Searched for: subject:"Statistical%5C+model"
(1 - 20 of 64)

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Krone, T. (author), Boessen, R. (author), Bijlsma, S. (author), van Stokkum, R. (author), Clabbers, N.D.S. (author), Pasman, W.J. (author)
Background. N-of-1 designs gain popularity in nutritional research because of the improving technological possibilities, practical applicability and promise of increased accuracy and sensitivity, especially in the field of personalized nutrition. This move asks for a search of applicable statistical methods. Objective. To demonstrate the...
article 2020
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Fransman, W. (author)
[No abstract available]
article 2018
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van Kampen, J. (author), van der Beek, D. (author), Steijn, W. (author), Groeneweg, J. (author), Guldenmund, F. (author)
Background. Organisations spend a considerable amount of time and effort on diagnosing and analysing risks within their organisation. In the area of occupational and process safety, a myriad of employee survey instruments is available. Many studies show that operational processes play an important role in an organisations overall safety. Yet, so...
article 2017
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Havermans, B.M. (author), Boot, C.R.L. (author), Houtman, I.L.D. (author), Brouwers, E.P.M. (author), Anema, J.R. (author), van der Beek, A.J. (author)
BACKGROUND: Health care workers are exposed to psychosocial work factors. Autonomy and social support are psychosocial work factors that are related to stress, and are argued to largely result from the psychosocial safety climate within organisations. This study aimed to assess to what extent the relation between psychosocial safety climate and...
article 2017
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Kuunders, T.J.M. (author), Jacobs, M.A.M. (author), van de Goor, I.A.M. (author), van Bon-Martens, M.J.H. (author), van Oers, H.A.M. (author), Paulussen, T.G.W.M. (author)
Background. Previous evaluation showed insufficient use of a national guideline for integrated local health policy by Regional Health Services (RHS) in the Netherlands. The guideline focuses on five health topics and includes five checklists to support integrated municipal health policies. This study explores the determinants of guideline use by...
article 2017
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van de Ven, H.A. (author), Brouwer, S. (author), Koolhaas, W. (author), Goudswaard, A. (author), de Looze, M.P. (author), Kecklund, G. (author), Almansa, J. (author), Bültmann, U. (author), van der Klink, J.J.L. (author)
In this cross-sectional study associations were examined between eight shift schedule characteristics with shift-specific sleep complaints and need for recovery and generic health and performance measures. It was hypothesized that shift schedule characteristics meeting ergonomic recommendations are associated with better sleep, need for recovery...
article 2016
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Klein Entink, R.H. (author), Bekker, C. (author), Fransman, W.F. (author), Brouwer, D.H. (author)
article 2015
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Vlaming, M.L. (author), van Duijn, E. (author), Dillingh, M.R. (author), Brands, R. (author), Windhorst, A.D. (author), Hendrikse, N.H. (author), Bosgra, S. (author), Burggraaf, J. (author), de Koning, M.C. (author), Fidder, A. (author), Mocking, J.A. (author), Sandman, H. (author), de Ligt, R.A. (author), Fabriek, B.O. (author), Pasman, W.J. (author), Seinen, W. (author), Alves, T. (author), Carrondo, M. (author), Peixoto, C. (author), Peeters, P.A. (author), Vaes, W.H. (author)
Preclinical development of new biological entities (NBEs), such as human protein therapeutics, requires considerable expenditure of time and costs. Poor prediction of pharmacokinetics in humans further reduces net efficiency. In this study, we show for the first time that pharmacokinetic data of NBEs in humans can be successfully obtained early...
article 2015
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van der Voort, M.M. (author), van Wees, R.M.M. (author), Brouwer, S.D. (author), van der Jagt-Deutekom, M.J. (author), Verreault, J. (author)
Forensic analysis of explosions consists of determining the point of origin, the explosive substance involved, and the charge mass. Within the EU fP7 project Hyperion, TNO developed the Inverse Explosion Analysis (TNO-IEA) tool to estïmate the charge mass and point of origin based on observed damage around an explosion. In this paper inverse...
