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Allaix, D.L. (author), bigaj-van Vliet, A. (author), Cerar, B. (author)Road and railway infrastructure networks form the backbone of European transportation systems, carrying more than 80% of passenger and 50% of goods transport in Europe. Bridges and tunnels which are critical elements of the transport infrastructure networks, have in many cases reached their design service life and keep ageing, with the...conference paper 2022
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Sanchez, M.M. (author), Elfring, J. (author), Silvas, E. (author), van de Molengraft, R. (author)To operate safely, an automated vehicle (AV) must anticipate how the environment around it will evolve. For that purpose, it is important to know which prediction models are most appropriate for every situation. Currently, assessment of prediction models is often performed over a set of trajectories without distinction of the type of movement...conference paper 2022
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Rankouhi, T.R. (author), van Keulen, D. (author), Tempel, D. (author), Venhorst, J. (author)Background: Cardiovascular disease (CVD) is a leading cause of death worldwide. It is predicted that approximately 23.6 million people will die from CVDs annually by 2030. Therefore, there is a great need for an effective therapeutic approach to combat this disease. The European Cardiovascular Target Discovery (CarTarDis) consortium identified...article 2022
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Bigaj - Van Vliet, A.J. (author), Allaix, D.L. (author), Kohler, D. (author), Scibilia, E. (author)This contribution is outlining the vision and approach developed in the IM-SAFE project towards the standardisation of monitoring, data-informed safety assessment and predictive maintenance policies of bridges and tunnels considering the integration of digital innovations and reports on the initial activity in the IM-SAFE project [1] that is...conference paper 2022
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Allaix, D.L. (author), Bigaj-van Vliet, A. (author)Aiming to ensure the safety of the transport infrastructure during operation through the improvement of maintenance policies across Europe, the European Commission opened in 2019 the call for the Coordination and Support Action (CSA) “Monitoring and safety of transport infrastructure”. The main goal of this CSA is to support the preparation of a...conference paper 2022
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de Gelder, E. (author), op den Camp, O.M.G.C. (author)The development of Autonomous Vehicles (AVs) has made significant progress in the last years and it is expected that AVs will soon be introduced on our roads. An important aspect in the development of AVs is the assessment of their safety. As traditional methods for safety assessment of vehicles are not feasible to be performed for AVs within...conference paper 2020
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Soeteman-Hernandez, L.G. (author), Apostolova, M.D. (author), Bekker, C. (author), Dekkers, S. (author), Grafström, R.C. (author), Groenewold, M. (author), Handzhiyski, Y. (author), Herbeck-Engel, P. (author), Hoehener, K. (author), Karagkiozaki, V. (author), Kelly, S. (author), Kraegeloh, A. (author), Logothetidis, S. (author), Micheletti, C. (author), Nymark, P. (author), Oomen, A. (author), Oosterwijk, T. (author), Rodríguez-LLopis, I. (author), Sabella, S. (author), sanchez Jiménez, A. (author), Sips, A.J.A.M. (author), Suarez-Merino, B. (author), Tavernaro, I. (author), van Engelen, J. (author), Wijnhoven, S.W.P. (author), Noorlander, C.W. (author)Nanotechnologies are characterized by a growing legacy of already marketed and novel manufactured nanomaterials (MNMs) and nano-enabled products with a lack of a coherent risk governance system to address their safety effectively. In response to this situation, a proactive system is needed to minimize the gap between the pace of innovation and...article 2019
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Meijerink, M. (author), van den Broek, T.J. (author), Dulos, R. (author), Garthoff, J. (author), Knippels, L. (author), Knipping, K. (author), Harthoorn, L. (author), Houben, G. (author), Verschuren, L. (author), van Bilsen, J. (author)To assess the safety and efficacy of oral immune interventions, it is important and required by regulation to assess the impact of those interventions not only on the immune system, but also on other organs such as the gut as the porte d'entrée. Despite clear indications that the immune system interacts with several physiological functions of...article 2019
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- Ploeg, J. (author), de Gelder, E. (author), Slavik, M. (author), Querner, E. (author), Webster, T. (author), de Boer, N. (author) conference paper 2018
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Zhu, H. (author), Bouhifd, M. (author), Donley, E. (author), Egnash, L. (author), Kleinstreuer, N. (author), Kroese, E.D. (author), Liu, Z. (author), Luechtefeld, T. (author), Palmer, J. (author), Pamies, D. (author), Shen, J. (author), Strauss, V. (author), Wu, S. (author), Hartung, T. (author)Read-across, i.e., filling toxicological data gaps by relating to similar chemicals for which test data are available, is usually done based on chemical similarity. Besides structure and physico-chemical properties, biological similarity based on biological data adds extra strength to this process. In the simplest case, chemically similar...article 2016
