Searched for: subject:"Salmonella%5C+typhimurium"
(1 - 19 of 19)
document
End, C. (author), Bikker, F.J. (author), Renner, M. (author), Bergmann, G. (author), Lyer, S. (author), Blaich, S. (author), Hudler, M. (author), Helmke, B. (author), Gassler, N. (author), Autschbach, F. (author), Ligtenberg, A.J.M. (author), Benner, A. (author), Holmskov, U. (author), Schirmacher, P. (author), Nieuw Amerongen, A.V. (author), Rosenstiel, P. (author), Sina, C. (author), Franke, A. (author), Hafner, M. (author), Kioschis, P. (author), Schreiber, S. (author), Poustka, A. (author), Mollenhauer, J. (author)
Deleted in malignant brain tumors 1 (DMBT1) is a secreted glycoprotein displaying a broad bacterial-binding spectrum. Recent functional and genetic studies linked DMBT1 to the suppression of LPS-induced TLR4-mediated NF-kappaB activation and to the pathogenesis of Crohn's disease. Here, we aimed at unraveling the molecular basis of its function...
article 2009
document
Ponstein-Simarro Doorten, A.Y. (author), van de Wiel, J.A.G. (author), Jonker, D. (author), TNO Kwaliteit van Leven (author)
Tensguard™ is a milk protein hydrolysate containing the lactotripeptide IPP. It is derived from cow's milk, which is present in the human diet and has a safe history of consumption. The final Tensguard™ product, a supplement or a functional food ingredient, is intended for use by people who want to follow a healthy diet and lifestyle in order to...
article 2009
document
Kieboom, J. (author), Abee, T. (author), TNO Defensie en Veiligheid (author)
Salmonella enterica serovar Typhimurium does not survive a pH 2.5 acid challenge under conditions similar to those used for Escherichia coli (J. W. Foster, Nat. Rev. Microbiol. 2:898-907, 2004). Here, we provide evidence that S. enterica serovar Typhimurium can display arginine-dependent acid resistance (AM) provided the cells are grown under...
article 2006
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Fairlamb, I.J.S. (author), Dickinson, J.M. (author), O'Connor, R. (author), Cohen, L.H. (author), van Thiel, C.F. (author)
The synthesis and first antimicrobial evaluation of farnesyl diphosphate mimetics are described. Several analogues (10, 12, 13, and 20) are inhibitors of Candida albicans, Shizosaccharomyces pombe, and Saccharomyces cerevisiae. The activities of analogues 10, 12, and 13, which contain a ω-phenyl moiety and a diphosphate isostere, are not...
article 2003
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Termorshuizen, A.J. (author), Volker, D. (author), Blok, W.J. (author), ten Brummeler, E. (author), Hartog, B.J. (author), Janse, J.D. (author), Knol, W. (author), Wenneker, M. (author), TNO Voeding (author)
Five pathogens were added to vegetable, fruit and garden waste and their survival was studied during mesophilic (maximum temperature 40°C) anaerobic digestion. Digestion during 6 weeks took place with a 50/50% (v/v) ratio of digested and fresh, undigested material, respectively. Survival of the plant pathogens Fusarium oxysporum f.sp. asparagi...
article 2003
document
Anderson, D. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO BIBRA (author)
Butadiene (BD) and its 2-methyl analogue, isoprene, have been extensively studied in animals and BD in population studies. Both chemicals are metabolised by liver cytochrome P450 dependent monogenases to monoepoxide and diepoxide intermediates. The diepoxide intermediates of both compounds were mutagenic in Salmonella typhimurium. However,...
article 2001
document
Sreeramulu, G. (author), Zhu, Y. (author), Knol, W. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Fermented tea drink, Kombucha, can inhibit the growth of Shigella sonnei, Escherichia coli, Salmonella enteritidis and Salmonella typhimurium. Several metabolites were analyzed every two days during a 14-day Kombucha fermentation. Levels of acetic acid and gluconic acid were found to increase with fermentation time. No lactic acid or ethanol was...
article 2001
document
Krul, C.A.M. (author), Luiten-Schuite, A. (author), Tenfelde, A. (author), van Ommen, B. (author), Verhagen, H. (author), Havenaar, R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
An in vitro gastrointestinal model, which simulates the conditions in the human digestive tract, was used to determine potential antimutagenic activity of extracts of black tea and green tea. In this paper, results are presented on the availability for absorption of potential antimutagenic compounds present in tea and on the influence of the...
article 2001
document
Krul, C.A.M. (author), Luiten-Schuite, A. (author), Baan, R. (author), Verhagen, H. (author), Mohn, G. (author), Feron, V. (author), Havenaar, R. (author)
The TNO gastro-Intestinal tract Model (TIM) is a dynamic computer-controlled in vitro system that mimics the human physiological conditions in the stomach and small intestine. In the current TIM physiological parameters such as pH, temperature, peristaltic movements, secretion of digestion enzymes, bile and pancreatic juices, and absorption of...
