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Hogervorst, M.A. (author), Brouwer, A.M. (author), van Erp, J.B.F. (author)While studies exist that compare different physiological variables with respect to their association with mental workload, it is still largely unclear which variables supply the best information about momentary workload of an individual and what is the benefit of combining them. We investigated workload using the n-back task, controlling for...article 2014
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Schrieks, I.C. (author), Stafleu, A. (author), Kallen, V.L. (author), Grootjen, M. (author), Witkamp, R.F. (author), Hendriks, H.F.J. (author)Background: The pre-drinking mood state has been indicated to be an important factor in the mood effects of alcohol. However, for moderate alcohol consumption there are no controlled studies showing this association. Also, the mood effects of consuming alcohol combined with food are largely unknown. The aim of this study was to investigate the...article 2014
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van der Veen, J.W. (author), Soeteman-Hernández, L.G. (author), Ezendam, J. (author), Stierum, R. (author), Kuper, F.C. (author), van Loveren, H. (author)Allergic contact dermatitis (ACD) is a hypersensitivity immune response induced by small protein-reactive chemicals. Currently, the murine local lymph node assay (LLNA) provides hazard identification and quantitative estimation of sensitizing potency. Given the complexity of ACD, a single alternative method cannot replace the LLNA, but it is...article 2014
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Brouwer, A.M. (author), Hogervorst, M.A. (author)We here introduce a new experimental paradigm to induce mental stress in a quick and easy way while adhering to ethical standards and controlling for potential confounds resulting from sensory input and body movements. In our Sing-a-Song Stress Test, participants are presented with neutral messages on a screen, interleaved with 1-min time...article 2014
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Raaijmakers, S.F. (author), Steel, F.W. (author), de Goede, M. (author), van Wouwe, N.C. (author), van Erp, J.B.F. (author), Brouwer, A.M. (author)High heart rate variability (HRV) and low skin conductance level (SCL) have been associated with low levels of stress. Biofeedback - providing an individual with online information about his or her own physiological state – may help to change these signals in the desired direction and therewith improve an individual’s physical or mental...conference paper 2013
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van Kuilenburg, J. (author), Masen, M.A. (author), van der Heide, E. (author)The friction behaviour of the human fingerpad as a function of asperity geometry was investigated experimentally. Surface textures consisting of evenly distributed spherically tipped asperities were used for in vivo testing. Using analytical expressions, a multi-scale model was developed to explain the observed friction behaviour as a function...article 2013
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Veijgen, N.K. (author), Masen, M.A. (author), van der Heide, E. (author)The human skin is constantly in interaction with materials and products. Therefore, skin friction is relevant to all people. In the literature, the frictional properties of the skin have been linked to a large variety of variables, like age, gender and hydration. The present study compares the data of 450 skin friction measurements with the skin...article 2013
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Abdulahad, D.A. (author), Westra, J. (author), Reefman, E. (author), Zuidersma, E. (author), Bijzet, J. (author), Limburg, P.C. (author), Kallenberg, C.G.M. (author), Bijl, M. (author)Photosensitivity is characteristic of systemic lupus erythematosus (SLE). Upon ultraviolet B (UVB) exposure, patients develop inflammatory skin lesions in the vicinity of sunburn cells (SBCs). High mobility group box 1 (HMGB1) is released from apoptotic and activated cells and exerts inflammatory actions through ligation to its receptors....article 2013
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Daanen, H.A.M. (author), van Ling, S. (author), Tan, T.K. (author)Background: It has been shown that endurance performance after one night of sleep deprivation is not compromised despite the feeling of fatigue and that, in contrast, performance in the heat deteriorates even though people may feel good. However, it is essentially unknown how the estimation of performance capabilities relate to actual...article 2013
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Blatchford, P. (author), Ansell, J. (author), de Godoy, M.R.C. (author), Fahey, G. (author), Garcia-Mazcorro, J.F. (author), Gibson, G.R. (author), Goh, Y.J. (author), Hotchkiss, A.T. (author), Hutkins, R. (author), LaCroix, C. (author), Rastall, R.A. (author), Reimer, R.A. (author), Schoterman, M. (author), Van Sinderen, D. (author), Venema, K. (author), Whelan, K. (author)In October 2012, a group of scientists met at the 10th Meeting of the International Scientific Association of Probiotics and Prebiotics (ISAPP) in Cork, Ireland to discuss issues surrounding prebiotics and their development. This article summarises outputs from the meeting. Various prebiotic definitions were discussed and how the concept has...article 2013
