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Ligthart, M.E.U. (author), Neerincx, M.A. (author), Hindriks, K.V. (author)In this paper we specify and validate three interaction design patterns for an interactive storytelling experience with an autonomous social robot. The patterns enable the child to make decisions about the story by talking with the robot, reenact parts of the story together with the robot, and recording self-made sound effects. The design...conference paper 2020
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Ruiz-Zapata, A.M. (author), Heinz, A. (author), Kerkhof, M.H. (author), van de Westerlo-van Rijt, C. (author), Schmelzer, C.E.H. (author), Stoop, R. (author), Kluivers, K.B. (author), Oosterwijk, E. (author)Fibroblast to myofibroblast differentiation is a key feature of wound-healing in soft tissues, including the vagina. Vaginal fibroblasts maintain the integrity of the vaginal wall tissues, essential to keep pelvic organs in place and avoid pelvic organ prolapse (POP). The micro-environment of vaginal tissues in POP patients is stiffer and has...article 2020
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Niks, I. (author), van Drongelen, A. (author), de Korte, E. (author)Background: Shift work can be demanding owing to disturbances in the biological and social rhythms. This can cause short-term negative effects in employees, such as increased fatigue and reduced alertness. A potential way to counteract these negative effects is to enhance employees’ recovery from work during working hours. Objective: The aim of...article 2020
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Bar, A. (author), Kieronska-Rudek, A. (author), Proniewski, B. (author), Suraj-Prazmowska, J. (author), Czamara, K. (author), Marczyk, B. (author), Matyjaszczyk-Gwarda, K. (author), Jasztal, A. (author), Kus, E. (author), Majka, Z. (author), Kaczor, A. (author), Kurpinska, A. (author), Walczak, M. (author), Pieterman, E.J. (author), Princen, H.M.G. (author), Chlopicki, S. (author)Background Long-term feeding with a high-fat diet (HFD) induces endothelial dysfunction in mice, but early HFD-induced effects on endothelium have not been well characterized. Methods and Results Using an magnetic resonance imaging-based methodology that allows characterization of endothelial function in vivo, we demonstrated that short-term (2...article 2020
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- Stokman, G. (author), van den Hoek, A.M. (author), Denker Thorbekk, D. (author), Pieterman, E.J. (author), Skovgård Veidal, S. (author), Basta, B. (author), Iruarrizaga-Lejarreta, M. (author), van der Hoorn, J.W. (author), Verschuren, L. (author), Berbée, J.F.P. (author), Rensen, P.C.N. (author), Skjæret, T. (author), Alonso, C. (author), Feigh, M. (author), Kastelein, J.J.P. (author), Friedman, S.L. (author), Princen, H.M.G. (author), Fraser, D.A. (author) article 2020
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Stiebing, C. (author), Jahn, I.J. (author), Schmitt, M. (author), Keijzer, N. (author), Kleemann, R. (author), Kiliaan, A.J. (author), Drexler, W. (author), Leitgeb, R.A. (author), Popp, J. (author)The presence of biomarkers characteristic for Alzheimer's disease in the retina is a controversial topic. Raman spectroscopy offers information on the biochemical composition of tissues. Thus, it could give valuable insight into the diagnostic value of retinal analysis. Within the present study, retinas of a double transgenic mouse model, that...article 2020
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Kozijn, A.E. (author)This thesis aimed to investigate how metabolic overload contributes to the pathophysiology of knee OA. We explored the role of these independent yet intertwined processes using state-of-the-art lipidomic and cellular approaches in mouse models of diet-induced OA. Chapter 2 presents an overview of twelve preclinical studies in which mice received...doctoral thesis 2020
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Krone, T. (author), Boessen, R. (author), Bijlsma, S. (author), van Stokkum, R. (author), Clabbers, N.D.S. (author), Pasman, W.J. (author)Background. N-of-1 designs gain popularity in nutritional research because of the improving technological possibilities, practical applicability and promise of increased accuracy and sensitivity, especially in the field of personalized nutrition. This move asks for a search of applicable statistical methods. Objective. To demonstrate the...article 2020
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Zwamborn, A.P.M. (author), Theil, A. (author)In this report (written in the Dutch language) a non-ionizing radiation hazards analysis has been conducted for the SMART-L air-defense radar planned in Herwijnen, The Netherlands. The expected RF exposure is compared with the reference values from ICNIRP1998 as well as the recently published ICNIRP2020.report 2020
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van den Hoek, A.M. (author), Verschuren, L. (author), Worms, N. (author), van Nieuwkoop, A. (author), de Ruiter, C. (author), Attema, J. (author), Menke, A.L. (author), Caspers, M.P.M. (author), Radhakrishnan, S. (author), Salic, K. (author), Kleemann, R. (author)Non-alcoholic steatohepatitis (NASH) is a fast-growing liver disorder that is associated with an increased incidence of cardiovascular disease and type 2 diabetes. Animal models adequately mimicking this condition are scarce. We herein investigate whether Ldlr−/−. Leiden mice on different high-fat diets represent a suitable NASH model. Ldlr−/−....article 2020
