- document
-
Bajard, L. (author), Adamovsky, O. (author), Audouze, K. (author), Baken, K. (author), Barouki, R. (author), Beltman, J. (author), Beronius, A. (author), Bonefeld-Jørgensen, E.C. (author), Cano-Sancho, G. (author), de Baat, M.L. (author), Di Tillio, F. (author), Fernández, M.F. (author), FitzGerald, R.E. (author), Gundacker, C. (author), Hernández, A.F. (author), Hilscherova, K. (author), Karakitsios, S. (author), Kuchovska, E. (author), Long, M. (author), Luijten, M. (author), Majid, S. (author), Marx-Stoelting, P. (author), Mustieles, V. (author), Negi, C.K. (author), Sarigiannis, D. (author), Scholz, S. (author), Sovadinova, I. (author), Stierum, R. (author), Tanabe, S. (author), Tollefsen, K.E. (author), van den Brand, A.D. (author), Vogs, C. (author), Wielsøe, M. (author), Wittwehr, C. (author), Blaha, L. (author)While human regulatory risk assessment (RA) still largely relies on animal studies, new approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative models are increasingly used to evaluate chemical hazards. Moreover, human epidemiological studies with biomarkers of effect (BoE) also play an invaluable role in...article 2023
- document
-
Fransman, W. (author), Otten, W. (author), Marquart, H. (author), Preuhs, K. (author), Willemsen, J. (author), Boumann, H. (author), Gerritsen, R. (author)Objectives: Within the chemical legislation, REACH was implemented in order to improve safe working conditions with hazardous substances. Literature and real-life experiences by those concerned have shown that there are still gaps with a need for improved risk communication. This study elaborated on how information provided by REACH is...article 2023
- document
-
Santonen, T. (author), Mahiout, S. (author), Alvito, P. (author), Apel, P. (author), Bessems, J. (author), Bil, W. (author), Borges, T. (author), Bose-O'Reilly, S. (author), Buekers, J. (author), Canas Portilla, A.I. (author), Calvo, A.C. (author), de Alba González, M. (author), Dominguez-Morueco, N. (author), Lopez, M.E. (author), Falnoga, I. (author), Gerofke, A. (author), Caballero, M.D.C.G. (author), Horvat, M. (author), Huuskonen, P. (author), Kadikis, N. (author), Kolossa-Gehring, M. (author), Lange, R. (author), Louro, H. (author), Martins, C. (author), Meslin, M. (author), Niemann, L. (author), Diaz, S.P. (author), Plichta, V. (author), Porras, S.P. (author), Rousselle, C. (author), Scholten, B. (author), Silva, M.J. (author), Šlejkovec, Z. (author), Tratnik, J.S. (author), Joksic, A.Š. (author), Tarazona, J.V. (author), Uhl, M. (author), van Nieuwenhuyse, A. (author), Viegas, S. (author), Vinggaard, A.M. (author), Woutersen, M. (author), Schoeters, G. (author)One of the aims of the European Human Biomonitoring Initiative, HBM4EU, was to provide examples of and good practices for the effective use of human biomonitoring (HBM) data in human health risk assessment (RA). The need for such information is pressing, as previous research has indicated that regulatory risk assessors generally lack knowledge...article 2023
- document
-
Najjar, A. (author), Punt, A. (author), Wambaugh, J. (author), Paini, A. (author), Ellison, C. (author), Fragki, S. (author), Bianchi, E. (author), Zhang, F. (author), Westerhout, J. (author), Mueller, D. (author), Li, H. (author), Shi, Q. (author), Gant, T.W. (author), Botham, P. (author), Bars, R. (author), Piersma, A. (author), van Ravenzwaay, B. (author), Kramer, N.I. (author)With an increasing need to incorporate new approach methodologies (NAMs) in chemical risk assessment and the concomitant need to phase out animal testing, the interpretation of in vitro assay readouts for quantitative hazard characterisation becomes more important. Physiologically based kinetic (PBK) models, which simulate the fate of chemicals...article 2022
- document
-
Houben, G.F. (author), Blom, W.M. (author), Meijerink, M. (author)Food allergy has been recognized already in early history as a condition triggered in some individuals upon consumptions of specific foods. However, its recognition as an essential element to be addressed in food safety management is of much more recent date. As a consequence, risk assessment and risk management practices for food allergy are...bookPart 2022
- document
-
Rankouhi, T.R. (author), van Keulen, D. (author), Tempel, D. (author), Venhorst, J. (author)Background: Cardiovascular disease (CVD) is a leading cause of death worldwide. It is predicted that approximately 23.6 million people will die from CVDs annually by 2030. Therefore, there is a great need for an effective therapeutic approach to combat this disease. The European Cardiovascular Target Discovery (CarTarDis) consortium identified...article 2022
- document
-
Blom, W.M. (author), Westerhout, J. (author), Baumert, J.L. (author), Meima, M.Y. (author), Turner, P.J. (author), Ebisawa, M. (author), Yanagida, N. (author), Remington, B.C. (author), Houben, G.F. (author)Access to Eliciting Doses (ED) for allergens enables advanced food allergen risk assessment. Previously, the full ED range for 14 allergenic foods, including milk, and recommendations for their use were provided (Houben et al., 2020). Additional food challenge studies with cow's milk-allergic patients added 247 data points to the original...article 2022
- document
-
Semertzis, I. (author), Rajkumar, V.S. (author), Ştefanov, A. (author), Fransen, F. (author), Palensky, P. (author)Over the past decade, the number of cyber attack incidents targeting critical infrastructures such as the electrical power system has increased. To assess the risk of cyber attacks on the cyber-physical system, a holistic approach is needed that considers both system layers. However, the existing risk assessment methods are either qualitative in...conference paper 2022
- document
- de Bruin, G.J. (author), Pereira Barata, A. (author), van den Herik, H.J. (author), Takes, F.W. (author), Veenman, C.J. (author) article 2022
