Med. Biological Laboratory-TNO, Immunol./Med. Microbiol. Dept. Instituut voor verouderings- en vaatziekten onderzoek TNO Medisch Biologisch Laboratorium TNO (author), Gerritse, K. (author), de Knijff, P. (author), Ierssel, G.V. (author), Havekes, L.M. (author), Frants, R.R. (author), Schellekens, M.M. (author), Zegers, N.D. (author), Claassen, E. (author), Boersma, W.J.A. (author) A specific anti-apoE2(Arg158→Cys) monoclonal antibody was raised by means of immunization of mice with a variant specific synthetic peptide. The peptide sequences used were homologous to apolipoprotein E of human and mouse. Consequently, the mouse immune system was tolerant to most of the selected sequences. Immunization with only one of...
article 1992