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Blink, M. (author), Buitenkamp, T.D. (author), van Wouwe, J.P. (author), van Wering, E.R. (author), van der Velden, V.H.J. (author), Zwaan, C.M. (author), TNO Kwaliteit van Leven (author)Children with Down syndrome (DS) have an increased risk for developing both acute myeloid as well as acute lymphoblastic leukemia. These leukemias differ in clinical characteristics and biology compared to leukemias in non-DS children. Moreover, children with DS have an increased risk of side-effects from cytostatic therapy, which complicates...article 2009
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- Pereira, R.R. (author), Draaisma, J.M.T. (author), TNO Kwaliteit van Leven (author) article 2009
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Schmitt, M.A. (author), van Meeteren, N.L. (author), de Wijer, A. (author), van Genderen, F.R. (author), van Graaf, Y.D. (author), Helders, P.J. (author), TNO Kwaliteit van Leven (author)Schmitt MA, van Meeteren NL, de Wijer A, van Genderen FR, van der Graaf Y, Helders PJ: Patients with chronic whiplash-associated disorders: Relationship between clinical and psychological factors and functional health status. Am J Phys Med Rehabil 2009;88:231-238. Objectives: To examine the relative contribution of cervical impairments and...article 2009
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Brenninkmeijer, V. (author), Houtman, I. (author), Blonk, R. (author), TNO Kwaliteit van Leven (author)Background: The World Health Organization considers depression a major health problem and a leading cause of disability. Aim To identify factors which may help to reduce depressive symptoms in a sample of employees sick listed due to mental health problems. Methods: Longitudinal cohort study of employees sick listed for 12-20 weeks due to mental...article 2008
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Meulenbelt, I. (author), Kloppenburg, M. (author), Kroon, H.M. (author), Houwing-Duistermaat, J.J. (author), Garnero, P. (author), Hellio-Le Graverand, M.-P. (author), de Groot, J. (author), Slagboom, P.E. (author), TNO Kwaliteit van Leven (author)Objective: To assess the relationship of biochemical markers and radiographic signs of osteoarthritis (ROA) in the subjects with symptomatic osteoarthritis (OA) at multiple sites of the Genetics osteoARthritis and Progression (GARP) study. Methods: We have measured eight biochemical markers, representing tissue turnover of cartilage, bone,...article 2007
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Reijneveld, S.A. (author), Spijker, J. (author), Dijkshoorn, H. (author), TNO Kwaliteit van Leven (author)Background and Objective: We examined the reliability and validity of self-reported limitations encountered in the activities of daily living (ADL) as measure of functional performance, for Turkish, Moroccan, and indigenous Dutch elderly in the Netherlands. Methods: We obtained data on self-reported ADL measured by Katz' ADL index and on five...article 2007
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van den Heuvel, S.G. (author), van der Beek, A.J. (author), Blatter, B.M. (author), Bongers, P.M. (author), TNO Kwaliteit van Leven (author)Few studies have examined the concepts of workstyle and overcommitment in relation to the occurrence of neck and upper limb symptoms. The aim of this study was to examine whether a high-risk workstyle is a mediator in the relation of work-related exposure (job demands and computer work) and overcommitment to neck and upper limb symptoms. The...article 2007
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Griffith, L.E. (author), Hogg-Johnson, S. (author), Cole, D.C. (author), Krause, N. (author), Hayden, J. (author), Burdorf, A. (author), Leclerc, A. (author), Coggon, D. (author), Bongers, P. (author), Walter, S.D. (author), Shannon, H.S. (author), TNO Kwaliteit van Leven (author)Objective: To determine which literature-based definitions of low back pain (LBP) could be combined to produce sufficiently similar sets for use in a meta-analysis. Study Design and Setting: A group of six international experts participated in an e-mail-administered Delphi process. Literature-based LBP definitions were preliminarily classified...article 2007
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Breuning-Boers, J.M. (author), van Dommelen, P. (author), van Wouwe, J.P. (author), Verkerk, P.H. (author)Objective. To determine the relationship between serum sodium concentration and weight loss as well as residual symptoms in newborns with hypernatremic dehydration caused by insufficient breastfeeding; and to determine the sensitivity of the following rule of thumb 'if weight loss is less than 10%, the baby does not have hypernatremic...article 2006
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Arts, J.H.E. (author), Rennen, M.A.J. (author), de Heer, C. (author), TNO Kwaliteit van Leven (author)Objectives: The critical health effects of formaldehyde exposure include sensory irritation and the potential to induce tumours in the upper respiratory tract. In literature, a concentration as low as 0.24 ppm has been reported to be irritating to the respiratory tract in humans. Nasal tumour-inducing levels in experimental animals seem to be 1...article 2006
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TNO Kwaliteit van Leven (author), IJmker, S. (author), Blatter, B.M. (author), van der Beek, A.J. (author), van Mechelen, W. (author), Bongers, P.M. (author)Background: This article describes the background and study design of the PROMO study (Prospective Research on Musculoskeletal disorders in Office workers). Few longitudinal studies have been performed to investigate the risk factors responsible for the incidence of hand, arm, shoulder and neck symptoms among office workers, given the...article 2006
