Searched for: subject:"Risk%5C+Assessment"
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Meima, M.Y. (author), Blom, W.M. (author), Westerhout, J. (author), Kruizinga, A.G. (author), Remington, B.C. (author), Wheeler, M.W. (author), Houben, G.F. (author)
article 2021
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Taylor, S.L. (author), Houben, G.F. (author), Blom, W.M. (author), Westerhout, J. (author), Remington, B.C. (author), Crevel, R.W.R. (author), Brooke-Taylor, S. (author), Baumert, J.L. (author)
Background. Soy is globally recognized as a commonly allergenic food. The VITAL (Voluntary Incidental Trace Allergen Labeling) Scientific Expert Panel (VSEP) of the Allergen Bureau of Australia & New Zealand used data on minimal reactive doses in low-dose clinical challenges of soy-allergic individuals to elaborate and propose the first...
article 2021
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Remington, B.C. (author), Westerhout, J. (author), Meima, M.Y. (author), Blom, W.M. (author), Kruizinga, A.G. (author), Wheeler, M.W. (author), Taylor, S.L. (author), Houben, G.F. (author), Baumert, J.L. (author)
Food allergy and allergen management are important global public health issues. In 2011, the first iteration of our allergen threshold database (ATDB) was established based on individual NOAELs and LOAELs from oral food challenge in roughly 1750 allergic individuals. Population minimal eliciting dose (EDp) distributions based on this dataset...
article 2020
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Steijn, W.M.P. (author), van Kampen, J.N. (author), van der Beek, D. (author), Groeneweg, J. (author), van Gelder, P.H.A.J.M. (author)
Quantitative Risk Analysis (QRA) is a standard tool in some high-risk industries (such as the on- and offshore exploration and production and chemical industry). Presently, existing knowledge concerning human error likelihood and human reliability assessment is insufficiently represented in QRAs. In this paper we attempt to implement the...
article 2020
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Madsen, C.B. (author), van den Dungen, M.W. (author), Cochrane, S. (author), Houben, G.F. (author), Knibb, R.C. (author), Knulst, A.C. (author), Ronsmans, S. (author), Yarham, R.A.R. (author), Schnadt, S. (author), Turner, P.J. (author), Baumert, J. (author), Cavandoli, E. (author), Chan, C.H. (author), Warner, A. (author), Crevel, R.W.R. (author)
Substantial progress has been made in characterising the risk associated with exposure to allergens in food. However, absence of agreement on what risk is tolerable has made it difficult to set quantitative limits to manage that risk and protect allergic consumers effectively. This paper reviews scientific progress in the area and the diverse...
article 2020
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Nymark, P. (author), Bakker, M. (author), Dekkers, S. (author), Franken, R. (author), Fransman, W. (author), García-Bilbao, A. (author), Greco, D. (author), Gulumian, M. (author), Hadrup, N. (author), Halappanavar, S. (author), Hongisto, V. (author), Hougaard, K. (author), Jensen, K. (author), Kohonen, P. (author), Koivisto, A.J. (author), Dal Maso, M. (author), Oosterwijk, T. (author), Poikkimäki, M. (author), Rodriguez-Llopis, I. (author), Stierum, R. (author), Sørli, J.B. (author), Grafström, R. (author)
Advanced material development, including at the nanoscale, comprises costly and complex challenges coupled to ensuring human and environmental safety. Governmental agencies regulating safety have announced interest toward acceptance of safety data generated under the collective term New Approach Methodologies (NAMs), as such technologies...
article 2020
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McQueen, A.D. (author), Suedel, B.C. (author), de Jong, C.A.F. (author), Thomsen, F. (author)
There is an increasing international focus to understand and quantify the potential ecological risks of low-frequency underwater sounds produced from anthropogenic activities (e.g., commercial shipping, dredging, construction, and offshore energy production). For dredge operations, a risk-based approach has been proposed for identifying,...
article 2020
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Steijn, W.M.P. (author), Beek, D.A.V.D. (author), Groeneweg, J. (author), Jansen, A. (author), Oldenhof, W.A. (author), Raben, I. (author)
Last minute risk assessment (LMRA) is a well-known work method to support employees’ risk perception. However, little is known about the effectiveness of LMRA in providing this support. Here, we describe an eye-tracking experiment with which we attempted to gain more insight into the relationship between LMRA and risk perception and to assess...
article 2020
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Franken, R. (author), Heringa, M.B. (author), Oosterwijk, T. (author), dal Maso, M. (author), Fransman, W. (author), Kanerva, T. (author), Liguori, B. (author), Poikkimäki, M. (author), Rodriguez-Llopis, I. (author), Säämänen, A. (author), Stockmann-Juvala, H. (author), Suarez-Merino, B. (author), alstrup Jensen, K. (author), Stierum, R. (author)
The current work describes the interaction with various stakeholder groups to establish consensus on stage-gate specific criteria that human risk assessment (HRA) models for manufactured nanomaterials (MN) need to comply with. During the decisive steps in the innovation process, which can be described in a simplified way as stage-gates, it is...
