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Joosen, M.J.A. (author), van den Berg, R.M. (author), de Jong, A.L. (author), van der Schans, M.J. (author), Noort, D. (author), Langenberg, J.P. (author)The main goal of the present study was to obtain insight into depot formation and penetration following percutaneous VX poisoning, in order to identify an appropriate decontamination window that can enhance or support medical countermeasures. The study was executed in two phases, using the hairless guinea pig as an animal model. In the first...article 2017
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Kasiotis, K.M. (author), Tsakirakis, A.N. (author), Richard Glass, C. (author), Charistou, A.N. (author), Anastassiadou, P. (author), Gerritsen-Ebben, R. (author), Machera, K. (author)A dislodgeable foliar residue study was conducted in greenhouse pepper and tomato on the island of Crete, Greece, following the spray application of an SC insecticide (with active substance (a.s.) tebufenozide) and an EC fungicide (a.s. bupirimate). Furthermore, for the assessment of worker exposure to pesticides – as a result of re-entering the...article 2017
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Williams, F.M. (author), Rothe, H. (author), Barrett, G. (author), Chiodini, A. (author), Whyte, J. (author), Cronin, M.T.D. (author), Monteiro-Riviere, N.A. (author), Plautz, J. (author), Roper, C. (author), Westerhout, J. (author), Yang, C. (author), Guy, R.H. (author)Threshold of Toxicological Concern (TTC) aids assessment of human health risks from exposure to low levels of chemicals when toxicity data are limited. The objective here was to explore the potential refinement of exposure for applying the oral TTC to chemicals found in cosmetic products, for which there are limited dermal absorption data. A...article 2016
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Brouwer, D.H. (author), Spaan, S. (author), Roff, M. (author), Sleeuwenhoek, A. (author), Tuinman, I. (author), Goede, H. (author), van Duuren-Stuurman, B. (author), Filon, F.L. (author), Bello, D. (author), Cherrie, J.W. (author)Over the past decade, the primary focus of nanotoxicology and nanoenvironmental health and safety efforts has been largely on inhalation exposure to engineered nanomaterials, at the production stage, and much less on considering risks along the life cycle of nano-enabled products. Dermal exposure to nanomaterials and its health impact has been...article 2016
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Larese Filon, F. (author), Bello, D. (author), Cherrie, J.W. (author), Sleeuwenhoek, A. (author), Spaan, S. (author), Brouwer, D.H. (author)The paper reviews and critically assesses the evidence on the relevance of various skin uptake pathways for engineered nanoparticles, nano-objects, their agglomerates and aggregates (NOAA). It focuses especially in occupational settings, in the context of nanotoxicology, risk assessment, occupational medicine, medical/epidemiological...article 2016
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Bogerd, C.P. (author), Aerts, J.M. (author), Annaheim, S. (author), Bröde, P. (author), de Bruyne, G. (author), Flouris, A.D. (author), Kuklane, K. (author), Sotto Mayor, T. (author), Rossi, R.M. (author)The thermal effects related to wearing headgear are complex and different studies have investigated single parts of this topic. This review aims at summarizing the different findings to give a complete overview on this topic as well as to suggest new perspectives. Headgear increases head insulation and therefore is mainly problematic under warm...article 2015
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Nohynek, G.J. (author), Skare, J.A. (author), Meuling, W.J.A. (author), Wehmeyer, K.R. (author), de Bie, A.T.H.J. (author), Vaes, W.H.J. (author), Dufour, E.K. (author), Fautz, R. (author), Steiling, W. (author), Bramante, M. (author), Toutain, H. (author)Systemic exposure was measured in humans after hair dyeing with oxidative hair dyes containing 2.0% (A) or 1.0% (B) [14C]-p-phenylenediamine (PPD). Hair was dyed, rinsed, dried, clipped and shaved; blood and urine samples were collected for 48 hours after application. [14C] was measured in all materials, rinsing water, hair, plasma, urine and...article 2015
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Differences in injury risk and characteristics between Dutch amateur and professional soccer playersvan Beijsterveldt, A.M.C. (author), Stubbe, J.H. (author), Schmikli, S.L. (author), van de Port, I.G.L. (author), Backx, F.J.G. (author)Objectives: To compare the incidence and characteristics of injuries between Dutch amateur and professional male soccer players during one entire competition season. Design: A prospective two-cohort design. Methods: During the 2009-2010 season, 456 Dutch male amateur soccer players and 217 professional players were prospectively followed....article 2015
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Brouwer, A.M. (author), van Schaik, M.G. (author), Korteling, J.E. (author), van Erp, J.B.F. (author), Toet, A. (author)High extraversion and conscientiousness and low neuroticism predict successful performance during and after stressful conditions. We investigated whether these personality factors are linked to stress sensitivity and to baseline physiology. Stress was induced through negative feedback on gaming performance. Stress sensitivity was determined as...article 2015
