Searched for: subject:"Support%2C%5C+Non%5C-U.S.%5C+Gov%27t"
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Anthony, S. (author), Buitendijk, S.E. (author), Dorrepaal, C.A. (author), Lindner, K. (author), Braat, D.D.M. (author), den Ouden, A.L. (author)
Background: The percentage of children born after IVF will continue to increase due to demographic changes such as increasing maternal age and new developments in assisted reproduction techniques. IVF conceptions may carry an increased risk of congenital malformations. Methods: We compared overall and specific congenital malformation rates...
article 2002
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Rezaee, F. (author), Maas, A. (author), de Maat, M.P.M. (author), Verheijen, J.H. (author), Koopman, J. (author), Gaubius instituut TNO (author)
Many epidemiological studies suggest that elevated plasma fibrinogen concentrations form one of the most important independent risk factors in blood for cardiovascular disease and particularly atherosclerosis in humans. To clarify the effect of genetic factors, diets and their interactions on plasma fibrinogen concentrations, we examined plasma...
article 2002
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Cnubben, N.H.P. (author), Elliott, G.R. (author), Hakkert, B.C. (author), Meuling, W.J.A. (author), van de Sandt, J.J.M. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
The validity of in vitro and in vivo methods for the prediction of percutaneous penetration in humans was assessed using the fungicide ortho-phenylphenol (OPP) (log Po/w 3.28, MW 170.8, solubility in water 0.7 g/L). In vivo studies were performed in rats and human volunteers, applying the test compound to the dorsal skin and the volar aspect of...
article 2002
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de Groot, J. (author), Bank, R.A. (author), Tchetverikov, I. (author), Verzijl, N. (author), TeKoppele, J.M. (author), Gaubius Instituut (author)
Osteoarthritis is a disabling joint disease that is characterized by the progressive destruction of articular cartilage. Diagnosis is based on clinical symptoms in combination with radiography, which is relatively insensitive and provides only an indication of accumulated damage. Alternative methods, such as molecular markers, are therefore...
article 2002
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Szabó, C. (author), Jansman, A.J.M. (author), Babinszky, L. (author), Kanis, E. (author), Verstegen, M.W.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The effects of four protein sources (soybean meal, sunflower meal, pea, and fish meal as the main protein source) and three apparent ileally digestible Lys:DE ratios (0.50, 0.43, 0.36 and 0.42, 0.36, 0.30 g Lys/MJ DE for 30 to 60 kg BW and 60 to 105 kg BW, respectively) in pig diets on growing-finishing performance, and carcass and meat quality...
article 2001
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Maas, W.J.M. (author), Leeman, W.R. (author), Groten, J.P. (author), van de Sandt, J.J.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Precision-cut liver slices are frequently used to study hepatic toxicity and metabolism of xenobiotics in vitro. Successful cryopreservation techniques will enhance an efficient and economic use of scarcely available (human) liver tissue. For primary hepatocytes, slow freezing has been accepted as the best approach towards successful...
article 2000
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Kerstholt, J.H. (author), Passenier, P.O. (author)
Automation has changed the role of human operators from direct manual control to supervision. Their main task is to monitor whether system performance remains within pre-specified ranges and intervention is only required in unusual situations. One of the consequences is a loss of situation awareness, which significantly affects performance in...
article 2000
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Kromhout, H. (author), Hoek, F. (author), Uitterhoeve, R. (author), Huijbers, R. (author), Overmars, R.F. (author), Anzion, R. (author), Vermeulen, R. (author)
Dermal exposure to anti-neoplastic drugs has been suggested as a potentially important route of exposure of hospital workers. Three small-scale workplace surveys were carried out in several hospitals focusing on contamination by leakage from IV infusion systems; contamination by spilled urine of patients treated with anti-neoplastic drugs and...
article 2000
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Kroon, M.E. (author), Koolwijk, P. (author), van der Vecht, B. (author), van Hinsbergh, V.W.M. (author), Gaubius Instituut TNO (author)
Hypoxia stimulates angiogenesis, the formation of new blood vessels. This study evaluates the direct effect of hypoxia (1% oxygen) on the angiogenic response of human microvascular endothelial cells (hMVECs) seeded on top of a 3-dimensional fibrin matrix, hMVECs stimulated with fibroblast growth factor-2 (FGF-2) or vascular endothelial growth...
article 2000
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TNO Biomedical Instrumentation (author), Jellema, W.T. (author), Groeneveld, A.B.Johan (author), van Goudoever, J. (author), Wesseling, K.H. (author), Westerhof, N. (author), Lubbers, M.J. (author), Kesecioglu, J. (author), van Lieshout, J.J. (author)
OBJECTIVE: The purposes of this study were to investigate the hemodynamic changes induced by intermittent manual lung hyperinflation (MHI) and to assess if these changes are adverse enough to warrant prohibition of MHI as a routine procedure in the care of patients with septic shock. DESIGN: The study's design was experimental prospective....
