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Singh, A. (author), Fokker, P.A. (author)This work is an extension of the time-resolved poro-elasto-plastic MohrCoulomb model by Fokker et al to include a more realistic constitutive model. Experiments on Slochteren sandstone revealed that the inelastic deformation contributes significantly in compressive deformation almost in all stages of loading and instigated the development of a...article 2021
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Wassing, B.B.T. (author), Gan, Q. (author), Candela, T. (author), Fokker, P.A. (author)Enhanced Geothermal Systems (EGS) involve hydraulic stimulation of the permeability of deep low-permeable rock formations. This causes the reactivation and opening of pre-existing natural fracture networks and the formation of new fractures. During hydraulic stimulation, injection pressures at the bottom of the injection well can reach...article 2021
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Fokker, P.A. (author), Singh, A. (author), Wassing, B.B.T. (author)Wellbore stability problems and stimulation operations call for models helping in understanding the subsurface behaviour and optimizing engineering performance. We present a fast, iteratively coupled model for the flow and mechanical behaviour that employs a time-sequential approach. Updates of pore pressure are calculated in a timestepping...article 2020
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Boersma, A. (author), Wang, Y. (author), Bäumer, S.M.B. (author), Lucas, P. (author), Willekers, R.W. (author), Halpin, A. (author), Gomez Rivas, J. (author), Hendriks, N. (author), den Toonder, J. (author)Stimulated Emission Depletion (STED)lithography is generally recognized as a very promising tool to overcome the Abbe diffraction limit and manufacture 3D submicron features using a mask-less lithography step. It has been shown to be able to create 100 nm resolution, 10 nm feature size features in a polymer resin. However, STED is not widely...other 2019
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Avsin, N. (author), Vandenberghe, J. (author), van Balen, R. (author), Klyak, N.G. (author), Oztürk, T. (author)Climate and tectonics effect the fluvial evolution of the Mediterranean Mut basin. The basin contains a river terrace staircase of 16 levels (T16-T1) ranging from 365 to 10A m above the current Goksu River in its middle and lower sections. These river terraces records tectonic uplift in the Mut basin. Optically stimulated luminescence (OSL)...conference paper 2019
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Kuiper, O.X. (author), Bos, J.E. (author), Diels, C. (author), Cammaerts, K. (author)We investigated whether motion sickness analogous to carsickness can be studied in a moving base simulator, despite the limited motion envelope. Importantly, to avoid simulator sickness, vision outside the simulator cabin was restricted. Participants (N = 16) were exposed blindfolded to 15-min lateral sinusoidal motion at 0.2 Hz and 0.35 Hz on...article 2019
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Hofmann, H. (author), Zimmermann, G. (author), Farkas, M. (author), Huenges, E. (author), Zang, A. (author), Leonhardt, M. (author), Kwiatek, G. (author), Martinez-Garzon, P. (author), Bohnhoff, M. (author), Min, K.B. (author), Fokker, P. (author), Westaway, R. (author), Bethmann, F. (author), Meier, P. (author), Yoon, K.S. (author), Choi, J.W. (author), Lee, T.J. (author), Kim, K.Y. (author)Large-magnitude fluid-injection induced seismic events are a potential risk for geothermal energy developments worldwide. One potential risk mitigation measure is the application of cyclic injection schemes. After validation at small (laboratory) and meso (mine) scale, the concept has now been applied for the first time at field scale at the...article 2019
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Tinga, A.M. (author), Jansen, C. (author), van der Smagt, M.J. (author), Nijboer, T.C.W. (author), van Erp, J.B.F. (author)In general, moving sensory stimuli (visual and auditory) can induce illusory sensations of self-motion (i.e. vection) in the direction opposite of the sensory stimulation. The aim of the current study was to examine whether tactile stimulation encircling the waist could induce circular vection (around the body's yaw axis) and to examine whether...article 2018
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Simone, G. (author), di carlo Rasi, D. (author), de Vries, X. (author), Heintges, G.H.L. (author), Meskers, S.C.J. (author), Janssen, R.A.J. (author), Gelinck, G.H. (author)Photovoltaic retinal prostheses show great potential to restore sight in patients suffering from degenerative eye diseases by electrical stimulation of the surviving neurons in the retinal network. Herein, organic photodiodes (OPDs) sensitive to near-infrared (NIR) light are evaluated as photovoltaic pixels for future application in retinal...article 2018
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Schaudien, D. (author), Harleman, J.H. (author), Bouallala, F. (author), Kuper, C.F. (author)Toxicologic pathology plays a crucial role in the identification and interpretation of substance-induced health effects. Histology of lymphoid organs is quite sensitive, although it does not flag every model immunotoxic substance. Subtle interferences of toxic compounds, like transmembrane signaling and cell activation, are often not detectable...bookPart 2018
