Searched for: subject%3A%22Synaptic%255C%2Btransmission%22
(1 - 4 of 4)
document
van Helden, H.P.M. (author), van der Wiel, H.J. (author), Zijlstra, J.J. (author), Melchers, B.P.C. (author), Busker, R.W. (author)
The oximes HI-6, HLo-7, HGG-12, HGG-42 and obidoxime were used in a previously developed rat model to evaluate the therapeutic effects of oximes other than acetylcholinesterase (AChE) reactivation (so-called 'nonreactivating effects'). To test this anaesthetized, atropinized and artificially ventilated rats (n = 8 or 16) were poisoned with a...
article 1994
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van Helden, H.P.M. (author), de Lange, J. (author), Busker, R.W. (author), Melchers, B.P.C. (author), Medisch Biologisch Laboratorium TNO (author)
Isolated rat diaphragm preparations treated with soman or with the irreversible and oxime resistant cholinesterase (ChE) inhibitor S27 (see Compounds) showed a considerable recovery of neuromuscular transmission (NMT) during incubation with the (bis)pyridinium oximes HI-6, HGG-12, P2S and obidoxime. In the soman-treated preparations this NMT...
article 1991
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Wolthuis, O. (author), Vanwersch, R.A.P. (author), van der Wiel, H.J. (author), Medisch Biologisch Laboratorium TNO (author)
Previous results had shown that bis-pyridinium oximes, particularly HI-6 are quite effective therapeutically in soman-poisoned rats and mice in vivo and in the rat diaphragm preparation in vitro. The aim of the present study was to investigate the efficacy of bis-pyridinium oximes on soman-inhibited neuromuscular transmission in muscle...
article 1981
document
Vos, J.J. (author), Walraven, P.L. (author), Instituut voor Zintuigfysiologie TNO (author)
On the basis of the concepts, discussed in Part I of this study, a line element is developed to describe colour discrimination data. First the simple case of unsaturated neural data transmission is treated. Then complicating effects of saturation and supersaturation are introduced. The goodness of fit with shapes and orientation of JND-ellipses...
article 1972
Searched for: subject%3A%22Synaptic%255C%2Btransmission%22
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