A novel safety assessment strategy applied to non-selective extracts

A main challenge in food safety research is to demonstrate that processing of foodstuffs does not lead to the formation of substances for which the safety upon consumption might be questioned. This is especially so since food is a complex matrix in which the analytical detection of substances, and consequent risk assessment thereof, is difficult...

Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling

The use of laboratory animals for toxicity testing in chemical safety assessment meets increasing ethical, economic and legislative constraints. The development, validation and application of reliable alternatives for in vivo toxicity testing are therefore urgently needed. In order to use toxicity data obtained from in vitro assays for risk...

Prediction of in vivo developmental toxicity of all‑trans‑retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling

Bioavailability and biodegradation of nonylphenol in sediment determined with chemical and bioanalysis

The surfactant nonylphenol (NP) is an endocrine-disrupting compound that is widely spread throughout the environment. Although environmental risk assessments are based on total NP concentrations, only the bioavailable fraction posses an environmental risk. The present study describes the bioavailability and biodegradability of NP over time in...

Sensing dissolved sediment porewater concentrations of persistent and bioaccumulative poolutants using disposable solid-phase microextraction fibers

Polymer coated glass fibers were applied as disposable samplers to measure dissolved concentrations of persistent and bioaccumulative pollutants (PBPs) in sediment porewater. The method is called matrix solid-phase microextraction (matrix-SPME), because it utilizes the entire sediment matrix as a reservoir for an equilibrium extraction: A glass...

Polyacrylate-coated SPME fibers as a tool to simulate body residues and target concentrations of complex organic mixtures for estiomation of baseline toxicity

The acute toxicity of narcotic organic chemical mixtures is related to the total molar concentration within organisms. In this study, the use of polyacrylate SPME fibers is investigated for the purpose of biomimetic extractions, a procedure used to simulate bioconcentration and to estimate total concentrations in aquatic organisms. Experimental...