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Bos, J.E. (author), MacKinnon, S.N. (author), Patterson, A. (author), TNO Defensie en Veiligheid (author)Vehicle motion characteristics differ between air, road, and sea environments, both vestibularly and visually. Effects of vision on motion sickness have been studied before, though less systematically in a naval setting. It is hypothesized that appropriate visual information on self-motion is beneficial in a naval setting and that task...article 2005
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TNO Kwaliteit van Leven (author), Vrijlandt, E.J.L.E. (author), Gerritsen, J. (author), Boezen, H.M. (author), Duiverman, E.J. (author), Hille, E.T.M. (author), de Groot, C.H. (author), Kloosterboer-Boerrigter, H. (author), den Ouden, A.L. (author), Rijpstra, A. (author), Verloove-Vanhorick, S.P. (author), Vogelaar, J.A. (author), Kok, J.H. (author), Ilsen, A. (author), van der Lans, M. (author), van der Boelen - Loo, W.J.C. (author), Lundqvist, T. (author), Heymans, H.S.A. (author), Geven, W.B. (author), Duiverman, M.L. (author), Geven, L.I. (author), Mulder, A.L.M. (author), Gerver, A. (author), Kollée, L.A.A. (author), Reijmers, L. (author), Sonnemans, R. (author), Wit, J.M. (author), Dekker, F.W. (author), Finken, M.J.J. (author), Weisglas-Kuperus, N. (author), Keijzer-Veen, M.G. (author), van der Heijden, A.J. (author), van Goudoever, J.B. (author), van Weissenbruch, M.M. (author), Cranendonk, A. (author), van de Delemarre - Waal, H.A. (author), de Groot, L. (author), Samsom, J.F. (author), de Vries, L.S. (author), Rademaker, K.J. (author), Moerman, E. (author), Voogsgeerd, M. (author), de Kleine, M.J.K. (author), Andriessen, P. (author), van Dielissen - Helvoirt, C.C.M. (author), Mohamed, I. (author), van Straaten, H.L.M. (author), Baerts, W. (author), Veneklaas Slots-Kloosterboer, G.W. (author), Tuller-Pikkemaat, E.M.J. (author), Ens-Dokkum, M.H. (author), van Steenbrugge, G.J. (author)Objective: To study the prevalence of respiratory and atopic symptoms in (young) adults born prematurely, differences between those who did and did not develop Bronchopulmonary Disease (BPD) at neonatal age and differences in respiratory health between males and females. Methods: Design: Prospective cohort study. Setting: Nation wide follow-up...article 2005
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TNO Kwaliteit van Leven (author), Luijsterburg, P.A.J. (author), Bongers, P.M. (author), de Vroome, E.M.M. (author)Objectives: The aim of this study was to investigate the effect of raised bricklaying on physical workload, reported musculoskeletal disorders, sickness absence, and job satisfaction. Methods: A controlled intervention study with a follow-up period of 10 months was performed among 202 bricklayers from 25 construction companies. Results: The...article 2005
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Dekkers, J.C. (author), Geenen, R. (author), Godaert, G.L.R. (author), Bijlsma, J.W.J. (author), van Doornen, L.J.P. (author), TNO Arbeid (author)Objective. To investigate sympathetic (SNS) and parasympathetic (PNS) nervous system activity in patients with recently diagnosed rheumatoid arthritis (RA), and to analyze the association between activity of these systems and disease activity, and complaints that frequently occur in RA, viz., pain, fatigue, negative mood, and stiffness. Methods....article 2004
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Fekkes, M. (author), Pijpers, F.I.M. (author), Verloove-Vanhorick, S.P. (author), TNO Preventie en Gezondheid (author)Objectives: To assess the association between bullying behavior and a wide variety of psychosomatic health complaints and depression. Study design: In a cross-sectional study, 2766 elementary school children age 9 to 12 years filled out a questionnaire on bullying behavior and health complaints. Three groups - bullied children, active bullies,...article 2004
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Bajgar, J. (author), Ševelová, L. (author), Krejčová, G. (author), Fusek, J. (author), Vachek, J. (author), Kassa, J. (author), Herink, J. (author), de Jong, L.P.A. (author), Benschop, H.P. (author)Soman belongs to the most dangerous nerve agents because of the low effectiveness of the presently available antidotes. Soman acts by inhibiting acetylcholinesterase (AChE) both peripherally and centrally, with a subsequent accumulation of neuromediator acetylcholine and other metabolic changes. From the data published in literature it can be...article 2004
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van Wouwe, J.P. (author), Mattiazzo, G.F. (author), El Mokadem, N. (author), Reeser, H.M. (author), Hirasing, R.A. (author)Objective. To determine the incidence and characteristics of type-1 diabetes mellitus (DM) in children aged 0-14 years during the period 1996-1999 and to compare this with previous measurements of the incidence. Design. Descriptive. Method. Data were collected via reports from all practicing paediatricians to the Dutch Paediatric Surveillance...article 2004
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van Helden, H.P.M. (author), Kuijpers, W.C. (author), Diemel, R.V. (author)The purpose of the present study was to investigate: (1) the acute effects of sulfur mustard on airway, lung, and surface tension of bronchoalveolar lavage fluid (BALfluid) in guinea pigs following intratracheal (i.t.) exposure to 1LD50 of an aerosolized solution of sulfur mustard in saline, and (2) the therapeutic efficacy of i.t....article 2004
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Wensing, M. (author), Knulst, A.C. (author), Piersma, S. (author), O'Kane, F. (author), Knol, E.F. (author), Koppelman, S.J. (author)Background: Serologic cross-reactivity among legumes has been described; however, it is rarely clinically significant. In this study 3 patients with a history of anaphylaxis to pea are described who subsequently had symptoms after ingestion of peanut. Objective: We investigated whether the peanut-related symptoms were due to cross-reactivity...article 2003
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