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Sybesma, W. (author), Kort, R. (author), Lee, Y.K. (author)We describe factors promoting the exploration of locally sourced probiotics, targeting local populations to balance human needs and market opportunities. This would be particularly beneficial for people in developing countries, who generally lack access to affordable probiotics and are often exposed to poor hygiene conditions, toxic compounds,...article 2015
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Steevens, J. (author), Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author)Prospective epidemiologic data on vegetables and fruits consumption and risk of subtypes of esophageal and gastric cancer are sparse. We studied the association between vegetables and fruits consumption and risk of esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), gastric cardia adenocarcinoma (GCA) and gastric...article 2011
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Weisglas-Kuperus, N. (author), Hille, E.T.M. (author), Duivenvoorden, H.J. (author), Finken, M.J.J. (author), Wit, J.M. (author), van Buuren, S. (author), van Goudoever, J.B. (author), Verloove-Vanhorick, S.P. (author), TNO Kwaliteit van Leven (author)Objective: To examine the effect of intrauterine and neonatal growth, prematurity and personal and environmental risk factors on intelligence in adulthood in survivors of the early neonatal intensive care era. Methods: A large geographically based cohort comprised 94% of all babies born alive in the Netherlands in 1983 with a gestational age...article 2009
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van der Hoeven, B.L. (author), Pires, N.M.M. (author), Warda, H.M. (author), Putter, H. (author), Quax, P.H.A. (author), Schalij, M.J. (author), Jukema, J.W. (author), TNO Kwaliteit van Leven (author)Diabetes mellitus (DM) is a strong predictor of in-stent restenosis. This may be due to a higher level of vascular inflammation. We hypothesized that diabetic patients will benefit from dexamethasone-eluting stents, since local inflammation and consequently neointimal growth are suppressed and no systemic side effects will occur. Methods: 21...article 2008
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- TNO Kwaliteit van Leven (author), Bruil, J. (author), Detmar, S.B. (author) article 2005
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Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author), Blanquet, S. (author), Meunier, J.P. (author), Minekus, M. (author), Marol-Bonnin, S. (author), Alric, M. (author)The use of genetically engineered microorganisms such as bacteria or yeasts as live vehicles to carry out bioconversion directly in the digestive environment is an important challenge for the development of innovative biodrugs. A system that mimics the human gastrointestinal tract was combined with a computer simulation to evaluate the survival...article 2003
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van der Pal-de Bruin, K.M. (author), Graafmans, W. (author), Biermans, M.C.J. (author), Richardus, J.H. (author), Zijlstra, A.G. (author), Reefhuis, J. (author), Mackenbach, J.P. (author), Verloove-Vanhorick, S.P. (author), TNO Preventie en Gezondheid (author)Objectives This study concerns the possible effect of practice of prenatal screening of congenital anomalies followed by termination of pregnancy on the perinatal mortality between European countries. Methods Data of nine region-specific EUROCAT registries from five European countries were used to compare the pregnancy termination rate and...article 2002
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Zeegers, M.P.A. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objective: In a prospective cohort study among 120,852 adult subjects the authors investigated the associations between cigarette, cigar, pipe, environmental tobacco smoking (ETS), and bladder cancer. Methods: In 1986 all subjects completed a questionnaire on cancer risk factors. Follow-up for incident bladder cancer was established by linkage...article 2002
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Gaubius Instituut TNO (author), Westendorp, R. (author), Knook, D. (author), Kluft, C. (author), Droog, S. (author), Slagboom, P. (author), Heijmans, B. (author), Lagaay, A. (author), Gussekloo, J. (author)The common apolipoprotein E (APOE) alleles ε2, ε3, and ε4 are associated with the risk of dementia and cardiovascular disease. Recently, two functional variants (-219G/T and -491A/T) were identified in the promoter of the APOE gene that enable a further characterization of the role of the APOE locus in disease. We investigated the contribution...article 2002
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TNO Biomedical Instrumentation (author), Jellema, W.T. (author), Groeneveld, A.B.Johan (author), van Goudoever, J. (author), Wesseling, K.H. (author), Westerhof, N. (author), Lubbers, M.J. (author), Kesecioglu, J. (author), van Lieshout, J.J. (author)OBJECTIVE: The purposes of this study were to investigate the hemodynamic changes induced by intermittent manual lung hyperinflation (MHI) and to assess if these changes are adverse enough to warrant prohibition of MHI as a routine procedure in the care of patients with septic shock. DESIGN: The study's design was experimental prospective....article 2000
