Experiences of a High-Risk Population with Prenatal Hemoglobinopathy Carrier Screening in a Primary Care Setting: a Qualitative Study

Carrier screening for hemoglobinopathies (HbPs; sickle cell disease and thalassemia) aims to facilitate autonomous reproductive decision-making. In the absence of a Dutch national HbP carrier screening program, some primary care midwives offer screening on an ad hoc basis. This qualitative descriptive study explores how pregnant women perceive...

Variation by ethnicity in incidence of diabetes type 1 and clinical condition at onset in the Netherlands

Effects of iron salts and haemosiderin from a thalassaemia patient on oxygen radical damage as measured in the comet assay

Thalassaemia is a group of genetic diseases where haemoglobin synthesis is impaired. This chronic anaemia leads to increased dietary iron absorption, which develops into iron overload pathology. Treatment through regular transfusions increases oxygen capacity but also provides iron through the red cells' haemoglobin. An essential treatment, in...

Kwaliteit van leven bij kinderen met sikkelcelziekte in de regio Amsterdam [Quality of life of children with sickle cell disease in the Amsterdam area]

Objective. To determine the differences in quality of life between children with sickle cell disease and healthy immigrant children. Design. Descriptive, comparative. Method. The quality of life of children with sickle cell disease between 5 and 15 years old being treated in the Emma Children's Hospital AMC in Amsterdam, the Netherlands, was...