article 2015
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Taylor, S.L. (author), Houben, G.F. (author), Baumert, J.L. (author), Crevel, R.R.W.R. (author), Allen, K.J. (author), Dubois, A.E.J. (author), Knulst, A.C. (author), Remington, B.C. (author), Kruizinga, A.G. (author), Blom, W.M. (author), Brooke-Taylor, S. (author)
article 2015
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Jolani, S. (author), Debray, T.P.A. (author), Koffijberg, H. (author), van Buuren, S. (author), Moons, K.G.M. (author)
Individual participant data meta-analyses (IPD-MA) are increasingly used for developing and validating multivariable (diagnostic or prognostic) risk prediction models. Unfortunately, some predictors or even outcomes may not have been measured in each study and are thus systematically missing in some individual studies of the IPD-MA. As a...
article 2015
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van Buuren, S. (author), Perenboom, R. (author)
There are very few norms to evaluate and monitor the health and functioning of the elderly. This paper proposes a compact spatial representation of 25 health measurements of European citizens older than 50 years. Data from 44,285 unique individuals were obtained from the EU-wide Survey of Health, Ageing and Retirement in Europe(SHARE) data...
article 2014
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Klein Entink, R.H. (author), Remington, B.C. (author), Blom, W.M. (author), Rubingh, C.M. (author), Kruizinga, A.G. (author), Baumert, J.L. (author), Taylor, S.L. (author), Houben, G.F. (author)
For most allergenic foods, limited availability of threshold dose information within the population restricts the advice on action levels of unintended allergenic foods which should trigger advisory labeling on packaged foods.The objective of this paper is to provide guidance for selecting an optimal sample size for threshold dosing studies for...
article 2014
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Zha, Y. (author), Westerhuis, J.A. (author), Muilwijk, B. (author), Overkamp, K.M. (author), Nijmeijer, B.M. (author), Coulier, L. (author), Smilde, A.K. (author), Punt, P.J. (author)
Background: Inhibitors are formed that reduce the fermentation performance of fermenting yeast during the pretreatment process of lignocellulosic biomass. An exometabolomics approach was applied to systematically identify inhibitors in lignocellulosic biomass hydrolysates.Results: We studied the composition and fermentability of 24 different...
article 2014
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Veijgen, N.K. (author), van der Heide, E. (author), Masen, M.A. (author)
Background: The frictional characteristics of skin-object interactions are important when handling objects, in the assessment of perception and comfort of products and materials and in the origins and prevention of skin injuries. In this study, based on statistical methods, a quantitative model is developed that describes the friction behaviour...
article 2013
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Schmettow, M. (author), Vos, W. (author), Schraagen, J.M. (author)
Usability testing is recognized as an effective means to improve the usability of medical devices and prevent harm for patients and users. Effectiveness of problem discovery in usability testing strongly depends on size and representativeness of the sample. We introduce the late control strategy, which is to continuously monitor effectiveness of...
article 2013
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Houben, M.M.J. (author), Kurt, R. (author), Khalid, H. (author), Zoet, P. (author), Bos, J.E. (author), Turan, O. (author)
Within the EU FP7 project SILENV, noise and vibration measurements were carried out on several ships. These objective measures were accompanied by subjective measures recorded through questionnaires. With this, we developed models describing the relationship between the levels of noise and vibration on board ships and subjective ratings on...
conference paper 2012
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van der Meer, J.A. (author), Trap, H.C. (author), Noort, D. (author), van der Schans, M.J. (author), TNO Defensie en Veiligheid (author)
Recently, several methods have been developed to verify exposure to nerve agents. Most of these methods, such as the fluoride reactivation technique and the analysis of inhibited phosphonylated butyrylcholinesterase (BuChE), are based on mass spectrometry. The high specificity of the mass spectrometer might also imply a disadvantage, because the...
article 2010
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Vink, S.R. (author), Mikkers, J. (author), Bouwman, T. (author), Marquart, H. (author), Kroese, E.D. (author), TNO Kwaliteit van Leven (author)
REACH requests the exploration of alternative strategies for hazard identification before resorting to (in vivo) testing. Here, we combined read-across as non-testing strategy with a tiered exposure assessment for the risk characterisation of 1-methoxypropan-2-ol (PGME) as a representative for phase-in substances to be registered under REACH....
article 2010
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Verouden, M.P.H. (author), Westerhuis, J.A. (author), van der Werf, M.J. (author), Smilde, A.K. (author), TNO Kwaliteit van Leven (author)
In metabolomics research a large number of metabolites are measured that reflect the cellular state under the experimental conditions studied. In many occasions the experiments are performed according to an experimental design to make sure that sufficient variation is induced in the metabolite concentrations. However, as metabolomics is a...
article 2009
Searched for: subject:"Statistical%5C+model"
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