article 2000
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Kappers, W.A. (author), van Och, F.M.M. (author), de Groene, E.M. (author), Horbach, G.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Three different in vitro mutation assays were used to investigate the involvement of cytochrome P450 enzymes in the activation of the nitro- polycyclic aromatic hydrocarbons (nitroPAHs) 1-nitropyrene and 2- nitrofluorene and their reduced metabolites amino-polycyclic aromatic hydrocarbons (aminoPAHs) 1-aminopyrene and 2-aminofluorene....
article 2000
document
Sreeramulu, G. (author), Zhu, Y. (author), Knol, W. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Kombucha was prepared in a tea broth (0.5% w/v) supplemented with sucrose (10% w/v) by using a commercially available starter culture. The pH decreased steadily from 5 to 2.5 during the fermentation while the weight of the 'tea fungus' and the OD of the tea broth increased through 4 days of the fermentation and remained fairly constant...
article 2000
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Turnbull, D. (author), Frankos, V.H. (author), van Delft, J.H.M. (author), de Vogel, N. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Plant stanol esters from wood and vegetable oil sources were tested for genotoxicity in bacterial (Salmonella typhimurium) and mammalian cell (L5178Y) gene mutation assays and in a mammalian cell chromosome aberration assay (CHO cells). The two stanol ester formulations were tested separately at doses up to the limit of solubility, with and...
article 1999
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Rompelberg, C.J.M. (author), Evertz, S.J.C.J. (author), Bruijntjes-Rozier, G.C.D.M. (author), van den Heuvel, P.D. (author), Verhagen, H. (author), TNO Voeding (author)
The influence of in vivo treatment with eugenol on established mutagens was studied to determine whether eugenol has antigenotoxic potential. The effects of eugenol in rats was investigated in the unscheduled DNA synthesis (UDS) assay with established mutagens and the Salmonella typhimurium mutagenicity assay. In addition, the effect of in vitro...
article 1996
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Coenen, T.M.M. (author), Schoenmakers, A.C.M. (author), Verhagen, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Barlican, a β-glucanase enzyme obtained from Trichoderma reesei, was produced by a fermentation process and subjected to a series of toxicological tests to document its safety for use as a feed additive. The enzyme product was examined for general oral toxicity, inhalation toxicity, irritation to eye and skin, skin sensitization and mutagenic...
article 1995
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Wilmer, J.W.G.M. (author), Spit, B.J. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
The effects of 3 different retinoids (all-trans-retinol, all-trans-retinoic acid, and all-trans-retinyl acetate) on the mutagenic activity of cigarette-smoke condensate were investigated in Salmonella typhimurium TA98. Neither an enhancing nor an inhibitory effect of the retinoids on the mutagenicity of cigarette-smoke condensate was observed....
article 1986
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Mattern, I.E. (author), Cocchiarella, L. (author), van Kralingen, C.G. (author), Lohman, P.H.M. (author), Medisch Biologisch Laboratorium TNO (author)
Eleven platinum compounds with nitrogen donor ligands, previously tested for anti-tumour activity were studied for induction of prophage lambda and for mutagenicity in the Ames assay, with various strains of Salmonella. The compounds included cis and trans isomers of Pt(II) and Pt(IV) complexes and were tested with and without metabolic...
article 1982
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Wade, D.R. (author), Lohman, P.H.M. (author), Mattern, I.E. (author), Berends, F. (author), Medisch Biologisch Laboratorium TNO (author)
A commercial sample of the tuberculostatic drug isoniazid (INH) was found to have a weak mutagenic activity towards Salmonella typhimurium strains TA100 and TA1535. The addition of a rat or mouse liver homogenate to the test system decreased the mutagenic effect of INH. Hydrazine, an impurity of the INH sample, was also weakly mutagenic in...
article 1981
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Wade, D.R. (author), Lohman, P.H.M. (author), Medisch Biologisch Laboratorium TNO (author)
Chemicals/CAS: hydrazine, 10217-52-4, 13775-80-9, 18500-32-8, 302-01-2, 7803-57-8; isoniazid, 54-85-3, 62229-51-0, 65979-32-0; manganese, 16397-91-4, 7439-96-5
article 1980
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Kilbey, B.J. (author), Igali, S. (author), Lohman, P.H.M. (author), Medisch Biologisch Laboratorium TNO (author)
A statement of general principles and minimal criteria for the screening of chemicals for potential mutagenicity in man that may be used as guidelines for regulatory agencies and industrial organisations. To make clear the potentialities and current limitations of short-term mutagenicity testing for the prediction of genetic and carcinogenic...
article 1978
Searched for: subject:"Salmonella%5C+typhimurium"
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