Searched for: subject%3A%22Risk%255C%2Banalysis%22
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Steijn, W.M.P. (author), van Oosterhout, J. (author), van Gulijk, C. (author)
This work provides insight into the scientific-ground work for the development of digital safety tools for human-robot interactions; GRIP - Guarding Robot Interaction Performance. GRIP is a digital safety management system under development for human-robot interactions (HRI) in an Industry 4.0 setting. GRIP draws knowledge from different sources...
conference paper 2021
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de Gelder, E. (author), Elrofai, H. (author), Saberi, A.K. (author), Paardekooper, J.-P. (author), Op Den Camp, O. (author), de Schutter, B. (author)
The development of safety validation methods is essential for the safe deployment and operation of Automated Driving Systems (ADSs). One of the goals of safety validation is to prospectively evaluate the risk of an ADS dealing with real-world traffic. ISO 26262 and ISO/DIS 21448, the leading standards in automotive safety, provide an approach to...
article 2021
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Grierer, K. (author), Isigonis, P. (author), Franken, R. (author), Wigger, H. (author), Bossa, N. (author), Janer, G. (author), Rycroft, T. (author), Kennedy, A.J. (author), Hansen, S.F. (author)
It has now been more than 15 years since scientists, researchers, risk analyzers, policymakers, and other decision-makers initiated comprehensive investigations into the potential environmental, health, and safety risks of engineered nanomaterials. During this time, various tools have been proposed and/or developed to screen potential...
bookPart 2021
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Aliman, N.M. (author), Kester, L.J.H.M. (author), Yampolskiy, R. (author)
In the last years, artificial intelligence (AI) safety gained international recognition in the light of heterogeneous safety-critical and ethical issues that risk overshadowing the broad beneficial impacts of AI. In this context, the implementation of AI observatory endeavors represents one key research direction. This paper motivates the need...
article 2021
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Steijn, W.M.P. (author), van Kampen, J.N. (author), van der Beek, D. (author), Groeneweg, J. (author), van Gelder, P.H.A.J.M. (author)
Quantitative Risk Analysis (QRA) is a standard tool in some high-risk industries (such as the on- and offshore exploration and production and chemical industry). Presently, existing knowledge concerning human error likelihood and human reliability assessment is insufficiently represented in QRAs. In this paper we attempt to implement the...
article 2020
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Schoen, E.D. (author), Eendebak, P.T. (author), Goos, P. (author)
A conference design is a rectangular matrix with orthogonal columns, one zero in each column, at most one zero in each row and -1's and +1's elsewhere. A definitive screening design can be constructed by folding over a conference design and adding a row vector of zeroes. We prove that, for a given even number of rows, there is just one...
article 2019
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Kuper, C.F. (author), Bosland, M.C. (author)
article 2019
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Pizzol, L. (author), Hristozov, D. (author), Zabeo, A. (author), Gianpietro, B. (author), Wohlleben, W. (author), Koivisto, A.J. (author), Jensen, K.A. (author), Fransman, W. (author), Stone, V. (author), Marcomini, A. (author)
The increasing use of engineered nanomaterials (ENMs) in nano-enabled products (NEPs) has raised societal concerns about their possible health and ecological implications. To ensure a high level of human and environmental protection it is essential to properly estimate the risks of these new materials and to develop adequate risk management...
article 2019
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Lozano-Ojalvo, D. (author), Benede, S. (author), Antunes, C.M. (author), Bavaro, S.L. (author), Bouchaud, G. (author), Costa, A. (author), Denery-Papini, S. (author), Diaz-Perales, A. (author), Garrido-Arandia, M. (author), Gavrovic-Jankulovic, M. (author), Hayen, S. (author), Martinez-Blanco, M. (author), Molina, E. (author), Monaci, L. (author), Pieters, R.H.H. (author), Villemin, C. (author), Wichers, H.J. (author), Wroblewska, B. (author), Willemsen, L.E.M. (author), Roggen, E.L. (author), van Bilsen, J.H.M. (author)
Background: Before introducing proteins from new or alternative dietary sources into the market, a compressive risk assessment including food allergic sensitization should be carried out in order to ensure their safety. We have recently proposed the adverse outcome pathway (AOP) concept to structure the current mechanistic understanding of the...
article 2019
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Schönemann, V. (author), Winner, H. (author), Glock, T. (author), Otten, S. (author), Sax, E. (author), Boeddeker, B. (author), Verhaeg, G. (author), Tronci, F. (author), Padilla, G.G. (author)
New safety challenges have to be targeted due to the development of fully automated vehicles in the upcoming future. However, designing safe vehicle automation systems is essential. This work presents a scenario-based methodology for functional safety analysis according to the ISO 26262 using the example of automated valet parking . The vehicle...
conference paper 2019
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Houben, G. (author), Blom, M. (author), Alvito, P. (author), Assuncao, R. (author), Crevel, R. (author), Faeste, C.K. (author), Le, T.M. (author), Madsen, C.B. (author), Remington, B. (author), Stroheker, T. (author), Vassilopoulou, E. (author), Verhoeckx, K. (author), Ayiarovska, J. (author), Constable, A. (author)
Many food innovations rely on the introduction and use of new or modified proteins. New or modified food proteins may lead to major health risks due to their inherent potential to cause food allergy. Currently, the pre-market allergenicity assessment for new or modified food proteins and protein sources relies on methods for identifying...
