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Veerman, H.E.T. (author), Schleijpen, H.M.A. (author), Brettschneider, S.A. (author), Amram, R. (author)The observable infrared signature of naval platforms is crucial in determining survivability and is therefore an important issue in warfare. Increased detectability in the EM spectrum leads to higher susceptibility against threats like sea skimming anti-ship missiles. The infrared platform signature is not a fixed quantity but a highly dynamic...conference paper 2020
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Zheng, G. (author), Samkharadze, N. (author), Noordam, M.L. (author), Kalhor, N. (author), Brousse, D. (author), Sammak, A. (author), Scappucci, G. (author), Vandersypen, L.M.K. (author)Silicon spin qubits are one of the leading platforms for quantum computation1,2. As with any qubit implementation, a crucial requirement is the ability to measure individual quantum states rapidly and with high fidelity. Since the signal from a single electron spin is minute, the different spin states are converted to different charge states3,4....article 2019
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Vijn, A.R.P.J. (author), Lepelaars, E.S.A.M. (author), Dubbeldam, J. (author), van Gijzen, M. (author), Heemink, A. (author)This paper presents a parameter estimation method to determine the linear behavior of an object constructed of thin plates. Based on the magnetostatic field equations, an integral equation is derived that fully determines the induced magnetization, whenever the spatial magnetic susceptibility distribution is known. This forward problem is used...article 2019
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Pot, M. (author), van Keulen, H. (author), Paulussen, T. (author), Otten, W. (author), van Steenbergen, J. (author), Ruiter, R. (author)Background: In order to promote HPV-vaccination acceptability among mothers of invited girls, we developed a web-based, tailored intervention. This study reports on an experimental pretest for the component of this intervention targeting mothers’ perceptions of their daughters’ susceptibility towards HPV-related risk factors. Statistical versus...article 2019
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- Sileno, G. (author), Boer, A. (author), van Engers, T. (author) conference paper 2019
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Janssen, J.A.A.J. (author), Hasenpflug, H. (author), Janssen, M. (author)Crews of naval vessels lack an up-to-date awareness of those aspects of a ship’s susceptibility to threats that are related to the actual ship signatures (acoustic, magnetic, infrared, etc.). The ship’s susceptibility depends among others on the current configuration of the ship, the environment, the enemy sensor capabilities and the related...conference paper 2018
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Reijnen, A. (author), Geuze, E. (author), Eekhout, I. (author), Maihofer, A.X. (author), Nievergelt, C.M. (author), Baker, D.G. (author), Vermetten, E. (author)In order to decrease the risk of developing stress-related disorders after military deployment, biological vulnerability factors should be identified. Neuropeptide Y (NPY) is a peptide neurotransmitter that is associated with modulation of the stress response. Using the data of two longitudinal prospective cohort studies (N = 892 and N = 2427),...article 2018
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Basten, T.G.H. (author), de Jong, C.A.F. (author), Graafland, F. (author), van 't Hof, J. (author)Acoustic signatures make naval platforms susceptible to detection by threat sensors. The variable operational conditions and lifespan of a platform cause variations in the acoustic signature. To deal with these variations, a real time signature monitoring capability is being developed, with advisory tools for signature management. Such a...conference paper 2015
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Guigas, B. (author), de Leeuw van Weenen, J.E. (author), van Leeuwen, N. (author), Simonis-Bik, A.M. (author), van Haeften, T.W. (author), Nijpels, G. (author), Houwing-Duistermaat, J.J. (author), Beekman, M. (author), Deelen, J. (author), Havekes, L.M. (author), Penninx, B.W.J.H. (author), Vogelzangs, N. (author), van 't Riet, E. (author), Dehghan, A. (author), Hofman, A. (author), Witteman, J.C. (author), Uitterlinden, A.G. (author), Grarup, N. (author), Jørgensen, T. (author), Witte, D.R. (author), Lauritzen, T. (author), Hansen, T. (author), Pedersen, O. (author), Hottenga, J. (author), Romijn, J.A. (author), Diamant, M. (author), Kramer, M.H.H. (author), Heine, R.J. (author), Willemsen, G. (author), Dekker, J.M. (author), Eekhoff, E.M. (author), Pijl, H. (author), de Geus, E.J. (author), Slagboom, P.E. (author), 't Hart, L.M. (author)Aims: Modulation of dopamine receptor D2 (DRD2) activity affects insulin secretion in both rodents and isolated pancreatic β-cells. We hypothesized that single nucleotide polymorphisms in the DRD2/ANKK1 locus may affect susceptibility to Type 2 diabetes in humans. Methods: Four potentially functional variants in the coding region of the DRD2...article 2014
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Cremer, H. (author), Bunnik, F.P.M. (author), Donders, T.H. (author), Hoek, W.Z. (author), Koolen-Eekhout, M. (author), Koolmees, H.H. (author), Lavooi, E. (author), TNO Bouw en Ondergrond (author)A 400-year sediment record from an 18 m deep scour hole lake (Haarsteegse Wiel) near the Meuse River in the Netherlands was investigated for past changes in water quality, flooding frequency and landscape change using geophysical, geochemical and micropaleontological information. The results are highly significant for determining long-term...article 2010