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Yang, C. (author), Hawwash, D. (author), de Baets, B. (author), Bouwman, J. (author), Lachat, C. (author)Robust recommendations for healthy diets and nutrition require careful synthesis of available evidence. Given the increasing volume of research articles generated, the retrieval and synthesis of evidence are increasingly becoming laborious and time-consuming. Information technology could help to reduce workload for humans. To guide supervised...article 2020
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van der Stap, N. (author), Benoist, K. (author), Schutte, K. (author)This paper shows the Netherlands contribution to NATO SET-240 on Exploitation of Longwave Infrared Airborne Hyperspectral Data, that focusses on the detection of soil disturbances, buried objects, and nonburied (surface) objects. Together with other hyperspectral feasibility research on maritime target detection and machine learning. Hyperbolic...conference paper 2020
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Boehrer, N. (author), Gabriel, A. (author), Brandt, A. (author), Uijens, W.R. (author), Kampmeijer, L. (author), van der Stap, N. (author), Schutte, K. (author)With the latest advances in image sensor technology, cameras are able to generate video with tens of megapixels per frame. These high resolution videos streams offer great potential to be used in the surveillance domain. For ground based systems, gigapixel streams are already used with great effect as illustrated by the ICME 2019 crowd counting...conference paper 2020
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- Gerretsen, A. (author), Smelik, R.M. (author), Smith, N. (author), Ly Van, K. (author) conference paper 2020
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Veerman, H.E.T. (author), Schleijpen, H.M.A. (author), Brettschneider, S.A. (author), Amram, R. (author)The observable infrared signature of naval platforms is crucial in determining survivability and is therefore an important issue in warfare. Increased detectability in the EM spectrum leads to higher susceptibility against threats like sea skimming anti-ship missiles. The infrared platform signature is not a fixed quantity but a highly dynamic...conference paper 2020
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de Wit, J.J.M. (author), Gusland, D. (author), Trommel, R.P. (author)The use of drones grows rapidly, recreational and commercial use, as well as malicious use. Following the trend of increasing use, there is an increasing need for radar systems to detect, track and characterize drones. Drone characterization, i.e., extracting information about the payload and intent of a drone, is crucial for the effective...conference paper 2020
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Hardtner, C. (author), Kornemann, J. (author), Krebs, K. (author), Ehlert, C.A. (author), Jander, A. (author), Zou, J. (author), Christopher, (author), Starz, C. (author), Rauterberg, S. (author), Sharipova, D. (author), Dufner, B. (author), Hoppe, N. (author), Dederichs, T.S. (author), Willecke, F. (author), Stachon, p. (author), Heidt, T. (author), Wolf, D. (author), von zur Muhlen, C. (author), Madl, J. (author), Kohl, P. (author), Kaeser, R. (author), Boettler, T. (author), Pieterman, E.J. (author), Princen, H.M.G. (author), Ho-Tin-Noe, B. (author), Swirski, F.K. (author), Robbins, C.S. (author), Bode, C. (author), Zirlik, A. (author), Hilgendorf, I. (author)Statins induce plaque regression characterized by reduced macrophage content in humans, but the underlying mechanisms remain speculative. Studying the translational APOE*3-Leiden.CETP mouse model with a humanized lipoprotein metabolism, we find that systemic cholesterol lowering by oral atorvastatin or dietary restriction inhibits monocyte...article 2020
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Schlunk, F. (author), Fisher, P. (author), Princen, H.M.G. (author), Rex, A. (author), Prinz, V. (author), Foddis, M. (author), Lütjohann, D. (author), Laufs, U. (author), Endres, M. (author)Anti-PCSK9 (proprotein convertase subtilisin/kexin type 9) antibodies lower low-density lipoprotein cholesterol levels and significantly reduce cardiovascular end points.1 Safety concerns were raised as ultra-low levels of low-density lipoprotein cholesterol can be achieved. Low cholesterol levels are associated with an increased rate of...article 2020
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Steen, M. (author), Nauta, J. (author)We view Societal Engagement (SE) as a key element of Responsible Innovation (RI) and want to better understand the advantages and disadvantage of SE, both in theory and in practice. Moreover, we are interested in the role that Research and Technology Organizations (RTOs) might play in bridging the gap between fundamental research in academia and...article 2020
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- Meessen, W.R.M.J. (author) article 2020