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de Bruin-Hoegée, J.M. (author), Lamriti, L. (author), Langenberg, J.P. (author), Olivier, R.C.M. (author), Chau, L.F. (author), van der Schans, M.J. (author), Noort, D. (author), van Asten, A.C. (author)
The continuing threats of military conflicts and terrorism may involve the misuse of chemical weapons. The present study aims to use environmental samples to find evidence of the release of such agents at an incident scene. A novel approach was developed for identifying protein adducts in plants. Basil (Ocimum basilicum), bay laurel leaf (Laurus...
article 2023
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Smit, R. (author), van der Ploeg, C. (author), Teerhuis, A. (author), Silvas, E. (author)
The urban environment is amongst the most difficult domains for autonomous vehicles. The vehicle must be able to plan a safe route on challenging road layouts, in the presence of various dynamic traffic participants such as vehicles, cyclists and pedestrians and in various environmental conditions. The challenge remains to have motion planners...
conference paper 2022
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Mokkink, L.B. (author), de Vet, H. (author), Diemeer, S. (author), Eekhout, I. (author)
Simulation studies were performed to investigate for which conditions of sample size of patients (n) and number of repeated measurements (k) (e.g., raters) the optimal (i.e., balance between precise and efficient) estimations of intraclass correlation coefficients (ICCs) and standard error of measurements (SEMs) can be achieved. Subsequently, we...
article 2022
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Suchowerska, A.K. (author), Stokman, G. (author), Palmer, J.T. (author), Coghlan, P.A. (author), Pieterman, E.J. (author), Keijzer, N. (author), Lambert, G. (author), Chemello, K. (author), Jaafar, A.K. (author), Parmar, J. (author), Yan, L. (author), Tong, Y. (author), Mu, L. (author), Princen, H.M.G. (author), Bonnar, J. (author), Evison, B.J. (author)
Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibits the clearance of low-density lipoprotein (LDL) cholesterol (LDL-C) from plasma by directly binding with the LDL receptor (LDLR) and sending the receptor for lysosomal degradation. As the interaction promotes elevated plasma LDL-C levels, and therefore a predisposition to...
article 2022
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Terluin, B. (author), Eekhout, I. (author), Terwee, C.B. (author)
Objectives: The anchor-based minimal important change (MIC), based on the receiver operating characteristic (ROC) analysis or predictive modeling, is biased by the proportion of improved patients. The adjusted MIC, published in 2017, adjusts the predictive MIC for this bias but does not take the reliability of the transition ratings (i.e., the...
article 2022
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Austin, P.C. (author), van Buuren, S. (author)
Background: Multiple imputation is frequently used to address missing data when conducting statistical analyses. There is a paucity of research into the performance of multiple imputation when the prevalence of missing data is very high. Our objective was to assess the performance of multiple imputation when estimating a logistic regression...
article 2022
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Brink, H.M.T. (author), Hitzenberger, R. (author), Keuken, M. (author)
Elemental Carbon (EC) is a good indicator for aerosol air quality and a main component in global warming; therefore data on its historic concentration would be highly valuable for an assessment of historic levels. There were already major sources of EC in Europe in the early 20th century, but the component has only been measured since the late...
article 2021
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Figueiredo, D.M. (author), Krop, E.J.M. (author), Duyzer, J. (author), Gerritsen-Ebben, R.M. (author), Gooijer, Y.M. (author), Holterman, H.J. (author), Huss, A. (author), Jacobs, C.M.J. (author), Kivits, C.M. (author), Kruijne, R. (author), Mol, H.J.G.J. (author), Oerlemans, A. (author), Sauer, P.J.J. (author), Scheepers, P.T.J. (author), van de Zande, J.C. (author), van den Berg, E. (author), Wenneker, M. (author), Vermeulen, R.C.H. (author)
Background: Application of pesticides in the vicinity of homes has caused concern regarding possible health effects in residents living nearby. However, the high spatiotemporal variation of pesticide levels and lack of knowledge regarding the contribution of exposure routes greatly complicates exposure assessment approaches. Objective: The...
article 2021
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Butler, F. (author), Lucas Luijckx, N.B. (author), Marvin, H.J.P. (author), Bouzembrak, Y. (author), Mojtahed, V. (author)
Food fraud is of high concern to the food industry. A multitude of analytical technologies exist to detect fraud. However, this testing is often expensive. Available databases detailing fraud occurrences were systematically examined to determine how frequently analytical testing triggered fraud detection. A conceptual framework was developed for...
article 2021
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Hemme, M. (author), Fidder, A. (author), van der Riet-van Oeveren, D. (author), van der Schans, M.J. (author), Noort, D. (author)
The primary aim of this study was to identify biomarkers of exposure to some so-called Schedule 1 sulfur mustard (HD) analogues, in order to facilitate and expedite their retrospective analysis in case of alleged use of such compounds. Since these HD analogues can be regarded as model compounds for possible impurities of HD formed during...
