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Notenboom, S. (author), Weigand, K.M. (author), Proost, J.H. (author), van Lipzig, M.M.H. (author), van de Steeg, E. (author), van den Broek, P.H.H. (author), Greupink, R. (author), Russel, F.G.M. (author), Groothuis, G.M.M. (author)Drug-induced liver injury (DILI) is a common reason for drug withdrawal from the market. An important cause of DILI is drug-induced cholestasis. One of the major players involved in drug-induced cholestasis is the bile salt efflux pump (BSEP; ABCB11). Inhibition of BSEP by drugs potentially leads to cholestasis due to increased (toxic)...article 2018
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Bothe, M.K. (author), Maathuis, A.J.H. (author), Bellmann, S. (author), van der Vossen, J.M.B.M. (author), Berressem, D. (author), Koehler, A. (author), Schwejda-Guettes, S. (author), Gaigg, B. (author), Kuchinka-Koch, A. (author), Stover, J.F. (author)Lactulose, a disaccharide of galactose and fructose, used as a laxative or ammonia-lowering drug and as a functional food ingredient, enhances growth of Bifidobacterium and Lactobacillus at clinically relevant dosages. The prebiotic effect of subclinical dosages of Lactulose, however, remains to be elucidated. This study analyses changes in the...article 2017
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Pantophlet, A.J. (author), Wopereis, S. (author), Eelderink, C. (author), Vonk, R.J. (author), Stroeve, J.H. (author), Bijlsma, S. (author), van Stee, L. (author), Bobeldijk, I. (author), Priebe, M.G. (author)Background: The consumption of products rich in cereal fiber and with a low glycemic index is implicated in a lower risk of metabolic diseases. Previously, we showed that the consumption of fiber-rich pasta compared with bread resulted in a lower rate of appearance of exogenous glucose and a lower glucose clearance rate quantified with a dual...article 2017
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Vlaming, M.L. (author), van Duijn, E. (author), Dillingh, M.R. (author), Brands, R. (author), Windhorst, A.D. (author), Hendrikse, N.H. (author), Bosgra, S. (author), Burggraaf, J. (author), de Koning, M.C. (author), Fidder, A. (author), Mocking, J.A. (author), Sandman, H. (author), de Ligt, R.A. (author), Fabriek, B.O. (author), Pasman, W.J. (author), Seinen, W. (author), Alves, T. (author), Carrondo, M. (author), Peixoto, C. (author), Peeters, P.A. (author), Vaes, W.H. (author)Preclinical development of new biological entities (NBEs), such as human protein therapeutics, requires considerable expenditure of time and costs. Poor prediction of pharmacokinetics in humans further reduces net efficiency. In this study, we show for the first time that pharmacokinetic data of NBEs in humans can be successfully obtained early...article 2015
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Reus, A.A. (author), Maas, W.J.M. (author), Jansen, H.T. (author), Constant, S. (author), Staal, Y.C.M. (author), van Triel, J.J. (author), Kuper, C.F. (author)The respiratory route is an important portal for human exposure to a large variety of substances. Consequently, there is an urgent need for realistic in vitro strategies for evaluation of the absorption of airborne substances with regard to safety and efficacy assessment. The present study investigated feasibility of a 3D human airway epithelial...article 2014
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- Prinsen, M.K. (author) doctoral thesis 2014
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- Louisse, J. (author), Bosgra, S. (author), Blaauboer, B.J. (author), Rietjens, Y.M.C.M. (author), Verwei, M. (author) article 2014
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Solecki, R. (author), Barbellion, S. (author), Bergmann, B. (author), Bürgin, H. (author), Buschmann, J. (author), Clark, R. (author), Comotto, L. (author), Fuchs, A. (author), Faqi, A.S. (author), Gerspach, R. (author), Grote, K. (author), Hakansson, H. (author), Heinrich, V. (author), Heinrich-Hirsch, B. (author), Hofmann, T. (author), Hübel, U. (author), Inazaki, T.H. (author), Khalil, S. (author), Knudsen, T.B. (author), Kudicke, S. (author), Lingk, W. (author), Makris, S. (author), Müller, S. (author), Paumgartten, F. (author), Pfeil, R. (author), Rama, E.M. (author), Schneider, S. (author), Shiota, K. (author), Tamborini, E. (author), Tegelenbosch, M. (author), Ulbrich, B. (author), van Duijnhoven, E.A.J. (author), Wise, D. (author), Chahoud, I. (author)This article summarizes the 7th Workshop on the Terminology in Developmental Toxicology held in Berlin, May 4-6, 2011. The series of Berlin Workshops has been mainly concerned with the harmonization of terminology and classification of fetal anomalies in developmental toxicity studies. The main topics of the 7th Workshop were knowledge on the...article 2013
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Lilliu, G. (author), Meda, A. (author)Fire analysis of precast segmental tunnels involves several problems, mainly related to the soil-structure interaction during fire exposure, coupled with material degradation. Temperature increase in the tunnel is the cause of thermal expansion of the lining, which is resisted by the soil pressure. Furthermore, the increase of temperature in the...article 2013
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Jacobs, P.L. (author), Ridder, L. (author), Ruijken, M. (author), Rosing, H. (author), Jager, N.G.L. (author), Beijnen, J.H. (author), Bas, R.R. (author), van Dongen, W.D. (author), TNO Triskelion BV (author)Background: Comprehensive identification of human drug metabolites in first-in-man studies is crucial to avoid delays in later stages of drug development. We developed an efficient workflow for systematic identification of human metabolites in plasma or serum that combines metabolite prediction, high-resolution accurate mass LC-MS and MS vendor...article 2013