- document
-
Remington, B.C. (author), Baumert, J. (author), Blom, W.M. (author), Bucchini, L. (author), Buck, N. (author), Crevel, R. (author), de Mooij, F. (author), Flanagan, S. (author), Hindley, J. (author), Javed, B. (author), Stavropoulou, D.A. (author), van den Dungen, M.W. (author), van Ravenhorst, M. (author), Wang, S. (author), Walker, M. (author)Quantitative risk assessment (QRA) for allergens exists in many different forms with different requirements placed on the risk assessor depending on the question that needs to be answered. An electronic workshop held in October 2020 and comprising representatives from a wide range of food allergy and allergen stakeholder groups identified that a...article 2022
- document
-
Fransman, W. (author), Arnone, M. (author), Borghi, F. (author), Cattaneo, A. (author), Cavallo, D.M. (author), Cherrie, J.W. (author), Franken, R. (author), Galea, K.S. (author), van der Haar, R. (author), Heussen, G.A.H. (author), Jensen, K.A. (author), Koponen, M. (author), Koppisch, D. (author), Kromhout, H. (author), Luo, KY.S. (author), McNally, K. (author), Säämänen, A. (author), Spinazzè, A. (author), van Tongeren, M. (author), Jeroen, (author), Vanoirbeek, J. (author), Verpaele, S. (author), Vetter, D. (author), Viegas, S. (author), Warren, N. (author)In this article, we have responded to the key statements in the article by Koivisto et al. (2022) that were incorrect and considered to be a biased critique on a subset of the exposure models used in Europe (i.e. ART and Stoffenmanager®) used for regulatory exposure assessment. We welcome scientific discussions on exposure modelling (as was done...article 2022
- document
-
Oosterman, D.T. (author), Langenkamp, W.H. (author), van Bergen, E.L. (author)In this paper we describe our initial findings on a method for improving anomaly detection on a dataset with scarcely labeled data, based on an ongoing use-case with the Belgian Customs Administration (BCA). Data on shipping containers is used to predict the level of risk associated with a shipment, as well as the probability that the shipment...conference paper 2022
- document
-
Krishnan, S. (author), Vermeulen, R. (author), Pronk, A. (author), Gyori, B.M. (author), Bachman, J.A. (author), Vlaanderen, J. (author), Stierum, R. (author)BACKGROUND: Mechanistic data is increasingly used in hazard identification of chemicals. However, the volume of data is large, challenging the efficient identification and clustering of relevant data. OBJECTIVES: We investigated whether evidence identification for hazard assessment can become more efficient and informed through an automated...article 2022
- document
-
Heedt, S. (author), Kouwenhoven, L.P. (author)We systematically study three-terminal InSb-Al nanowire devices by using radio-frequency reflectometry. Tunneling spectroscopy measurements on both ends of the hybrid nanowires are performed while systematically varying the chemical potential, magnetic field, and junction transparencies. Identifying the lowest-energy state allows for the...article 2022
- document
- Meima, M.Y. (author), Blom, W.M. (author), Westerhout, J. (author), Kruizinga, A.G. (author), Remington, B.C. (author), Wheeler, M.W. (author), Houben, G.F. (author) article 2021
- document
-
Meima, M.Y. (author), Remington, B.C. (author), Blom, W.M. (author), Baumert, J.L. (author), Taylor, S.L. (author), Jeffery, B. (author), Robert, M.C. (author), Houben, G.F. (author), Lucas Luijckx, N.B. (author)Allergenic food particles (typically ~0.5–5 mm) may unintentionally end up in food products during production and can pose a risk for the allergic consumer. A single particle can provoke allergic symptoms in an allergic consumer when the dose of allergenic protein exceeds minimal eliciting doses. However, there is a lack of fundamental knowledge...article 2021
- document
-
Krystek, P. (author), Shandilya, N. (author), Fransman, W. (author)Driven by the concept of the ‘four generations of nanomaterials’, the current state of the knowledge on risk assessment of future generation is explored for active nanomaterials. Through case studies, we identify challenges and evaluate the preparedness of characterization methods, available risk assessment modeling tools, and analytical...article 2021
- document
-
Remington, B.C. (author), Westerhout, J. (author), Dubois, A.E.J. (author), Blom, W.M. (author), Kruizinga, A.G. (author), Taylor, S.L. (author), Houben, G.F. (author), Baumert, J.L. (author)Food allergen threshold dose distributions are used in food allergen risk assessment to determine the level of risk within a food-allergic population to a defined exposure amount of allergenic food protein and to help inform allergen risk management decisions. There has been a long-standing interest in determining threshold dose distributions...article 2021
- document
-
Taylor, S.L. (author), Houben, G.F. (author), Blom, W.M. (author), Westerhout, J. (author), Remington, B.C. (author), Crevel, R.W.R. (author), Brooke-Taylor, S. (author), Baumert, J.L. (author)Background. Soy is globally recognized as a commonly allergenic food. The VITAL (Voluntary Incidental Trace Allergen Labeling) Scientific Expert Panel (VSEP) of the Allergen Bureau of Australia & New Zealand used data on minimal reactive doses in low-dose clinical challenges of soy-allergic individuals to elaborate and propose the first...article 2021
- document
-
den Hollander, R.J.M. (author), van Rooij, S.B. (author), van den Broek, S.P. (author), Dijk, J. (author)An important surveillance task during naval military operations is early risk assessment of vessels. The potential risk that a vessel poses will depend on the vessel type, and vessel classification is therefore a basic technique in risk assessment. Although automatic identification by AIS is widely available, the AIS transponders can potentially...conference paper 2021