Searched for: subject:"Structure%5C-Activity%5C+Relationship"
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Buist, H.E. (author), Devito, S. (author), Goldbohm, R.A. (author), Stierum, R.H. (author), Venhorst, J. (author), Kroese, E.D. (author)
Carbon capture and storage (CCS) technologies are considered vital and economic elements for achieving global CO2 reduction targets, and is currently introduced worldwide (for more information on CCS, consult for example the websites of the International Energy Agency (http://www.iea.org/topics/ccs/) and the Global CCS Institute (http://www...
article 2015
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Tluczkiewicz, I. (author), Buist, H.E. (author), Martin, M.T. (author), Mangelsdorf, I. (author), Escher, S.E. (author)
The present report describes a strategy to refine the current Cramer classification of the TTC concept using a broad database (DB) termed TTC RepDose. Cramer classes 1-3 overlap to some extent, indicating a need for a better separation of structural classes likely to be toxic, moderately toxic or of low toxicity.Groups of structurally similar...
article 2011
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Molhoek, E.M. (author), den Hertog, A.L. (author), de Vries, A.M.B.C. (author), Nazmi, K. (author), Veerman, E.C.I. (author), Hartgers, F.C. (author), Yazdanbakhsh, M. (author), Bikker, F.J. (author), van der Kleij, D. (author), TNO Defensie en Veiligheid (author)
Cathelicidins are effector molecules of the innate host defense system that establish an antimicrobial barrier at epithelial interfaces. The human cathelicidin LL-37, in addition to its antimicrobial activity, also exhibits immunomodulatory effects, such as inhibition of pro-inflammatory responses to bacterial LPS in human monocytic cells. In...
article 2009
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de Jong, E. (author), Louisse, J. (author), Verwei, M. (author), Blaauboer, B.J. (author), van de Sandt, J.J.M. (author), Woutersen, R.A. (author), Rietjens, I.M.C.M. (author), Piersma, A.H. (author), TNO Kwaliteit van Leven (author)
The embryonic stem cell test (EST) has been proposed as an in vitro assay that might reduce animal experimentation in regulatory developmental toxicology. So far, evaluation of the EST was not performed using compounds within distinct chemical classes. Evaluation within a distinct class of chemically related compounds can define the usefulness...
article 2009
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Tuin, A.W. (author), Grotenbreg, G.M. (author), Spalburg, E. (author), de Neeling, A.J. (author), Mars-Groenendijk, R.H. (author), Noort, D. (author), van der Marel, G.A. (author), Overkleeft, H.S. (author), Overhand, M. (author), TNO Defensie en Veiligheid (author)
Loloatin C is a cyclic cationic antimicrobial peptide which is active against Gram positive as well as certain Gram negative bacteria. Unfortunately, it is equally potent against human erythrocytes. To probe the structure-activity relationship of this promising antibiotic peptide, amino acid substitution and/or incorporation of a constraint...
article 2009
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van Leeuwen, K. (author), Schultz, T.W. (author), Henry, T. (author), Diderich, B. (author), Veith, G.D. (author), TNO Kwaliteit van Leven (author)
Hazard assessments of chemicals have been limited by the availability of test data and the time needed to evaluate the test data. While available data may be inadequate for the majority of industrial chemicals, the body of existing knowledge for most hazards is large enough to permit reliable estimates to be made for untested chemicals without...
article 2009
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van Boxtel, E.L. (author), van den Broek, L.A.M. (author), Koppelman, S.J. (author), Gruppen, H. (author), TNO Kwaliteit van Leven (author)
Legumin proteins Ara h 3 from peanuts and glycinin from soybeans are increasingly described as important allergens. The stability of an allergen's IgE binding capacity towards heating and digestion is considered an important characteristic for food allergens. We investigated the effects of heating and digestion on the IgE binding of Ara h 3 and...
article 2008
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Zvinavashe, E. (author), van den Berg, H. (author), Soffers, A.E.M.F. (author), Vervoort, J. (author), Freidig, A. (author), Murk, A.J. (author), Rietjens, I.M.C.M. (author), TNO Kwaliteit van Leven (author)
Quantitative structure-activity relationship (QSAR) models are expected to play a crucial role in reducing the number of animals to be used for toxicity testing resulting from the adoption of the new European Union chemical control system called Registration, Evaluation, and Authorization of Chemicals (REACH). The objective of the present study...
article 2008
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Loizou, G. (author), Spendiff, M. (author), Barton, H.A. (author), Bessems, J. (author), Bois, F.Y. (author), d'Yvoire, M.B. (author), Buist, H. (author), Clewell III, H.J. (author), Meek, B. (author), Gundert-Remy, U. (author), Goerlitz, G. (author), Schmitt, W. (author), TNO Kwaliteit van Leven (author), KvL (author)
The increasing use of tissue dosimetry estimated using pharmacokinetic models in chemical risk assessments in various jurisdictions necessitates the development of internationally recognized good modelling practice (GMP). These practices would facilitate sharing of models and model evaluations and consistent applications in risk assessments....
article 2008
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Bouwman, T. (author), Cronin, M.T. (author), Bessems, J.G. (author), van de Sandt, J.J. (author), TNO Kwaliteit van Leven (author)
The new regulatory framework REACH (Registration, Evaluation, and Authorisation of Chemicals) foresees the use of non-testing approaches, such as read-across, chemical categories, structure-activity relationships (SARs) and quantitative structure-activity relationships (QSARs). Although information on skin absorption data are not a formal...