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Hogervorst, J.G.F. (author), Schouten, L.J. (author), Konings, E.J.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Background: Acrylamide is a probable human carcinogen, which is present in several heat-treatedfood s. In epidemiologic studies, positive associations with endometrial, ovarian, and renal cell cancer risk have been observed. The incidence of central nervous system tumors was increased upon acrylamide administration in drinking water to rats. In...article 2009
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TNO Kwaliteit van Leven (author), Gaisser, S. (author), Vignola-Gagné, E. (author), Hüsing, B. (author), Enzing, C. (author), van der Valk, T. (author)Against the background of a number of first drug-diagnostic co-products developed and introduce into the European market, European decision-makers feel impelled to react and position themselves in the field of personalized medicine. Their reactions cover a broad range, from the analysis of knowledge requirements for market approval to the need...article 2009
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van Leeuwen, D.M. (author), Pedersen, M. (author), Hendriksen, P.J.M. (author), Boorsma, A. (author), van Herwijnen, M.H.M. (author), Gottschalk, R.W.H. (author), Kirsch-Volders, M. (author), Knudsen, L.E. (author), Šrám, R.J. (author), Bajak, E. (author), van Delft, J.H.M. (author), Kleinjans, J.C.S. (author), TNO Kwaliteit van Leven (author)Differences in biological responses to exposure to hazardous airborne substances between children and adults have been reported, suggesting children to be more susceptible. Aim of this study was to improve our understanding of differences in susceptibility in cancer risk associated with air pollution by comparing genome-wide gene expression...article 2008
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Bos, J.E. (author), Damala, D. (author), Lewis, C. (author), Ganguly, A. (author), Turan, O. (author), TNO Defensie en Veiligheid (author)This paper explains part of the observed variability in passenger illness ratings aboard ships by gender, age and sickness history. Within the framework of a European project, 2840 questionnaires, gathered on several ships operating all over Europe, were analysed. Gender, age and sickness history all had a highly significant effect on...article 2007
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van den Brandt, P.A. (author), Goldbohm, R.A. (author), TNO Kwaliteit van Leven (author)Diet has been hypothesized to play a role in the etiology of gastrointestinal cancer for a long time. Initially, strong evidence of such effects was found in retrospective epidemiological studies. Dietary habits, in particular those from the distant past, are difficult to measure, however. Results from recent, prospective and larger studies of...article 2006
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Corthésy-Theulaz, I. (author), den Dunnen, J.T. (author), Ferré, P. (author), Geurts, J.M.W. (author), Müller, M. (author), van Belzen, N. (author), van Ommen, B. (author), TNO Kwaliteit van Leven (author)The interaction between the human body and nutrition is an extremely complex process involving multi-organ physiology with molecular mechanisms on all levels of regulation (genes, gene expression, proteins, metabolites). Only with the recent technology push have nutritional scientists been able to address this complexity. Both the challenges and...article 2005
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Knippels, L.M.J. (author), van Wijk, F. (author), Penninks, A.H. (author), TNO Voeding (author)Purpose of review This review summarizes selected articles on animal models of food allergy published in 2003. The research areas that are covered include mechanistic studies, the search for new therapies, as well as screening models for hazard identification of potential allergens. Recent findings Novel treatment options of both prevention and...article 2004
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TNO Voeding (author), Malan, D.D. (author), Scheele, C.W. (author), Buyse, J. (author), Kwakernaak, C. (author), Siebrits, F.K. (author), van der Klis, J.D. (author), Decuypere, E. (author)1. Male chickens of 7 genetic lines, consisting of two pure sire and two pure dam populations, a commercial broiler cross and two slow-growing chicken lines (Label Rouge, LR and Mechelse Koekoek, MK) were reared from 1 to 37 d of age. The chickens received a two-phase dietary regime and were subjected to low ambient temperature. 2. The...article 2003
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TNO Preventie en Gezondheid (author), Bayley, J.P. (author), Bakker, A.M. (author), Kaijzel, E.L. (author), Huizinga, T.W.J. (author), Verweij, C.L. (author)Objective. To assess the role of polymorphisms of the tumour necrosis factor (TNF) receptors, TNF-RI (p55) and TNF-RII (p75) in the susceptibility to and severity of rheumatoid arthritis (RA) in Dutch patients. Methods. A total of 319 consecutive RA patients, and a cohort of 90 female RA patients with detailed 12-yr follow-up were genotyped for...article 2003
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Rezaee, F. (author), Maas, A. (author), de Maat, M.P.M. (author), Verheijen, J.H. (author), Koopman, J. (author), Gaubius instituut TNO (author)Many epidemiological studies suggest that elevated plasma fibrinogen concentrations form one of the most important independent risk factors in blood for cardiovascular disease and particularly atherosclerosis in humans. To clarify the effect of genetic factors, diets and their interactions on plasma fibrinogen concentrations, we examined plasma...article 2002
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