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Physiological correlates of mental effort as manipulated through lane width during simulated drivingBrouwer, A.M. (author), Dijksterhuis, C. (author), van Erp, J.B.F. (author)Previous studies suggest that physiological effects of mental effort as manipulated trough cognitive task difficulty differ from effects of mental effort as manipulated trough a visuomotor task such as lane keeping in simulated driving. Most notably, heart rate increases with mental effort in the former but not in the latter task. EEG seems to...conference paper 2015
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- Schrieks, I.C. (author), Stafleu, A. (author), Kallen, V.L. (author), Grootjen, M. (author), Witkamp, R.F. (author), Hendriks, H.F.J. (author) article 2015
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Zhang, S. (author), Rodriguez Urribarri, A. (author), Morales Hurtado, M. (author), Zeng, X. (author), van der Heide, E. (author)To control tactile friction, that is the friction between fingertip and counter-body, the role of surface texture is required to be unveiled and defined. In this research, an experimental approach is used based on measuring tactile friction for directional texture (grooved channel) with varying depths. For a reference surface, in this current...article 2015
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Morales-Hurtado, M. (author), Zeng, X. (author), Gonzalez-Rodriguez, P. (author), ten Elshof, J.E. (author), van der Heide, E. (author)Research on human skin interactions with healthcare and lifestyle products is a topic continuously attracting scientific studies over the past years. It is possible to evaluate skin mechanical properties based on human or animal experimentation, yet in addition to possible ethical issues, these samples are hard to obtain, expensive and give rise...article 2015
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Hulst, A.G. (author), Verstappen, D.R.W. (author), van der Riet-van Oeveren, D. (author), Vermeulen, N.P.E. (author), Noort, D. (author)In the current paper we show that exposure of human callus to isocyanates leads to covalent modifications within keratin proteins. Mass spectrometric analyses of pronase digests of keratin isolated from exposed callus show that both mono- and di-adducts (for di-isocyanates) are predominantly formed on the ε-amino group of lysine. In addition,...article 2015
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Teunis, M.A.T. (author), Spiekstra, S.W. (author), Smits, M. (author), Adriaens, E. (author), Eltze, T. (author), Galbiati, V. (author), Krul, C.A.M. (author), Landsiedel, R. (author), Pieters, R. (author), Reinders, J. (author), Roggen, E. (author), Corsini, E. (author), Gibbs, S. (author)This study describes the international ring trial of the epidermal-equivalent (EE) sensitizer potency assay. This assay does not distinguish a sensitizer from a non-sensitizer, but may classify known skin sensitizers according to their potency. It assesses the chemical concentration resulting in 50% cytotoxicity (EE-EC50) or the 2-fold increase...article 2014
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Levels, K. (author), de Koning, J. (author), Broekhuijzen, I. (author), Zwaan, T. (author), Foster, C. (author), Daanen, H. (author)The goal of this study was to investigate the effects of different durations of skin temperature manipulation on pacing patterns and performance during a 15-km cycling time trial. Nineteen well-trained men completed three 15-km cycling time trials in 18°C and 50% relative humidity with 4.5-km (short-heat), 9.0-km (long-heat) or without (control)...article 2014
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Schreuder, E. (author), Hoeksma, M.R. (author), Smeets, M.A.M. (author), Semin, G.R. (author)This study reports an examination of the internal clock model, according to which subjective time duration is influenced by attention and arousal state. In a time production task, we examine the hypothesis that an arousing odor and an upright body posture affect perceived duration. The experimental task was performed while participants were...article 2014
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Teunissen, L.P.J. (author), Wang, L.C. (author), Chou, S.N. (author), Huang, C. (author), Jou, G.T. (author), Daanen, H.A.M. (author)Firemen often suffer from heat strain. This study investigated two chest cooling systems for use under a firefighting suit. In nine male subjects, a vest with water soaked cooling pads and a vest with water perfused tubes were compared to a control condition. Subjects performed 30 min walking and 10 min recovery in hot conditions, while...article 2014
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Brouwer, A.M. (author), Hogervorst, M.A. (author), Holewijn, M. (author), van Erp, J.B.F. (author)Learning to master a task is expected to be accompanied by a decrease in effort during task execution. We examine the possibility to monitor learning using physiological measures that have been reported to reflect effort or workload. Thirty-five participants performed different difficulty levels of the n-back task while a range of physiological...article 2014
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Levels, K. (author), de Koning, J.J. (author), Mol, E. (author), Foster, C. (author), Daanen, H.A.M. (author)This study examined the effect of active pre-warming on speed and quality of performance during simulated firefighting exercise. Twelve male firefighters performed two trials in counterbalanced order. They were either pre-warmed by 20-min cycling at 1.5 Watt kg-1 body mass (WARM) or remained thermoneutral (CON) prior to a simulated firefighting...article 2014