article 2008
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Freidig, A.P. (author), Dekkers, S. (author), Verwei, M. (author), Zvinavashe, E. (author), Bessems, J.G.M. (author), van de Sandt, J.J.M. (author), TNO Kwaliteit van Leven (author)
Future EU legislations enforce a fast hazard and risk assessment of thousands of existing chemicals. If conducted by means of present data requirements, this assessment will use a huge number of test animals and will be neither cost nor time effective. The purpose of the current research was to develop methods to increase the acceptability of in...
article 2007
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Kimber, I. (author), Agius, R. (author), Basketter, D.A. (author), Corsini, E. (author), Cullinan, P. (author), Dearman, R.J. (author), Gimenez-Arnau, E. (author), Greenwell, L. (author), Hartung, T. (author), Kuper, F. (author), Maestrelli, P. (author), Roggen, E. (author), Rovida, C. (author), Casati, S. (author), TNO Kwaliteit van Leven (author)
article 2007
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Boerboom, A.M.J.F. (author), Vermeulen, M. (author), van der Woude, H. (author), Bremer, B.I. (author), Lee-Hilz, Y.Y. (author), Kampman, E. (author), van Bladeren, P.J. (author), Rietjens, I.M.C.M. (author), Aarts, J.M.M.J.G. (author), TNO Kwaliteit van Leven (author)
The electrophile-responsive element (EpRE) is a transcriptional enhancer involved in cancer-chemoprotective gene expression modulation by certain food components. Two stably transfected luciferase reporter cell lines were developed, EpRE(hNQO1)-LUX and EpRE(mGST-Ya)-LUX, based on EpRE sequences from the human NAD(P)H:quinone oxidoreductase ...
article 2006
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van Hijum, S.A.F.T. (author), Kralj, S. (author), Ozimek, L.K. (author), Dijkhuizen, L. (author), van Geel-Schutten, G.H. (author), TNO Kwaliteit van Leven (author)
Lactic acid bacteria (LAB) employ sucrase-type enzymes to convert sucrose into homopolysaccharides consisting of either glucosyl units (glucans) or fructosyl units (fructans). The enzymes involved are labeled glucansucrases (GS) and fructansucrases (FS), respectively. The available molecular, biochemical, and structural information on sucrase...
article 2006
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Zvinavashe, E. (author), Murk, A.J. (author), Vervoort, J. (author), Soffers, A.E.M.F. (author), Freidig, A. (author), Rietjens, I.M.C.M. (author), TNO Kwaliteit van Leven (author)
Fifteen experimental literature data sets on the acute toxicity of substituted nitrobenzenes to algae (Scenedesmus obliquus, Chlorella pyrenoidosa, C. vulgaris), daphnids (Daphnia magna, D. carinata), fish (Cyprinus carpio, Poecilia reticulata), protozoa (Tetrahymena pyriformis), bacteria (Phosphobacterium phosphoreum), and yeast (Saccharomyces...
article 2006
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Eskes, C. (author), Bessou, S. (author), Bruner, L. (author), Curren, R. (author), Harbell, J. (author), Jones, P. (author), Kreiling, R. (author), Liebsch, M. (author), McNamee, P. (author), Pape, W. (author), Prinsen, M.K. (author), Seidle, T. (author), Vanparys, P. (author), Worth, A. (author), Zuang, V. (author), TNO Kwaliteit van Leven (author)
article 2005
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Zuang, V. (author), Alonso, M.A. (author), Botham, P.A. (author), Eskes, C. (author), Fentem, J. (author), Liebsch, M. (author), van de Sandt, J.J.M. (author), TNO Kwaliteit van Leven (author)
article 2005
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Maurici, D. (author), Aardema, M. (author), Corvi, R. (author), Kleber, M. (author), Krul, C.A.M. (author), Laurent, C. (author), Loprieno, N. (author), Pasanen, M. (author), Pfuhler, S. (author), Phillips, B. (author), Sabbioni, E. (author), Sanner, T. (author), Vanparys, P. (author), TNO Kwaliteit van Leven TNO Voeding (author)
article 2005
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Maurici, D. (author), Aardema, M. (author), Corvi, R. (author), Kleber, M. (author), Krul, C.A.M. (author), Laurent, C. (author), Loprieno, N. (author), Pasanen, M. (author), Pfuhler, S. (author), Phillips, B. (author), Prentice, D. (author), Sabbioni, E. (author), Sanner, T. (author), Vanparys, P. (author), TNO Kwaliteit van Leven (author)
article 2005
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Netzeva, T.I. (author), Worth, A.P. (author), Aldenberg, T. (author), Benigni, R. (author), Cronin, M.T.D. (author), Gramatica, P. (author), Jaworska, J.S. (author), Kahn, S. (author), Klopman, G. (author), Marchant, C.A. (author), Myatt, G. (author), Nikolova-Jeliazkova, N. (author), Patlewicz, G.Y. (author), Perkins, R. (author), Roberts, D.W. (author), Schultz, T.W. (author), Stanton, D.T. (author), van de Sandt, J.J.M. (author), Tong, W. (author), Veith, G. (author), Yang, C. (author), TNO Kwaliteit van Leven (author)
article 2005
Searched for: subject:"Structure%5C-Activity%5C+Relationship"
(1 - 20 of 49)

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