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Koster, S. (author), Leeman, W.R. (author), Verheij, E.R. (author), Dutman, A.E. (author), van Stee, L.L.P. (author), Munch Nielsen, L. (author), Ronsmans, S. (author), Noteborn, H. (author), Krul, L. (author)A main challenge in food safety research is to demonstrate that processing of foodstuffs does not lead to the formation of substances for which the safety upon consumption might be questioned. This is especially so since food is a complex matrix in which the analytical detection of substances, and consequent risk assessment thereof, is difficult...article 2015
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Nohynek, G.J. (author), Skare, J.A. (author), Meuling, W.J.A. (author), Wehmeyer, K.R. (author), de Bie, A.T.H.J. (author), Vaes, W.H.J. (author), Dufour, E.K. (author), Fautz, R. (author), Steiling, W. (author), Bramante, M. (author), Toutain, H. (author)Systemic exposure was measured in humans after hair dyeing with oxidative hair dyes containing 2.0% (A) or 1.0% (B) [14C]-p-phenylenediamine (PPD). Hair was dyed, rinsed, dried, clipped and shaved; blood and urine samples were collected for 48 hours after application. [14C] was measured in all materials, rinsing water, hair, plasma, urine and...article 2015
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Koster, S. (author), Rennen, M. (author), Leeman, W. (author), Houben, G. (author), Muilwijk, B. (author), van Acker, F. (author), Krul, L. (author)One of the main challenges in food contact materials research is to prove that the presence of non-intentionally added substances (NIAS) is not a safety issue. Migration extracts may contain many unknown substances present at low concentrations. It is difficult and time-consuming to identify all these potential NIAS and concurrently to assess...article 2014
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Madsen, C.B. (author), Houben, G. (author), Hattersley, S. (author), Crevel, R.W.R. (author), Remington, B.C. (author), Baumert, J.L. (author)Regulatory thresholds for allergenic foods have not yet been developed. This means that public and industrial risk managers do not have regulatory thresholds to decide if a content or level of contamination is acceptable or not. For a long time, data have been inadequate to define safe thresholds for food allergens. More and more challenge data...bookPart 2013
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Steenbergen, R.D.J.M. (author), de Boer, A. (author), van der Veen, C. (author)Evaluating and upgrading concrete slab bridges is an important issue. A large part of the existing infrastructure has been built about 50 years ago and the design life has been reached or will be reached in the near future. Also traffic loads have increased significantly over the last 50 years. These structures need to be reassessed in order to...conference paper 2011
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Poot, A. (author), Quik, J.T.K. (author), Veld, H. (author), Koelmans, A.A. (author), TNO Bouw en Ondergrond (author)Black Carbon (BC) quantification methods are reviewed, including new Rock-Eval 6 data on BC reference materials. BC has been reported to have major impacts on climate, human health and environmental quality. Especially for risk assessment of persistent organic pollutants (POPs) it is important to account for risk reduction caused by BC, as...article 2009
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Scholten, N.P.M. (author), Vrouwenvelder, A.C.W.M. (author), TNO Bouw en Ondergrond (author)Since 1992 there have been a number of proposals to renew calculation methods available to assess the structural safety of existing buildings. But without operational results. Upon publication of the Eurocodes NL decided to renew and to include them in the Dutch building regulations. The question was how. One decided to develop a new Dutch...conference paper 2009
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Dole, P. (author), Voulzatis, Y. (author), Vitrac, O. (author), Reynier, A. (author), Hankemeier, T. (author), Aucejo, S. (author), Feigenbaum, A. (author), TNO Kwaliteit van Leven (author)Functional barriers form parts of multi-layer packaging materials, which are deemed to protect the food from migration of a broad range of contaminants, e.g. those associated with reused packaging. Often, neither the presence nor the identity of the contaminants is known, so that safety assessment of the materials has to rely on predictive tools...article 2006
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Germolec, D.R. (author), Kashon, M. (author), Nyska, A. (author), Kuper, C.F. (author), Portier, C. (author), Kommineni, C. (author), Johnson, K.A. (author), Luster, M.I. (author), TNO Voeding (author)The accuracy of extended histopathology to detect immunotoxic chemicals in female B6C3F1 mice was evaluated under the auspices of the National Toxicology Program (NTP). A workgroup was formed consisting of four pathologists who conducted extended histopathological evaluation of lymphoid tissues obtained from a subset of NTP toxicology studies,...article 2004
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König, A. (author), Cockburn, A. (author), Crevel, R.W.R. (author), Debruyne, E. (author), Grafstroem, R. (author), Hammerling, U. (author), Kimber, I. (author), Knudsen, I. (author), Kuiper, H.A. (author), Peijnenburg, A.A.C.M. (author), Penninks, A.H. (author), Poulsen, M. (author), Schauzu, M. (author), Wal, J.M. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)This paper provides guidance on how to assess the safety of foods derived from genetically modified crops (GM crops); it summarises conclusions and recommendations of Working Group 1 of the ENTRANSFOOD project. The paper provides an approach for adapting the test strategy to the characteristics of the modified crop and the introduced trait, and...article 2004
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