Searched for: subject%3A%22Substances%22
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van den Bossche, S. (author), Dhondt, S. (author), Fransman, W. (author)
The world of work is changing at an ever-increasing rate. Digitalisation, with the COVID-19 pandemic as a catalyst, climate change and demographic developments are causing shifts in the labour market. Some jobs are changing, others are disappearing and new jobs are taking their place. These changes offer opportunities, but are at the same time...
other 2022
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van Zomeren, A. (author), Koper, R. (author), Dijkstra, J.J. (author), Comans, R.N.J. (author)
Analysis of dissolved organic carbon (DOC) is widely used to quantify the sum of organic carbon species in water. Analyzers based on wet chemical oxidation (WCO) usually have a relatively low detection limit (±1 μg of C/L) and are, therefore, well suited for analyses of DOC in environmental samples (e.g., surface water, groundwater, or seawater)...
article 2021
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Goede, H. (author), Kuijpers, E. (author), Krone, T. (author), le Feber, M. (author), Franken, R. (author), Fransman, W. (author), Duyzer, J. (author), Pronk, A. (author)
This commentary explores the use of high-resolution data from new, miniature sensors to enrich models that predict exposures to chemical substances in the workplace. To optimally apply these sensors, one can expect an increased need for new models that will facilitate the interpretation and extrapolation of the acquired time-resolved data. We...
article 2021
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Franken, R. (author), Shandilya, N. (author), Marquart, H. (author), McNally, K. (author), Fransman, W. (author)
Measured data are generally preferred to modelled estimates of exposure. Grouping and read-across is already widely used and accepted approach in toxicology, but an appropriate approach and guidance on how to use existing exposure measurement data on one substance and work situation for another substance and/or work situation is currently not...
article 2020
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Meima, M. (author), Kuijpers, E. (author), van Berg, C. (author), Kruizinga, A. (author), van Kesteren, N. (author), Spaan, S. (author)
This report is the final output of a major project that was commissioned to address exposure to biological agents in the workplace and the related health effects. The study included a scientific literature review, interviews with experts, focus group sessions and a stakeholder workshop. The report presents a consolidated summary of the outcomes...
report 2020
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Vink, R.M. (author), van Dommelen, P. (author), van der Pal, S.M. (author), Eikhout, I. (author), Pannebakker, F.D. (author), Klein Velderman, M. (author), Haagmans, M. (author), Mulder, T. (author), Dekker, M. (author)
Background Adverse Childhood Experiences (ACEs) may have a life-long impact on mental health and are related to physical disease, such as diabetes and cardiovascular diseases in adulthood. Research on ACEs suffers from recall bias when performed with adults. Objective To estimate the prevalence of ACEs and the interrelationships between ACEs as...
article 2019
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van Egmond, M.P. (author), Venema, A. (author), Bakhuys Roozeboom, M.C. (author), Weyers, M.M. (author), Franken, R.A. (author), Fransman, W. (author), Hermans, L.M. (author), Schaddelee-Scholten, B.J.W. (author), Schelvis, R.M.C. (author), Spaan, S. (author)
public lecture 2019
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Escher, S.E. (author), Kamp, H. (author), Bennekou, S.H. (author), Bitsch, A. (author), Fisher, C. (author), Graepel, R. (author), Hengstler, J.G. (author), Herzler, M. (author), Knight, D. (author), Leist, M. (author), Norinder, U. (author), Ouédraogo, G. (author), Pastor, M. (author), Stuard, S. (author), White, A. (author), Zdrazil, B. (author), van de Water, B. (author), Kroese, D. (author)
Read-across is one of the most frequently used alternative tools for hazard assessment, in particular for complex endpoints such as repeated dose or developmental and reproductive toxicity. Read-across extrapolates the outcome of a specific toxicological in vivo endpoint from tested (source) compounds to “similar” (target) compound(s). If...
article 2019
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Jedynska, A. (author), Kuijpers, E. (author), van Berg, C. (author), Kruizinga, A. (author), Meima, M. (author), Spaan, S. (author)
This report forms part of a major project to address the risks posed by biological agents in the workplace. The aim of the project is to raise awareness of exposures to these hazards at work, provide more information on the related health problems and support efforts to prevent them. The report presents the results of a scientific literature...
report 2019
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Kasiotis, K.M. (author), Tsakirakis, A.N. (author), Richard Glass, C. (author), Charistou, A.N. (author), Anastassiadou, P. (author), Gerritsen-Ebben, R. (author), Machera, K. (author)
A dislodgeable foliar residue study was conducted in greenhouse pepper and tomato on the island of Crete, Greece, following the spray application of an SC insecticide (with active substance (a.s.) tebufenozide) and an EC fungicide (a.s. bupirimate). Furthermore, for the assessment of worker exposure to pesticides – as a result of re-entering the...