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- Kong, G. (author), Alais, D. (author), van der Burg, E.D. (author) article 2017
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Lubeck, A.J.A. (author), van Ombergen, A. (author), Ahmad, H. (author), Bos, J.E. (author), Wuyts, F.L. (author), Bronstein, A. (author), Arshad, Q. (author)The objectives of this study were 1) to probe the effects of visual motion adaptation on early visual and V5/MT cortical excitability and 2) to investigate whether changes in cortical excitability following visual motion adaptation are related to the degree of visual dependency, i.e., an overreliance on visual cues compared with vestibular or...article 2017
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van Ombergen, A. (author), Lubeck, A.J. (author), van Rompaey, V. (author), Maes, L.K. (author), Stins, J.F. (author), van de Heyning, P.H. (author), Wuyts, F.L. (author), Bos, J.E. (author)Background: Vestibular patients occasionally report aggravation or triggering of their symptoms by visual stimuli, which is called visual vestibular mismatch (VVM). These patients therefore experience discomfort, disorientation, dizziness and postural unsteadiness. Objective: Firstly, we aimed to get a better insight in the underlying mechanism...article 2016
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Kong, G. (author), Alais, D. (author), van der Burg, E.D. (author)In the present study, we examine how observers search among complex displays. Participants were asked to search for a big red horizontal line among 119 distractor lines of various sizes, orientations and colours, leading to 36 different feature combinations. To understand how people search in such a heterogeneous display, we evolved the search...article 2016
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Koijck, L.A. (author), Toet, A. (author), van Erp, J.B.F. (author)Previous research has shown that odorants consistently evoke associations with textures and their tactile properties like smoothness and roughness. Also, it has been observed that olfaction can modulate tactile perception. We therefore hypothesized that tactile roughness perception may be biased towards the somatosensory connotation of an...article 2015
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Ettwig, J.F. (author), Bronkhorst, A.W. (author)In four experiments, we studied the time course of interference between detection of an oddball orientation target (OT) in an 8-item circular search display, and identification of a letter target (LT) in a central stream of distractor letters. Dual-task performance for different temporal lags between targets was compared to single-task...article 2015
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Berbeé, J.F.P. (author), Boon, M.R. (author), Khedoe, P.P.S.J. (author), Bartelt, A. (author), Schlein, C. (author), Worthmann, A. (author), Kooijman, S. (author), Hoeke, G. (author), Mol, I.M. (author), John, C. (author), Jung, C. (author), Vazirpanah, N. (author), Brouwers, L.P.J. (author), Gordts, P.L.S.M. (author), Esko, J.D. (author), Hiemstra, P.S. (author), Havekes, L.M. (author), Scheja, L. (author), Heeren, J. (author), Rensen, P.C.N. (author)Brown adipose tissue (BAT) combusts high amounts of fatty acids, thereby lowering plasma triglyceride levels and reducing obesity. However, the precise role of BAT in plasma cholesterol metabolism and atherosclerosis development remains unclear. Here we show that BAT activation by b3-adrenergic receptor stimulation protects from atherosclerosis...article 2015
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Gaucher, E. (author), Schoenball, M. (author), Heidbach, O. (author), Zang, A. (author), Fokker, P.A. (author), van Wees, J.D. (author), Kohl, T. (author)In order to reach Europes 2020 and 2050 targets in terms of greenhouse gas emissions, geothermal resources will have to contribute substantially to meeting carbon-free energy needs. However, public opinion may prevent future large-scale application of deep geothermal power plants, because induced seismicity is often perceived as an unsolicited...article 2015
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Schaudien, D. (author), Harleman, H. (author), Bouallala, F. (author), Kuper, C.F. (author)Toxicologic pathology plays a crucial role in the identification and interpretation of substance-induced health effects. Histology of lymphoid organs is quite sensitive, although it does not flag every model immunotoxic substance. Subtle interferences of toxic compounds, like transmembrane signaling and cell activation, are often not detectable...bookPart 2014
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ter Heege, J.H. (author), Zijp, M.H.A.A. (author), de Bruin, G. (author), ten Veen, J.H. (author)Uncertainties in upfront predictions of hydraulic fracturing and gas production of underexplored shale gas targets are important as often large potential resources are deduced based on limited available data. In this paper, uncertainties are quantified by using normal distributions of different input parameters in wellbased models for hydraulic...conference paper 2014