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Komninos, D. (author), Ramos, L. (author), van der Heijden, G.W. (author), Morrison, M.C. (author), Kleemann, R. (author), van Herwaarden, A.E. (author), Kiliaan, A.J. (author), Arnoldussen, I.A.C. (author)Obesity can disturb spermatogenesis and subsequently affect male fertility and reproduction. In our study, we aim to elucidate at which cellular level of adult spermatogenesis the detrimental effects of obesity manifest. We induced high fat diet (HFD) obesity in low-density lipoprotein receptor knock-out Leiden (Ldlr−/−.Leiden) mice, and studied...article 2022
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Joustra, S.D. (author), van der Plas, E.M. (author), Goede, J. (author), Oostdijk, W. (author), Delemarre-van de Waal, H.A. (author), Hack, W.W.M. (author), van Buuren, S. (author), Wit, J.M. (author)Aim Accurate calculations of testicular volume standard deviation (SD) scores are not currently available. We constructed LMS-smoothed age-reference charts for testicular volume in healthy boys. Methods The LMS method was used to calculate reference data, based on testicular volumes from ultrasonography and Prader orchidometer of 769 healthy...article 2015
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Wiersma, T. (author), Kamphuis, M. (author), van den Akker-van Marle, E. (author)Undescended testis (UDT), congenital or acquired, is the most common genital anomaly seen in boys. It can be treated surgically by orchiopexy, but there is no agreement about the age at which the operation should be performed. Using available information, an expert group assessed the outcomes of orchiopexy at different ages, expressed in quality...article 2014
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Wijnands, M. (author)Multiple epidermoid cysts were observed microscopically in the testis of a New Zealand White rabbit. The cysts were lined by stratified squamous keratinizing epithelium and filled with concentric layers of keratin. Testicular epidermoid cysts have been described in men but are very rare in animals. © 2011 Elsevier GmbH.article 2012
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- van den Akker-van Marle, M.E. (author), van Gameren-Oosterom, H.B.M. (author), Kamphuis, M. (author), Pierik, F.H. (author), Pierik, F. (author) book 2012
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Kamphuis, M. (author), Pierik, F.H. (author), van Gameren-Oosterom, H.B.M. (author), van den Akker-van Marle, M.E. (author)De JGZ speelt een belangrijke rol bij een goede signalering, registratie en diagnostiek bij niet-scrotale testis (NST). Waar nodig wordt verwezen naar de kinderchirurg/-uroloog voor nader onderzoek en eventuele operatieve behandeling.book 2012
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Tonk, E.C.M. (author), de Groot, D.M.G. (author), Penninks, A.H. (author), Waalkens - Berendsen, I.D.H. (author), Wolterbeek, A.P.M. (author), Slob, W. (author), Piersma, A.H. (author), van Loveren, H. (author), TNO Kwaliteit van Leven (author)Current developmental and reproductive toxicity protocols include only a limited set of parameters for effects on the developing immune system. In this study, a wide range of immunological parameters were included in a pre- and postnatal developmental toxicity study. Dose-response data were compared to determine the relative sensitivity of...article 2010
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Janssen, G.B. (author), Penninks, A.H. (author), Knippels, L.M.J. (author), van Zijverden, M. (author), Spanhaak, S. (author), TNO Kwaliteit van Leven (author)This paper describes studies performed with ERA-63 a low molecular weight pharmaceutical with intended immunomodulatory effects. Since this compound was also known to have estrogenic activity a non-conventional approach was taken in order to differentiate between estrogenic and non-estrogenic-induced immunomodulatory effects. EE was included not...article 2008
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- Hack, W.M. (author), Goede, J. (author), Pierik, F.H. (author), Sijstermans, K. (author), TNO Bouw en Ondergrond (author) article 2008
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Hack, W.W.M. (author), Sijstermans, K. (author), van der Voort-Doedens, L.M. (author), Meijer, R.W. (author), Heij, H.A. (author), Delemarre-van de Waal, H.A. (author), Pierik, F.H. (author), TNO Kwaliteit van Leven (author)Undescended testis (UDT) is one of the most common urogenital abnormalities in boys. UDT is defined as a testis which cannot be brought into a stable scrotal position. At present, congenital and acquired forms of UDT are recognised. Congenital UDT is defined as a UDT which has never descended from birth. Acquired UDT is defined as a UDT which...article 2008
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Goede, J. (author), Pierik, F.H. (author), Hack, W.W.M. (author), Algra, P.R. (author), TNO Bouw en Ondergrond (author)In three boys aged 15, 9, and 10 years respectively scrotal ultrasound revealed testicular microlithiasis (TM). Two boys were free of symptoms and one suffered from testicular pain. TM is characterized by multiple echogenic foci within the seminiferous tubules with no acoustic shadowing. The pathophysiology is largely unknown. In adult men, TM...article 2008