article 2020
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Blom, W.M. (author), van Os-Medendorp, H. (author), Bijlsma, S. (author), van Dijk, A. (author), Kruizinga, A.G. (author), Rubingh, C. (author), Michelsen-Huisman, A.D. (author), Knulst, A.C. (author), Houben, G.F. (author)
Unintentional intake of allergens through food products poses a daily risk for allergic patients. Models estimating the risk of reactions mostly use intake data from general population surveys. Our study evaluates the comparability of food intake levels in the general population to those in the food allergic population. Data were collected by a...
article 2020
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van Unen, M. (author), van der Valk, K. (author), Koornneef, J. (author), Brunner, L. (author), Koenen, M. (author)
In order to make the transition to a low-carbon energy system, sustainable energy sources are required as alternatives for fossil fuels. The heating and cooling sector is of major importance for the final energy consumption in Europe, and therefore the deployment of the thermal energy sector could be a good contribution to a sustainable energy...
report 2020
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Verhoeckx, K. (author), lindholm Bøgh, K. (author), Constable, A. (author), Epstein, M.M. (author), hoffmann Sommergruber, K. (author), Holzhauser, T. (author), Houben, G. (author), Kuehn, A. (author), Roggen, E. (author), O'Mahony, L. (author), Remington, B. (author), Crevel, R. (author)
The growing world population and increased pressure on agricultural resources are driving a shortage of dietary protein sources. As a result, industry is developing more sustainable novel food protein sources such as insects, algae and duckweed and using new processing techniques. Consumer exposure to these novel or processed proteins, could...
article 2020
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Houben, G.F. (author), Baumert, J.L. (author), Blom, W.M. (author), Kruizinga, A.G. (author), Meima, M.Y. (author), Remington, B.C. (author), Wheeler, M.W. (author), Westerhout, J. (author), Taylor, S.L. (author)
Previously, we published selected Eliciting Dose (ED) values (i.e. ED01 and ED05 values) for 14 allergenic foods, predicted to elicit objective allergic symptoms in 1% and 5%, respectively, of the allergic population (Remington et al., 2020). These ED01 and ED05 values were specifically presented and discussed in the context of establishing...
article 2020
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Heusinkveld, H. (author), Braakhuis, H. (author), Gommans, R. (author), Botham, P. (author), Corvaro, M. (author), van der Laan, J.W. (author), Lewis, D. (author), Madia, F. (author), Manou, I. (author), Schorsch, F. (author), Wolterink, G. (author), Woutersen, R. (author), Corvi, R. (author), Mehta, J. (author), Luijten, M. (author)
Chemical substances are subjected to assessment of genotoxic and carcinogenic effects before being marketed to protect man and the environment from health risks. For agrochemicals, the long-term rodent carcinogenicity study is currently required from a regulatory perspective. Although it is the current mainstay for the detection of nongenotoxic...
article 2020
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Franken, R.A. (author), Kasiotis, K.M. (author), Tsakirakis, A.N. (author), Chartzela, I. (author), Anastasiadou, P. (author), Fransman, W. (author), Gerritsen-Ebben, R.M. (author), Spaan, S. (author), Goede, H. (author), Machera, K. (author), Gerritsen-Ebben, R. (author)
For many work situations only insufficient exposure data are available to perform proper risk assessment. Because measuring worker exposure can be time consuming and resource intense, the availability of reliable exposure models is important when performing risk assessments. However, the development and improvement of exposure models are...
article 2020
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Vink, J.P.M. (author), Comans, R.N.J. (author), Dijkstra, J.J. (author), Lamers, L.P.M. (author)
article 2020
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Moné, M.J. (author), Pallocca, G. (author), Escher, S.E. (author), Exner, T. (author), Herzler, M. (author), Hougaard Bennekou, S. (author), Kamp, H. (author), Kroese, E.D. (author), Leist, M. (author), Steger-Hartmann, T. (author), van de Water, B. (author)
In 2016, the European Commission launched the EU-ToxRisk research project to develop and promote animal-free approaches in toxicology. The 36 partners of this consortium used in vitro and in silico methods in the context of case studies (CSs). These CSs included both compounds with a highly defined target (e.g. mitochondrial respiratory chain...
article 2020
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Sewell, F. (author), Strupp, C. (author), van der Laan, J.W. (author), Wolf, D.C. (author), Wolterink, G. (author), Woutersen, R. (author), Zvonar, Z. (author), Heusinkveld, H. (author), Braakhuis, H. (author)
Currently the only methods for non-genotoxic carcinogenic hazard assessment accepted by most regulatory authorities are lifetime carcinogenicity studies. However, these involve the use of large numbers of animals and the relevance of their predictive power and results has been scientifically challenged. With increased availability of innovative...
article 2020
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Simons, R. (author), Maire, R. (author)
Recommendations. It is recommended that all aircrew, especially those over the age of 40 years, should be periodically screened for cardiovascular risk using a resting ECG and risk estimating calculators that are representative and appropriate for the population to screen and provide non-fatal and fatal endpoints. Pilots with an elevated CVD...
article 2020
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Steijn, W. (author), van der Beek, D. (author), Groeneweg, J. (author), Jansen, A. (author), Oldenhof, W. (author), Raben, I. (author)
public lecture 2019
Searched for: subject:"Risk%5C+Assessment"
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