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Common paraoxonase gene variants, mortality risk and fatal cardiovascular events in elderly subjectsGaubius Instituut TNO (author), Heijmans, B.T. (author), Westendorp, R.G.J. (author), Lagaay, A.M. (author), Knook, D.L. (author), Kluft, C. (author), Slagboom, P.E. (author)Recent studies indicate that the enzyme paraoxonase may be an important modulator of cardiovascular disease risk because of its ability to protect LDL from oxidation. We tested for association between two functional variants of the paraoxonase gene (Met-55/Leu and Gln-192/Arg) and both all-cause mortality and fatal cardiovascular disease. This...article 2000
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van Helden, H.P.M. (author), Groen, B. (author), Moor, E. (author), Westerink, B.H.C. (author), Bruijnzeel, P.L.B. (author), Prins Maurits Laboratorium TNO (author)Current treatment of acute organophosphate (OP) poisoning includes a combined administration of a cholinesterase reactivator (oxime), a muscarinic receptor antagonist (atropine) and an anticonvulsant (diazepam). This treatment is not adequate since it does not prevent neuronal brain damage and incapacitation. Here, as in a recent review it is...article 1998
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Reijneveld, S.A. (author), TNO Preventie en Gezondheid (author)Background. In general, poor health and lifestyles occur more frequently among individuals of low socioeconomic status (SES) and in deprived areas. An explanation for the latter may simply be the on average lower SES of residents of these areas. It is possible, however, that living in a deprived area contributes to poor health and lifestyles....article 1998
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Prins Maurits Laboratorium TNO (author), van Helden, H.P.M. (author), Kuijpers, W.C. (author), Langerwerf, P.E.J. (author), Langen, R.C.J. (author), Haagsman, H.P. (author), Bruijnzeel, P.L.B. (author)Curosurf, a natural lung surfactant, is considered a potential candidate for improving the treatment of acute respiratory distress syndrome (ARDS). To investigate this in a rat model of early-stage ARDS, Curosurf (62.5, 125 or 250 mg·kg-1) was administered by intratracheal bolus at 10 or 24 h following an intratracheal lipopolysaccharide (LPS; 1...article 1998
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van der Bom, J.G. (author), de Knijff, P. (author), Haverkate, F. (author), Bots, M.L. (author), Meijer, P. (author), de Jong, P.T.V.M. (author), Hofman, A. (author), Kluft, C. (author), Grobbee, D.E. (author), Gaubius Instituut TNO (author)Background: Impaired fibrinolytic capacity, as assessed by euglobulin clot lysis time or plasma concentration of fibrinolytic parameters, has been associated with an increased risk of myocardial infarction (MI). We studied the association of a polymorphism in the gene for TPA and of plasma concentrations of TPA (antigen and activity) with the...article 1997
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Gaubius Instituut TNO (author), Ganesh, S. (author), Sier, C.F.M. (author), Heerding, M.M. (author), van Krieken, J.H.J.M. (author), Griffioen, G. (author), Welvaart, K. (author), van de Velde, C.J.H. (author), Verheijen, J.H. (author), Lamers, C.B.H.W. (author), Verspaget, H.W. (author)Despite the advances in pre-, peri- andpost-operative medical care of colorectal carcinoma patients, the prognosis has improved only marginally over recent decades. Thus, additional prognostic indicators would be of great clinical value to select patients for adjuvant therapy. In previous studies we found that colorectal carcinomas have a marked...article 1997
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TNO Preventie en Gezondheid Gaubius Instituut TNO (author), Sier, C.F.M. (author), Kubben, F.J.G.M. (author), Ganesh, S. (author), Heerding, M.M. (author), Griffioen, G. (author), Hanemaaijer, R. (author), van Krieken, J.H.J.M. (author), Lamers, C.B.H.W. (author), Verspaget, H.W. (author)Proteinases are involved in tumour invasion and metastasis. Several matrix metalloproteinases (MMPs) have been shown to be increased in various human carcinomas. We assessed the levels of MMP-2 (gelatinase A) and MMP-9 (gelatinase B) in 50 gastric carcinomas and corresponding mucosa using quantitative gelatin zymography. Both MMP levels were...article 1996
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- TNO Preventie en Gezondheid (author), Hirasing, R.A. (author), Bohm, F.J. (author), Reeser, H.M. (author), Oei, Y.B. (author), Vaandrager, G.J. (author), Verloove-Venhorick, S.P. (author) article 1995
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Groen, K. (author), Breimer, D.D. (author), Jansen, E.J. (author), van Bezooijen, C.F.A. (author), Gaubius Instituut TNO (author)The influence of aging on the metabolism of antipyrine (AP) and hexobarbital enantiomers (R-HB and S-HB) with and without phenobarbital (PB) induction was investigated in a longitudinal study in rats aged 6, 12, 24 and 30 months. The metabolic clearances of AP (Cl(m AP)), R-HB (Cl(m R-HB)) and S-HB (Cl(m S-HB)) were used as indicators for P450...article 1994
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Hille, E.T.M. (author), den Ouden, A.L. (author), Bauer, L. (author), van den Oudenrijn, C. (author), Brand, R. (author), Verloove-Vanhorick, S.P. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)To assess the impact of both perinatal disorders and developmental problems identified at preschool age on school performance, we followed a virtually complete birth cohort of very premature (<32 completed weeks of gestation) and very low birth weight infants until they were 9 years of age. In 84% of the survivors (n = 813), data on school...article 1994
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