article 2019
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Versluis, A. (author), van Os-Medendorp, H. (author), Blom, W.M. (author), Michelsen-Huisman, A.D. (author), Castenmiller, J.J.M. (author), Noteborn, H.P.J.M. (author), Houben, G.F. (author), Knulst, A.C. (author)
Background: Cofactors, such as physical exercise and alcohol intake, might be associated with the severity or occurrence of food allergic reactions. Objective: To gain insight into the frequency of presence of potential cofactors in accidental food allergic reactions in adults and to what extent these factors influence the severity and...
article 2019
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Vazquez, A.R. (author), Goos, P. (author), Schoen, E.D. (author)
Two-level orthogonal arrays of N runs, k factors, and a strength of 3 provide suitable fractional factorial designs in situations where many of the main effects are expected to be active, as well as some two-factor interactions. If they consist of N/2 mirror image pairs, these designs are fold-over designs. They are called even and provide at...
article 2019
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Kuijpers, E. (author), Pronk, A. (author), Koivisto, A.J. (author), Jensen, K.A. (author), Vermeulen, R. (author), Fransman, W. (author)
Introduction. Knowledge on the exposure characteristics, including release of nanomaterials, is especially needed in the later stages of nano-enabled products’ life cycles to perform better occupational risk assessments. The objective of this study was to assess the concentrations during sawing and drilling in car bumpers containing multi-walled...
article 2019
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Schinkel, J. (author), Heerderik, D. (author), Helsloot, I. (author), Kraaijenbrink, S. (author), Vis, J. (author)
In veel situaties is momenteel onduidelijk wat de blootstelling aan asbest (door inhalatie) werkelijk is, en daarmee wat de bijbehorende gezondheidsrisico’s zijn. Hierdoor is het dus veelal niet mogelijk om vast te stellen wat proportionele veiligheidsmaatregelen zijn.
report 2019
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Semenzina, E. (author), Subramanian, V. (author), Pizzo, L. (author), Zabeo, A. (author), Fransman, W. (author), Oksel, C. (author), Hristozov, D. (author), Marcomini, A. (author)
The widespread use of engineered nanomaterials (ENMs) in consumer products and the overwhelming uncertainties in their ecological and human health risks have raised concerns regarding their safety among industries and regulators. There has been an ongoing debate over the past few decades on ways to overcome the challenges in assessing and...
article 2019
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Savic, N. (author), Gasic, B. (author), Schinkel, J. (author), Vernez, D. (author)
The Advanced REACH Tool (ART) is the most sophisticated tool used for evaluating exposure levels under the European Union's Registration, Evaluation, Authorisation and restriction of CHemicals (REACH) regulations. ART provides estimates at different percentiles of exposure and within different confidence intervals (CIs). However, its performance...
article 2018
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Dankers, A.C.A. (author), Kuper, C.F. (author), Boumeester, A.J. (author), Fabriek, B.O. (author), Kooter, I.M. (author), Gröllers-Mulderij, M. (author), Tromp, P. (author), Nelissen, I. (author), Zondervan-Van Den Beuken, E.K. (author), Vandebriel, R.J. (author)
Exposure of humans to metal oxide nanoparticles (NPs) occurs mainly via air, and inhaled metal oxide NPs may generate inflammation. The aim of this study was to investigate the proinflammatory potential of six metal oxide NPs (CeO2, Mn2O3, CuO, ZnO, Co3O4 and WO3; 27–108 μg ml−1) using human primary 3-dimensional airway epithelium (MucilAir™)...
article 2018
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Koivisto, A.J. (author), Pizzol, L. (author), Basei, G. (author), Zabeo, A. (author), Mackevica, A. (author), Hansen, S.F. (author), Gosens, I. (author), Cassess, F.R. (author), de Jong, W. (author), Koivisto, A.J. (author), Neubauer, N. (author), Sanchaz, J.A. (author), Semenzin, E. (author), Subramanian, V. (author), Fransman, W. (author), Jensen, K.A. (author), Wohlleben, W. (author), Stone, V. (author), Marcomini, A. (author)
The use of nano-scale copper oxide (CuO) and basic copper carbonate (Cu2(OH)2CO3) in both ionic and micronized wood preservatives has raised concerns about the potential of these substances to cause adverse humans health effects. To address these concerns, we performed quantitative (probabilistic) human health risk assessment (HHRA) along the...
article 2018
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Goede, H.A. (author), Ploeg, D. (author), Schinkel, J.M. (author)
The development of a dermal exposure model is a challenge because of the complexity of dermal exposure processes on one hand, and the scarcity of good quality and contextually-rich dermal exposure measurements. Dermal exposure modelling is further complicated by the difficulty of measuring dermal exposure due to the lack of standardised methods ...
report 2018
Searched for: subject%3A%22Risk%255C%2Banalysis%22
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