Searched for: subject:"Species%5C+Specificity"
(1 - 20 of 54)

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Kienhuis, A.S. (author), van de Poll, M.C.G. (author), Wortelboer, H. (author), van Herwijnen, M. (author), Gottschalk, R. (author), de Jong, C.H.C. (author), Boorsma, A. (author), Paules, R.S. (author), Kleinjans, J.C.S. (author), Stierum, R.H. (author), van Delft, J.H.M. (author), TNO Kwaliteit van Leven (author)
The frequent use of rodent hepatic in vitro systems in pharmacological and toxicological investigations challenges extrapolation of in vitro results to the situation in vivo and interspecies extrapolation from rodents to humans. The toxicogenomics approach may aid in evaluating relevance of these model systems for human risk assessment by direct...
article 2009
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Boesten, R.J. (author), Schuren, F.H.J. (author), de Vos, W.M. (author), TNO Kwaliteit van Leven (author)
A genomic DNA-based microarray was constructed containing over 6000 randomly cloned genomic fragments of approximately 1-2 kb from six mammalian intestinal Bifidobacterium spp. including B. adolescentis, B. animalis, B. bifidum, B. catenulatum, B. longum and B. pseudolongum. This Bifidobacterium Mixed-Species (BMS) microarray was used to...
article 2009
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Prendergast, G.S. (author), Zurn, C.M. (author), Bers, A.V. (author), Head, R.M. (author), Hansson, L.J. (author), Thomason, J.C. (author), TNO Industrie en Techniek (author)
Barnacle cypris larvae respond to many cues when selecting a settlement site. The settlement of over a million larvae on tiles of different textures, orientations and densities of incumbent settlers was measured on the rocky intertidal at Great Cumbrae, Scotland. Half of the tiles were replaced every tide whereas the others simultaneously...
article 2009
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Smit, M.G.D. (author), Bechmann, R.K. (author), Hendriks, A.J. (author), Skadsheim, A. (author), Larsen, B.K. (author), Baussant, T. (author), Bamber, S. (author), Sannei, S. (author), TNO Industrie en Techniek (author)
Biomarkers are widely used to measure environmental impacts on marine species. For many biomarkers, it is not clear how the signal levels relate to effects on the whole organism. This paper shows how species sensitivity distributions (SSDs) can be applied to evaluate multiple biomarker responses in species assemblages. To our knowledge, the...
article 2009
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de Haas, E.M. (author), Kraak, M.H.S. (author), TNO Kwaliteit van Leven (author)
The absence of species in polluted sediments does not necessarily imply exclusion due to toxicity. Other factors, like for instance food availability and oxygen content, could also partly cause their absence. Hence, knowledge of the (combinations of) factors acting on individual organisms is essential in order to understand how populations can...
article 2008
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Beumer, V. (author), van Wirdum, G. (author), Beltman, B. (author), Griffioen, J. (author), Grootjans, A.P. (author), Verhoeven, J.T.A. (author), TNO Bouw en Ondergrond (author)
Dutch water policy aims for more frequent, controlled flooding of river valley floodplains to avoid unwanted flooding elsewhere; in anticipation of increased flooding risks resulting from climate changes. Controlled flooding usually takes place in winter in parts of the valleys which had not been subject to flooding in the last decades. It may...
article 2008
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Oomes, S.J.C.M. (author), van Zuijlen, A.C.M. (author), Hehenkamp, J.O. (author), Witsenboer, H. (author), van der Vossen, J.M.B.M. (author), Brul, S. (author), TNO Kwaliteit van Leven (author)
Spore-forming bacteria can be a problem in the food industry, especially in the canning industry. Spores present in ingredients or present in the processing environment severely challenge the preservation process since their thermal resistance may be very high. We therefore asked the question which bacterial spore formers are found in a typical...
article 2007
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Zvinavashe, E. (author), Murk, A.J. (author), Vervoort, J. (author), Soffers, A.E.M.F. (author), Freidig, A. (author), Rietjens, I.M.C.M. (author), TNO Kwaliteit van Leven (author)
Fifteen experimental literature data sets on the acute toxicity of substituted nitrobenzenes to algae (Scenedesmus obliquus, Chlorella pyrenoidosa, C. vulgaris), daphnids (Daphnia magna, D. carinata), fish (Cyprinus carpio, Poecilia reticulata), protozoa (Tetrahymena pyriformis), bacteria (Phosphobacterium phosphoreum), and yeast (Saccharomyces...
article 2006
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Rennen, M.A.J. (author), Bouwman, T. (author), Wilschut, A. (author), Bessems, J.G.M. (author), de Heer, C. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Due to a lack of route-specific toxicity data, the health risks resulting from occupational exposure are frequently assessed by route-to-route (RtR) extrapolation based on oral toxicity data. Insight into the conditions for and the uncertainties connected with the application of RtR extrapolation has not been clearly described in a systematic...
article 2004
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Sengupta, S. (author), Toh, S.A. (author), Sellers, L.A. (author), Skepper, J.N. (author), Koolwijk, P. (author), Leung, H.W. (author), Yeung, H.W. (author), Wong, R.N.S. (author), Sasisekharan, R. (author), Fan, T.P.D. (author)
Background-Ginseng is a commonly used nutraceutical. Intriguingly, existing literature reports both wound-healing and antitumor effects of ginseng extract through opposing activities on the vascular system. To elucidate this perplexity, we merged a chemical fingerprinting approach with a deconstructional study of the effects of pure molecules...
