova, E.B. (author)Background: Long-term persistence of use and starting at the earliest possible age are associated with attainment of near-normal adult or final height in children who are treated with growth hormone therapy. However, there are many factors associated with a lack of persistence. Our aim was to study persistence of use in children with growth...article 2021
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Spataru, A. (author), van Dommelen, P. (author), Arnaud, L. (author), Le Masne, Q. (author), Quarteroni, S. (author), Koledova, E.B. (author)Background: Suboptimal adherence to recombinant human growth hormone (r-hGH) treatment can lead to suboptimal clinical outcomes. Being able to identify children who are at risk of suboptimal adherence in the near future, and take adequate measures to support adherence, may maximize clinical outcomes. Our aim was to develop a model based on data...article 2021
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Sandin, K. (author), Gjengedal, R.G.H. (author), Osnes, K. (author), Hannisdal, M. (author), Berge, T. (author), Leversen, J.S.R. (author), Røv, L.G. (author), Lagerveld, S. (author), Blonk, R. (author), Nordahl, H.M. (author), Shields, G. (author)Background: Common mental disorders such as depression and anxiety are major contributors to the global burden of disease. Affected individuals suffer reduced quality of life, impaired functioning and reduced capacity to work. Maintaining employment is an important determinant for health and wellbeing, and the economic impact of depression and...article 2021
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van Veelen, N. (author), Boonekamp, R.C. (author), Schoonderwoerd, T.A.J. (author), van Emmerik, M.L. (author), Nijdam, M.J. (author), Bruinsma, B. (author), Geuze, E. (author), Jones, C. (author), Vermetten, E. (author)With the application of virtual reality (VR), tailored interventions can be created that mirror the traumatic experiences of veterans with post-traumatic stress disorder (PTSD). Visual elements can be mimicked, and auditory and other senses stimulated. In doing so, the degree of immersion can be adjusted to optimize the therapeutic process....article 2021
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Burger, F. (author), Neerincx, M.A. (author), Brinkman, W.P. (author)The cognitive approach to psychotherapy aims to change patients' maladaptive schemas, that is, overly negative views on themselves, the world, or the future. To obtain awareness of these views, they record their thought processes in situations that caused pathogenic emotional responses. The schemas underlying such thought records have, thus far,...article 2021
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Bongers, C.C.W.G. (author), de Korte, J.Q. (author), Catoire, M. (author), Greefhorst, J. (author), Hopman, M.T.E. (author), Kingma, B. (author), Eijsvogels, T.M.H. (author)COVID-19 healthcare personnel (HCP) use personal protective equipment (PPE; ie, isolation gowns, eye protection, facemasks and respirators) to safely perform their medical duties. However, PPE creates a microenvironment around the skin due to a higher thermal resistance and lower water vapour permeability of the materials being used compared...article 2021
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Araujo, M. (author), van Dommelen, P. (author), Koledova, E.B. (author), Srivastava, J. (author)The problem of consistent therapy adherence is a current challenge for health informatics, and its solution can increase the success rate of treatments. Here we show a methodology to predict, at individual-level, future therapy adherence for patients receiving daily injections of growth hormone (GH) therapy for GH deficiency. Our proposed model...article 2021
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Bohnert, S. (author), van den Berg, R.M. (author), Mikler, J. (author), Klaassen, S.D (author), Joosen, M.J.A. (author)Organophosphorus nerve agents (NA) inhibit acetylcholinesterase (AChE) which results in the over-stimulation of both the central and peripheral nervous systems, creating a toxic syndrome that can be lethal if left untreated (Cannard, 2006). It is standard practice to treat Sarin (GB) intoxication with an oxime, an antimuscarinic such as atropine...article 2020
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Wickramasinghe, K. (author), Mathers, J.C. (author), Wopereis, S. (author), Marsman, D.S. (author), Griffiths, J.C. (author)Across the globe, there has been a marked increase in longevity, but significant inequalities remain. These are exacerbated by inadequate access to proper nutrition and health care services and to reliable information to make the decisions related to nutrition and health care. Many in economically developing as well as developed societies are...article 2020
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Pouwer, M.G. (author), Pieterman, E.J. (author), Worms, N. (author), Keijzer, N. (author), Jukema, J.W. (author), Gromada, J. (author), Gusarova, V. (author), Princen, H.M.G. (author)Atherosclerosis-related cardiovascular disease causes nearly 20 million deaths annually. Most patients are treated after plaques develop, so therapies must regress existing lesions. Current therapies reduce plaque volume, but targeting all apoB-containing lipoproteins with intensive combinations that include alirocumab or evinacumab-monoclonal...article 2020
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Gjengedal, R.G.H. (author), Reme, S.E. (author), Osnes, K. (author), Lagerveld, S. (author), Blonk, R.W.B. (author), Sandin, K. (author), Berge, T. (author), Hjemdal, O. (author)BACKGROUND: Common mental disorders (CMD) are leading causes of sickness absence. Treatments for CMD that both reduce symptoms and support work participation urgently need to be developed. OBJECTIVE: Determine the potential effects of work-focused therapy combining work interventions with either meta cognitive therapy or cognitive behavioural...article 2020
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Bal, M. (author), Benders, J. (author), Dhondt, S. (author), Vermeerbergen, L. (author)Despite the emergence of head-worn displays at work around forty years ago, few studies have appeared about their impact on job content. To investigate this, a systematic literature review was conducted on these devices and job content, defined as job demands and controls. In total, 3481 studies were identified using five scientific databases....article 2020