article 2000
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Dirven, H.A.A.M. (author), Megens, L. (author), Oudshoorn, M.J. (author), Dingemanse, M.A. (author), van Ommen, B. (author), van Bladeren, P.J. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
Development of drug resistance against alkylating cytostatic drugs has been associated with higher intracellular concentrations of glutathione (GSH) and increased expression of glutathione S-transferase (GST) enzymes. Therefore, enhanced detoxification by the glutathione/glutathione S-transferase pathway has been proposed as a major factor in...
article 1995
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Twisk, J. (author), Hoekman, M.F.M. (author), Lehmann, E.M. (author), Meijer, P. (author), Mager, W.H. (author), Princen, H.M.G. (author), TNO Preventie en Gezondheid (author)
Evidence from in vivo studies indicates that the bile acid pool and bile acid excretion are increased in humans with diabetes mellitus and in experimental diabetic animals, and that both parameters return to normal levels after administration of insulin. To investigate the biochemical background of these changes, the effects of insulin on bile...
article 1995
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Lombardi, P. (author), Sijbrands, E.J.G. (author), van de Giessen, K. (author), Smelt, A.H.M. (author), Kastelein, J.J.P. (author), Frants, R.R. (author), Havekes, L.M. (author), Gaubius Instituut TNO (author)
Familial hypercholesterolemia (FH) results from mutations in the low density lipoprotein receptor (LDLR) gene. We applied denaturing gradient gel electrophoresis (DGGE) to screen for sequence variations in the coding and splice site consensus sequences of the LDLR gene. For amplification of each exon by the polymerase chain reaction (PCR),...
article 1995
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Wolterbeek, A.P.M. (author), Roggeband, R. (author), Baan, R.A. (author), Feron, V.J. (author), Rutten, A.A.J.J.L. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
Vitamin A and β-carotene protect against respiratory tract cancer by inhibiting the formation of DNA damage and controlling cellular proliferation and differentiation, Recently, it has been shown that the p53 tumor-suppressor gene plays a crucial role in the etiology of respiratory tract cancer. In the present study, we investigated the...
article 1995
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Visser, C.J.T. (author), Meijers, M. (author), van Garderen-Hoetmer, A. (author), Klijn, J.G.M. (author), Foekens, J.A. (author), Woutersen, R.A. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
The present 12-month study was carried out to investigate the effects of the aromatase inhibitor aminoglutethimide, alone and in combination with orchiectomy, on pancreatic carcinogenesis in azaserine-treated rats and N-nitrosobis(2-oxopropyl)amine-treated hamsters. Treatment of the animals started 4 months after the last injection with the...
article 1995
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Wanker, E. (author), Leer, R.J. (author), Pouwels, P.H. (author), Schwab, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Two Lactobacillus-Escherichia coli shuttle vectors, harbouring the levanase gene from Bacillus subtilis under the control of its own promoter (pLPEW1) or behind the E. coli tac promoter (pE-SIEW2), were constructed. Lactobacillus plantarum showed the same growth characteristics on selective plates and in liquid media containing inulin, after...
article 1995
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van Hemmen, J.J. (author), Brouwer, D.H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The methods for the dermal exposure assessment vary in their complexity and are in some sense complementary to each other. The most easy-to-use methods involve a pseudo-skin-approach, such as gloves and removal by washing. In some cases generic modelling appears to be possible. The experimental methods can indicate and even quantitate the...
article 1995
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van Ree, J.H. (author), Hofker, M.H. (author), van den Broek, J.A.A. (author), van Deursen, J.M.A. (author), van der Boom, H. (author), Frants, R.R. (author), Wieringa, B. (author), Havekes, L.M. (author), Gaubius Instituut TNO (author)
The function of apolipoprotein (apo) C1 in vivo is not well understood. From in vitro studies it has been reported that an excess of apoC1 relative to apoE inhibits receptor-mediated uptake of remnant lipoproteins. In order to gain a better understanding of the role of apoC1 in lipoprotein metabolism in vivo, we have generated apoC1-deficient...
article 1995
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Twisk, J. (author), de Wit, E.C.M. (author), Princen, H.M.G. (author), TNO Preventie en Gezondheid (author)
In previous work we have demonstrated suppression of cholesterol 7α-hydroxylase by bile acids at the level of mRNA and transcription, resulting in a similar decline in bile acid synthesis in cultured rat hepatocytes. In view of the substantial contribution of the 'alternative' or '27-hydroxylase' route to total bile acid synthesis, as...
article 1995
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Appel, M.J. (author), Woutersen, R.A. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
In the present study the chemopreventive potential of 25% fat (HF) diets containing 2 wt% linoleic acid (LA) and including 0.0, 1.2, 2.4, 4.7, 7.1 or 9.4 wt% dietary fish oil (MaxEPA) has been investigated using the N-nitrosobis(2-oxopropyl)amine (BOP)-hamster model for pancreatic cancer. The number of pancreatic borderline lesions (BLL) was...
article 1995
Searched for: subject:"Support%2C%5C+Non%5C-U.S.%5C+Gov%27t"
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