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Teunis, M. (author), Corsini, E. (author), Smits, M. (author), Madsen, C.B. (author), Eltze, T. (author), Ezendam, J. (author), Galbiati, V. (author), Gremmer, E. (author), Krul, C.A.M. (author), Landin, A. (author), Landsiedel, R. (author), Pieters, R. (author), Rasmussen, T.F. (author), Reinders, J. (author), Roggen, E. (author), Spiekstra, S. (author), Gibbs, S. (author)At present, the identification of potentially sensitizing chemicals is carried out using animal models. However, it is very important from ethical, safety and economic point of view to have biological markers to discriminate allergy and irritation events, and to be able to classify sensitizers according to their potency, without the use of...article 2013
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Arrandale, V. (author), Meijster, T. (author), Pronk, A. (author), Doekes, G. (author), Redlich, C.A. (author), Holness, D.L. (author), Heederik, D. (author)Purpose: Despite the importance of skin exposure, studies of skin symptoms in relation to exposure and respiratory symptoms are rare. The goals of this study were to describe exposure-response relationships for skin symptoms, and to investigate associations between skin and respiratory symptoms in bakery and auto body shop workers. Methods: Data...article 2013
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Hogervorst, M.A. (author), Brouwer, A.M. (author), Vos, W.K. (author)We examined to what extent we can distinguish between ‘real-life’ stressed and relaxed participants on the basis of heart rate (HR), heart rate variability (HRV) and skin conductance level (SCL) as measured during rest. Physiological and subjective measures were compared between individuals that were to undergo eye laser surgery and a control...conference paper 2013
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Brouwer, A.M. (author), van Schaik, M.G. (author), van Erp, J.B.F. (author), Korteling, J.E. (author)Low neuroticism and high extraversion seem to be predictors for people performing well during and after extremely stressful circumstances. Here we investigate whether these personality factors are linked to stress sensitivity. Stress was induced through negative feedback on gaming performance and stress sensitivity was determined as the...conference paper 2013
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Unraveling toxicological mechanisms and predicting toxicity classes with gene dysregulation networksPronk, T.E. (author), van Someren, P. (author), Stierum, R.H. (author), Ezendam, J. (author), Pennings, J.L.A. (author)The use of genes for distinguishing classes of toxicity has become well established. In this paper we combine the reconstruction of a gene dysregulation network (GDN) with a classifier to assign unseen compounds to their appropriate class. Gene pairs in the GDN are dysregulated in the sense that they are linked by a common expression pattern in...article 2013
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van der Heide, E. (author), Zeng, X. (author), Masen, M.A. (author)The application of tribological knowledge is not just restricted to optimizing mechanical and chemical engineering problems. In fact, effective solutions to friction and wear related questions can be found in our everyday life. An important part is related to skin tribology, as the human skin is frequently one of the interacting surfaces in...article 2013
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Brouwer, A.M. (author), van Wouwe, N.C. (author), Mühl, C. (author), van Erp, J.B.F. (author), Toet, A. (author)Most studies on physiological effects of emotion-inducing images and sounds examine stimulus locked variables reflecting a state of at most a few seconds. We here aimed to induce longer lasting emotional states using blocks of repetitive visual, auditory, and bimodal stimuli corresponding to specific valence and arousal levels. The duration of...article 2013
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van Kuilenburg, J. (author), Masen, M.A. (author), Groenendijk, M.N.W. (author), Bana, V. (author), van der Heide, E. (author)The main obstacle to calculate the 'feel' of a product from its surface properties is the ill-defined surface topography that is encountered after the most surface finishing processes. In this work this obstacle was avoided by producing well-defined surface topographies by laser texturing. The friction of textures having surface features with...article 2012
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Reus, A.A. (author), Usta, M. (author), Kenny, J.D. (author), Clements, P.J. (author), Pruimboom-Brees, I. (author), Aylott, M. (author), Lynch, A.M. (author), Krul, C.A.M. (author)An in vivo photomicronucleus test (MNT) using rat skin, the target organ for photoirritancy and carcinogenicity, was recently described. The assay was evaluated using fluoroquinolone (FQ) antibiotics with varying degrees of phototoxic potency (i.e. sparflocacin [SPFX], lomefloxacin [LOFX], ciprofloxacin [CIFX], levofloxacin [LEFX], gemifloxacin ...article 2012
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van Kuilenburg, J. (author), Masen, M.A. (author), van der Heide, E. (author)In this work, analytical models available from contact mechanics theory having a proven record in mechanical engineering were used to develop a model predicting the friction behavior of human skin. A multi-scale contact model was developed in which the contact parameters are calculated at three levels, each level characterized by its elastic...conference paper 2012