article 2004
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Krul, C.A.M. (author), Zeilmaker, M.J. (author), Schothorst, R.C. (author), Havenaar, R. (author), TNO Voeding (author)
Human exposure to carcinogenic N-alkylnitrosamines can occur exogenously via food consumption or endogenously by formation of these compounds through nitrosation of amine precursors. Information on the intragastric formation of NDMA from complex mixtures of precursors and inhibitors in humans is not available. In this study the formation of N...
article 2004
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Berry, A. (author), Janssens, D. (author), Hümbelin, M. (author), Jore, J.P.M. (author), Hoste, B. (author), Cleenwerck, I. (author), Vancanneyt, M. (author), Bretzel, W. (author), Mayer, A.F. (author), Lopez-Ulibarri, R. (author), Shanmugam, B. (author), Swings, J. (author), Pasamontes, L. (author)
A comprehensive taxonomic re-evaluation was performed on the marine, zeaxanthin-producing bacterium formerly classified as [Flavobacterium] sp. strain R-1512 (ATCC 21588). This strain, together with two other previously described marine isolates, [Flavobacterium] strain R-1506 and Paracoccus sp. strain MBIC 3966, were found to comprise a new...
article 2003
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't Hart, B.A. (author), Vogels, J.T.W.E. (author), Spijksma, G. (author), Brok, H.P.M. (author), Polman, C. (author), van der Greef, J. (author), Primatencentrum TNO (author)
Proton nuclear magnetic resonance (1H-NMR) spectroscopy in combination with pattern recognition techniques were used to investigate the composition of organic compounds in urines from patients with multiple sclerosis (MS), patients with other neurological diseases (OND) and healthy controls (H). Using a valid animal model of MS, namely the...
article 2003
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Fairlamb, I.J.S. (author), Dickinson, J.M. (author), O'Connor, R. (author), Cohen, L.H. (author), van Thiel, C.F. (author)
The synthesis and first antimicrobial evaluation of farnesyl diphosphate mimetics are described. Several analogues (10, 12, 13, and 20) are inhibitors of Candida albicans, Shizosaccharomyces pombe, and Saccharomyces cerevisiae. The activities of analogues 10, 12, and 13, which contain a ω-phenyl moiety and a diphosphate isostere, are not...
article 2003
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Bos, P.M.J. (author), Busschers, M. (author), Arts, J.H.E. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
Within the framework of risk assessment of existing substances in the EC the irritating properties on the respiratory tract should be considered. Since no standardized test is available it was studied whether the Alarie test could be used for this purpose, as proposed by the Technical Guidance Document for new and existing substances. The...
article 2002
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Cappaert, N.L.M. (author), Klis, S.F.L. (author), Muijser, H. (author), Kulig, B.M. (author), Ravensberg, L.C. (author), Smoorenburg, G.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The present study was designed to compare the ototoxic effects of volatile ethyl benzene in guinea pigs and rats. Rats showed deteriorated auditory thresholds in the mid-frequency range, based on electrocochleography, after 550-ppm ethyl benzene (8 h/day, 5 days). Outer hair cell (OHC) loss was found in the corresponding cochlear regions. In...
article 2002
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Seegers, J.F.M.L. (author)
Evidence is accumulating that lactobacilli influence the immune response in a strain-dependent manner. This immunomodulatory capacity is important for the development of the immune response, and also identifies Lactobacillus as a potent oral vaccine carrier. Most of our current knowledge of the use of lactobacilli for vaccination purposes has...
article 2002
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Wolken, W.A.M. (author), Tramper, J. (author), van der Werf, M.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Spores, although often considered metabolically inert, catalyze a variety of reactions. The use of spores instead of mycelium for bioconversions has several advantages. In this paper, we describe the difference in susceptibility of mycelium and spores against toxic substrates and products. A higher resistance of spores toward the toxic effects...
article 2002
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Dybing, E. (author), Doe, J. (author), Groten, J. (author), Kleiner, J. (author), O'Brien, J. (author), Renwick, A.G. (author), Schlatter, J. (author), Steinberg, P. (author), Tritscher, A. (author), Walker, R. (author), Younes, M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Hazard characterisation of low molecular weight chemicals in food and diet generally use a no-observed-adverse-effect level (NOAEL) or a benchmark dose as the starting point. For hazards that are considered not to have thresholds for their mode of action, low-dose extrapolation and other modelling approaches may be applied. The default position...
article 2002
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TNO Preventie en Gezondheid (author), Janssen, R. (author), Kruisselbrink, A. (author), Hoogteijling, L. (author), Lamb, J.R. (author), Young, D.B. (author), Thole, J.E.R. (author)
The potential for development of mycobacteria as T helper type 1 (Th1) vaccines capable of induction of Th1 responses to recombinant antigens was explored in a model system based on an immunodominant peptide from house dust mite. Different recombinant mycobacterial preparations were compared for their ability to induce a Th1 response to the...
article 2001
Searched for: subject:"Species%5C+Specificity"
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