article 2021
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Keyvani Janbahan, A. (author), van der Veen, G. (author), Tamer, M.S. (author), Sadeghian Marnani, H. (author), Goosen, H. (author), van Keulen, F. (author)
The real-time and accurate measurement of tip-sample interaction forces in Tapping Mode Atomic Force Microscopy (TM-AFM) is a remaining challenge. This obstruction fundamentally stems from the causality of the physical systems. Since the input of the dynamic systems propagates to the output with some delay, and multiple different inputs can...
article 2020
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van Dam, T.J. (author), Neumann, N.M.P. (author), Phillipson, F. (author), van den Berg, H. (author)
article 2020
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Krone, T. (author), Boessen, R. (author), Bijlsma, S. (author), van Stokkum, R. (author), Clabbers, N.D.S. (author), Pasman, W.J. (author)
Background. N-of-1 designs gain popularity in nutritional research because of the improving technological possibilities, practical applicability and promise of increased accuracy and sensitivity, especially in the field of personalized nutrition. This move asks for a search of applicable statistical methods. Objective. To demonstrate the...
article 2020
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Ramaswamy, K.R. (author), Fonseca, R.M. (author), Leeuwenburgh, O. (author), Siraj, M.M. (author), van den Hof, P.M.J. (author)
We are concerned with the efficiency of stochastic gradient estimation methods for large-scale nonlinear optimization in the presence of uncertainty. These methods aim to estimate an approximate gradient from a limited number of random input vector samples and corresponding objective function values. Ensemble methods usually employ Gaussian...
article 2020
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Peters, E. (author), Ostendorf, M. (author), Bösch, T. (author), Seyler, A. (author), Schönhardt, A. (author), Schreier, S.F. (author), Henzing, J.S. (author), Wittrock, F. (author), Richter, A. (author), Vrekoussis, M. (author), Burrows, J.P. (author)
A novel imaging-DOAS (differential optical absorption spectroscopy) instrument IMPACT (Imaging MaPper for AtmospheriC observaTions) is presented combining full-azimuthal pointing (360◦) with a large vertical coverage (∼41◦). Complete panoramic scans are acquired at a temporal resolution of ∼15min, enabling the retrieval of NO2 vertical profiles...
article 2019
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van Neer, P.L.M.J. (author), van Riel, M.C.J.M. (author), van Es, M.H. (author), Shoeibi Omrani, P.S. (author), Hatakeyama, K. (author), Mohtashami, A. (author), Quesson, B.A.J. (author), van der Lans, M.J. (author), Sadeghian Marnani, H. (author)
other 2019
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Žemaitis, A. (author), Mikšys, J. (author), Gaidys, M. (author), Gecys, P. (author), Gedvilas, M. (author)
Bio-inspired surfaces are able to decrease friction with fluids and gases. The most recognizable are shark-skin-like riblet surface structures. Such bio-inspired surfaces can be formed by the laser ablation technique. In this work, bio-inspired riblet surfaces with grooves were formed using picosecond ultraviolet laser ablation on pre-heated...
article 2019
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Papadopoulos, N. (author), Steudel, S. (author), Kronemeijer, A.J. (author), Ameys, M. (author), Myny, K. (author)
conference paper 2019
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Zillien, C. (author), van Loon, C. (author), Gulpen, M. (author), Tipatet, K. (author), Hanssen, B. (author), Beeltje, H. (author), Roex, E. (author), Oldenkamp, R. (author), Posthuma, L. (author), Ragas, A.M.J. (author)
Over the past decade, the health care sector has becomeincreasingly aware of the impact of pharmaceutical emissions to the environment. Yet, it remains unclearwhich compounds are the most relevant to address and at what point emission control is most effective. This study presents a modelling framework to prioritize pharmaceuticals based on...
article 2019
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Kartaram, S. (author), Mensink, M. (author), Teunis, M. (author), Schoen, E. (author), Witte, G. (author), Janssen Duijghuijsen, L. (author), Verschuren, M. (author), Mohrmann, K. (author), M'Rabet, L. (author), Knipping, K. (author), Wittink, H. (author), van Helvoort, A. (author), Garssen, J. (author), Witkamp, R. (author), Pieters, R. (author), van Norren, K. (author)
Background & aims: Plasma citrulline concentration is considered to be a marker for enterocyte metabolic mass and to reflect its reduction as may occur during intestinal dysfunction. Strenuous exercise can act as a stressor to induce small intestinal injury. Our previous studies suggest that this comprises the intestinal ability to produce...
article 2019
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