article 2017
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Marquart, H. (author), Franken, R. (author), Goede, H. (author), Fransman, W. (author), Schinkel, J. (author)
The ECETOC TRA model (presently version 3.1) is often used to estimate worker inhalation and dermal exposure in regulatory risk assessment. The dermal model in ECETOC TRA has not yet been validated by comparison with independent measured exposure levels. This was the goal of the present study. Measured exposure levels and relevant contextual...
article 2017
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Hoytema van Konijnenburg, E.M. (author), Diderich, H.M. (author), Teeuw, A.H. (author), Klein Velderman, M. (author), Oudesluys-Murphy, A.M. (author), van der Lee, J.H. (author)
To improve identification of child maltreatment, a new policy (‘Hague protocol’) was implemented in hospitals in The Netherlands, stating that adults attending the hospital emergency department after intimate partner violence, substance abuse or a suicide attempt should be asked whether they care for children. If so, these children are referred...
article 2016
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Plamboeck, A.H. (author), Stöven, S. (author), Duarte Davidson, R. (author), Fykse, E.M. (author), Griffiths, M. (author), Nieuwenhuizen, M.S. (author), Rivier, C. (author), van der Schans, M.J. (author)
The threat of terrorists using CBRN agents continues to pose a risk of mass casualties and severe disruption of societal functions in Europe. Standardisation of crisis management activities is one important step towards effective national and international interoperability and increased resilience. Understanding which CBRN agents are involved in...
article 2016
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van der Burg, B. (author), Pieterse, B. (author), Rorije, E. (author), Lewin, G. (author), van der Linden, S.C. (author), Man, H.Y. (author), Piersma, A.H. (author), Mangelsdorf, I. (author), Wolterbeek, A.P.M. (author), Kroese, E.D. (author), van Vugt-Lussenburg, B.M.A. (author)
There is a great need for alternative testing methods for reproductive toxicants that are practical, fast, cost-effective and easy to interpret. Previously we followed a pragmatic approach using readily available tests, which was successful in predicting reproductive toxicity of chemicals [13]. This initial battery still contained apical tests...
article 2015
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Koster, S. (author), Leeman, W.R. (author), Verheij, E.R. (author), Dutman, A.E. (author), van Stee, L.L.P. (author), Munch Nielsen, L. (author), Ronsmans, S. (author), Noteborn, H. (author), Krul, L. (author)
A main challenge in food safety research is to demonstrate that processing of foodstuffs does not lead to the formation of substances for which the safety upon consumption might be questioned. This is especially so since food is a complex matrix in which the analytical detection of substances, and consequent risk assessment thereof, is difficult...
article 2015
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Kroese, E.D. (author), Bosgra, S. (author), Buist, H.E. (author), Lewin, G. (author), van der Linden, S.C. (author), Man, H.Y. (author), Piersma, A.H. (author), Rorije, E. (author), Schulpen, S.H.W. (author), Schwarz, M. (author), Uibel, F. (author), van Vugt-Lussenburg, B.M.A. (author), Wolterbeek, A.P.M. (author), van der Burg, B. (author)
Previously we showed a battery consisting of CALUX transcriptional activation assays, the ReProGlo assay, and the embryonic stem cell test, and zebrafish embryotoxicity assay as 'apical' tests to correctly predict developmental toxicity for 11 out of 12 compounds, and to explain the one false negative [7]. Here we report on applying this battery...
article 2015
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Terwoert, J. (author), Kersting, K. (author)
Products based on epoxy resins as a binder have become popular in various settings, among which the construction industry and in windmill blade production, as a result of their excellent technical properties. However, due to the same properties epoxy products are a notorious cause of allergic skin disease among workers. In addition, constituents...
other 2014
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Koster, S. (author), Rennen, M. (author), Leeman, W. (author), Houben, G. (author), Muilwijk, B. (author), van Acker, F. (author), Krul, L. (author)
One of the main challenges in food contact materials research is to prove that the presence of non-intentionally added substances (NIAS) is not a safety issue. Migration extracts may contain many unknown substances present at low concentrations. It is difficult and time-consuming to identify all these potential NIAS and concurrently to assess...
article 2014
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Terwoert, J. (author)
Too often, measures to control workers’ exposure to dangerous substances are taken on an ‘ad-hoc’ basis. Existing processes, procedures and routines are taken for granted, and ‘end-of-pipe’ solutions are installed. In many cases, one relies on the use of personal protective equipment. This may lead to sub-optimal levels of control, for example...
other 2014
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Terwoert, J. (author)
Irritants – in this article to be understood as being chemical irritants – are substances that may cause injuries to the skin, the eyes or the airways after a single exposure. These injuries may range from small, initially invisible injuries after exposure to weak irritants up to chemical burns after exposure to very strong irritants (i.e....
other 2014
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