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- Stuldreher, I. (author) conference paper 2020
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Bronkhorst, A.W. (author), Marcel-Paul Hasberg, M.P. (author), Meessen, W.R.M.J. (author), van de Weerd, C.E.A. (author)In november 2020 is door het Ministerie van Defensie de Strategische Kennis- en Innovatieagenda (SKIA) voor de periode 2021-2025 uitgebracht. Defensie heeft TNO gevraagd hiervoor input te leveren in de vorm van een update van de strategische duiding van actuele technologie verkenningen zoals die in 2018 is opgesteld ten behoeve van de Defensie...book 2020
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Meessen, W.M.R.J. (author), van Veen, H.J. (author)De geüniformeerde politieman weet niet anders dan dat hij tegenover een anonieme en moeilijk opspoorbare crimineel staat. De geüniformeerde brandweerman heeft al sinds jaar en dag te maken met de onzichtbare pyromaan. En de militair wist zich eeuwenlang geconfronteerd met een herkenbare geüniformeerde vijand. Maar die tijd is voorbij. Private...article 2020
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- Meessen, W.R.M.J. (author), Bekkers, F.F. (author), Torossian, B. (author) article 2020
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- Huijgen, H.W. (author), Janssens, L.A.W. (author) bookPart 2020
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Wilson, B.A.H. (author), Westerhof, T.A.T. (author), Philippens, M.M.G.M. (author)In recent conflicts, a major source of injury for military personnel are Improvised Explosive Devices (IEDs), which generate blast overpressure (BOP), fragments and heat. Personal Protective Equipment (PPE) of dismounted soldiers are primarily tested for protection against bullets, fragments, heat and stabbing using accepted formal standards....conference paper 2020
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- Diran, D.D.D. (author), Hoppe, T. (author), Ubacht, J. (author), Slob, A. (author), Blok, K. (author) article 2020
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van den Bosch, K. (author), Blankendaal, R.A.M. (author), Boonekamp, R. (author), Schoonderwoerd, T.A.J. (author)Simulators and games provide contextually rich environments, enabling learners to experience the relations between actions, events and outcomes. In order to be effective, learning situations need to be tailored to the needs of the individual learner. Virtual characters (or agents) that, in real time, select, adapt, and exhibit the behavior that...conference paper 2020
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Mitropoulou, D. (author), Kalikatzarakis, M. (author), van der Klauw, T. (author), Blokland, A.J. (author), Geertsma, R.D. (author), Bucurenciu, A.M. (author), Dembinskas, D. (author)Adaptability, stealth, damage sustainability, extended range and reliability are key factors to every successful naval mission. The shipbuilding industry conceptualized and deployed a wide variety of power and propulsion architectures over the decades: from mechanical, to electrical and hybrid propulsion. The tendency towards increasingly...conference paper 2020
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Peters, F. (author), den Breejen, E. (author)Future naval operations will increasingly incorporate Maritime Unmanned Systems (MUS). Embedding autonomous MUS in a military organization has its challenges. To overcome these challenges the Royal Netherlands Navy has started the development of a general system of systems architecture, GENIUS. A general outline and functions are described in...conference paper 2020
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Kraaij, W. (author), Verberne, S. (author), Koldijk, S. (author), de Korte, E. (author), van Dantzig, S. (author), Sappelli, M. (author), Shoaib, M. (author), Bosems, S. (author), Achterkamp, R. (author), Bonomi, A. (author), Schavemaker, J. (author), Hulsebosch, B. (author), Wabeke, T. (author), Vollenbroek-Hutten, M. (author), Neerincx, M. (author), Sinderen, M. (author)Recent advances in wearable sensor technology and smartphones enable simple and affordable collection of personal analytics. This paper reflects on the lessons learned in the SWELL project that addressed the design of user-centered ICT applications for self-management of vitality in the domain of knowledge workers. These workers often have a...article 2020