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Hack, W.W.M. (author), Voort van der-Doedens, L.M. (author), Sijstermans, K. (author), Meijer, R.W. (author), Pierik, F.H. (author), TNO Kwaliteit van Leven (author)Background: Since the mid-1990s, acquired undescended testis has gradually been recognised as a separate entity for which the efficacy of prepubertal surgery has not been univocally been demonstrated. Therefore, in our hospital, orchidopexy was no longer routinely performed for acquired undescended testis. Aim: To investigate the effect of...article 2007
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Lina, B.A.R. (author), Bär, A. (author), TNO Voeding (author)The toxicity of α-cyclodextrin (α-CD), a cyclic polymer of six α-1,4-linked glucopyranosyl units with potential applications as a food ingredient, more specifically a water-soluble dietary fiber, was examined in a 4-week range finding study and a 13-week oral toxicity study in rats. In the 4-week study, the test substance was administered to...article 2004
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Aendekerk, R.P.P. (author), van Leerdam, F.J.M. (author), Hirasing, R.A. (author)For non-scrotal testes a distinction can be made between retractile testes (completely descended and normally developed but sometimes situated subcutaneously in the groin area), retained testes (testes cannot be brought into the scrotum or this can only be achieved using light manual pressure) and ectopic testes (lying outside of the descent...article 2002
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Anderson, D. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO BIBRA (author)Butadiene (BD) and its 2-methyl analogue, isoprene, have been extensively studied in animals and BD in population studies. Both chemicals are metabolised by liver cytochrome P450 dependent monogenases to monoepoxide and diepoxide intermediates. The diepoxide intermediates of both compounds were mutagenic in Salmonella typhimurium. However,...article 2001
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Meijer, C. (author), Timmer, A. (author), de Vries, E.G.E. (author), Groten, J.P. (author), Knol, A. (author), Zwart, N. (author), Dam, W.A. (author), Sleijfer, D.Th. (author), Mulder, N.H. (author)Cisplatin (CDDP) is an extremely active drug in the treatment of germ- cell tumours. Earlier, we found an unexpected inverse correlation between the total amount of sulfhydryl groups and CDDP sensitivity in a panel of 3 human germ-cell tumour and 3 colon-carcinoma cell lines. Major components of the sulfhydryl groups are glutathione and...article 2000
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Welters, M.J.P. (author), Braakhuis, B.J.M. (author), Jacobs-Bergmans, A.J. (author), Kegel, A. (author), Baan, R.A. (author), van der Vijgh, W.J.F. (author), Fichtinger-Schepman, A.M.J. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)Background: Response to cisplatin-therapy is assumed to be related to the formation of platinum (Pt)-DNA adducts. Measurement of these adducts prior to therapy could be of value to improve cisplatin based cancer therapy. Materials and methods: We determined Pt-GG and Pt-AG adduct levels by use of 32P-postlabeling after ex vivo cisplatin...article 1999
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Gimeno, S. (author), Komen, H. (author), Jobling, S. (author), Sumpter, J. (author), Bowmer, T. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Sexually mature male common carp (Cyprinus carpio) were exposed for a 3-month period to sublethal concentrations of 4-tert-pentylphenol (TPP) and to 17β-estradiol (E2) during spermatogenesis. This was part of a broad research programme investigating the effects of TPP on the life stages of the carp which might prove susceptible to endocrine...article 1998
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Visser, C.J.T. (author), van Garderen-Hoetmer, A. (author), Klijn, J.G.M. (author), Foekens, J.A. (author), Woutersen, R.A. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)In a previous short-term study (4 months) we found that Sandostatin, when administered prophylactically, inhibited growth of putative pre-neoplastic ductular lesions induced in hamster pancreas by N-nitrosobis(2-oxopropyl)amine (BOP), but not of acinar lesions induced in rat pancreas by azaserine. The present long-term (12 months) study was...article 1996
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Hack, W.W.M. (author), Hirasing, R.A. (author), TNO Preventie en Gezondheid (author)Objective. To differentiate undescended testis into a congenital and an acquired form using earlier information on testis position. Design. Descriptive. Setting. Paediatric outpatients' clinic, Medical Centre Alkmaar, the Netherlands. Method. In a 3-year period (1991-1994), 77 boys were referred to the paediatric outpatients' clinic for non...article 1996
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