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Krishnan, S. (author), Verheij, E.E.R. (author), Bas, R.C. (author), Hendriks, M.W.B. (author), Hankemeier, T. (author), Thissen, U. (author), Coulier, L. (author)RATIONALE Mass spectra obtained by deconvolution of liquid chromatography/high-resolution mass spectrometry (LC/HRMS) data can be impaired by non-informative mass-over-charge (m/z) channels. This impairment of mass spectra can have significant negative influence on further post-processing, like quantification and identification. METHODS A metric...article 2013
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Buist, H. (author), Aldenberg, T. (author), Batke, M. (author), Escher, S. (author), Kühne, R. (author), Marquart, H. (author), Pauné, E. (author), Rorije, E. (author), Schüürmann, G. (author), Kroese, D.E. (author)Risk assessment of chemicals usually implies data evaluation of in vivo tests in rodents to conclude on 31 their hazards. The FP7 European project OSIRIS has developed integrated testing strategies (ITS) for rel- 32 evant toxicological endpoints to avoid unnecessary animal testing and thus to reduce time and costs. This 33 paper describes the...article 2013
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Tonk, E.C.M. (author), de Groot, D.M.G. (author), Wolterbeek, A.P.M. (author), Penninks, A.H. (author), Waalkens-Berendsen, I.D.H. (author), Piersma, A.H. (author), van Loveren, H. (author)The susceptibility of developing immune system to chemical disruption warrants the assessment of immune parameters in reproductive and developmental testing protocols. In this study, a wide range of immune endpoints was included in an extended one-generation reproduction toxicity study (EOGRTS) design to determine the relative sensitivity of...article 2013
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Coulier, L. (author), Muilwijk, B. (author), Bijlsma, S. (author), Noga, M. (author), Tienstra, M. (author), Attali, A. (author), van Aken, H. (author), Suidgeest, E. (author), Tuinstra, T. (author), Luider, T.M. (author), Hankemeier, T. (author), Bobeldijk, I. (author)Analysis of metabolites in biofluids by gas chromatography-mass spectrometry (GC-MS) after oximation and silylation is a key method in metabolomics. The GC-MS method was modified by a modified vial design and sample work-up procedure in order to make the method applicable to small volumes of cerebrospinal fluid (CSF), i. e. 10 μL, with similar...article 2013
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Kleinnijenhuis, A.J. (author), Staal, Y.C.M. (author), Duistermaat, E. (author), Engel, R. (author), Woutersen, R.A. (author)Formaldehyde (FA) is suspected of being associated with the development of leukemia. An inhalation experiment with FA was performed in rats to study whether FA can enter the blood and could thus cause systemic toxicity in remote tissues such as the bone marrow. Therefore, a sophisticated analytical method was developed to detect blood...article 2013
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Radonjic, M. (author), Cappaert, N.L.M. (author), de Vries, E.F.J. (author), de Esch, C.E.F. (author), Kuper, F.C. (author), van Waarde, A. (author), Dierckx, R.A.J.O. (author), Wadman, W.J. (author), Wolterbeek, A.P.M. (author), Stierum, R.H. (author), de Groot, D.M.G. (author)Maternal exposure to the neurotoxin methylmercury (MeHg) has been shown to have adverse effects on neural development of the offspring in man. Little is known about the underlying mechanisms by which MeHg affects the developing brain. To explore the neurodevelopmental defects and the underlying mechanism associated with MeHg exposure, the...article 2013
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van Mierlo, G.J.D. (author), Cnubben, N.H.P. (author), Kuper, C.F. (author), Wolthoorn, J. (author), van Meeteren-Kreikamp, A.P. (author), Nagtegaal, M.M. (author), Doornbos, R. (author), Ganderup, N.-C. (author), Penninks, A.H. (author)The use of recombinant human proteins for the treatment of several diseases has increased considerably during the last decades. A major safety and efficacy issue of biopharmaceuticals is their potential immunogenicity. To prevent immunogenicity, biotechnology-derived proteins are engineered to be as human-like as possible. Immunogenicity is...article 2013
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van den Akker-van Marle, M.E. (author), Kamphuis, M. (author), van Gameren-Oosterom, H.B.M. (author), Pierik, F.H. (author), Kievit, J. (author)Background. Undescended testis (UDT) or cryptorchidism is the most common genital anomaly seen in boys and can be treated surgically by orchidopexy. The age at which orchidopexy should be performed is controversial for both congenital and acquired UDT. Methods. A decision analysis is performed in which all available knowledge is combined to...article 2013
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van den Broek, I. (author), Niessen, W.M.A. (author), van Dongen, W.D. (author)Biotechnology increasingly delivers highly promising protein-based biopharmaceutical candidates to the drug development funnel. For successful biopharmaceutical drug development, reliable bioanalytical methods enabling quantification of drugs in biological fluids (plasma, urine, tissue, etc.) are required to generate toxicokinetic (TK),...article 2013
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- Sauerborn, M. (author) article 2013