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Pouwer, M.G. (author), Pieterman, E.J. (author), Worms, N. (author), Keijzer, N. (author), Jukema, J.W. (author), Gromada, J. (author), Gusarova, V. (author), Princen, H.M.G. (author)Atherosclerosis-related cardiovascular disease causes nearly 20 million deaths annually. Most patients are treated after plaques develop, so therapies must regress existing lesions. Current therapies reduce plaque volume, but targeting all apoB-containing lipoproteins with intensive combinations that include alirocumab or evinacumab-monoclonal...article 2020
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Pouwer, M.G. (author)The thesis discussed several strategies that may contribute to further CVD risk reduction in the future. We described two novel lipid-lowering strategies, we unraveled (part of) the etiology of the cardiovascular safety issues of TKIs that are used for the treatment of CML, and we investigated the dose effects of PFOA on lipoprotein metabolism....doctoral thesis 2020
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Ligthart, M.E.U. (author), Neerincx, M.A. (author), Hindriks, K.V. (author)In this paper we specify and validate three interaction design patterns for an interactive storytelling experience with an autonomous social robot. The patterns enable the child to make decisions about the story by talking with the robot, reenact parts of the story together with the robot, and recording self-made sound effects. The design...conference paper 2020
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Ruiz-Zapata, A.M. (author), Heinz, A. (author), Kerkhof, M.H. (author), van de Westerlo-van Rijt, C. (author), Schmelzer, C.E.H. (author), Stoop, R. (author), Kluivers, K.B. (author), Oosterwijk, E. (author)Fibroblast to myofibroblast differentiation is a key feature of wound-healing in soft tissues, including the vagina. Vaginal fibroblasts maintain the integrity of the vaginal wall tissues, essential to keep pelvic organs in place and avoid pelvic organ prolapse (POP). The micro-environment of vaginal tissues in POP patients is stiffer and has...article 2020
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Niks, I. (author), van Drongelen, A. (author), de Korte, E. (author)Background: Shift work can be demanding owing to disturbances in the biological and social rhythms. This can cause short-term negative effects in employees, such as increased fatigue and reduced alertness. A potential way to counteract these negative effects is to enhance employees’ recovery from work during working hours. Objective: The aim of...article 2020
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Bar, A. (author), Kieronska-Rudek, A. (author), Proniewski, B. (author), Suraj-Prazmowska, J. (author), Czamara, K. (author), Marczyk, B. (author), Matyjaszczyk-Gwarda, K. (author), Jasztal, A. (author), Kus, E. (author), Majka, Z. (author), Kaczor, A. (author), Kurpinska, A. (author), Walczak, M. (author), Pieterman, E.J. (author), Princen, H.M.G. (author), Chlopicki, S. (author)Background Long-term feeding with a high-fat diet (HFD) induces endothelial dysfunction in mice, but early HFD-induced effects on endothelium have not been well characterized. Methods and Results Using an magnetic resonance imaging-based methodology that allows characterization of endothelial function in vivo, we demonstrated that short-term (2...article 2020
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- Stokman, G. (author), van den Hoek, A.M. (author), Denker Thorbekk, D. (author), Pieterman, E.J. (author), Skovgård Veidal, S. (author), Basta, B. (author), Iruarrizaga-Lejarreta, M. (author), van der Hoorn, J.W. (author), Verschuren, L. (author), Berbée, J.F.P. (author), Rensen, P.C.N. (author), Skjæret, T. (author), Alonso, C. (author), Feigh, M. (author), Kastelein, J.J.P. (author), Friedman, S.L. (author), Princen, H.M.G. (author), Fraser, D.A. (author) article 2020
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Stiebing, C. (author), Jahn, I.J. (author), Schmitt, M. (author), Keijzer, N. (author), Kleemann, R. (author), Kiliaan, A.J. (author), Drexler, W. (author), Leitgeb, R.A. (author), Popp, J. (author)The presence of biomarkers characteristic for Alzheimer's disease in the retina is a controversial topic. Raman spectroscopy offers information on the biochemical composition of tissues. Thus, it could give valuable insight into the diagnostic value of retinal analysis. Within the present study, retinas of a double transgenic mouse model, that...article 2020
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Kozijn, A.E. (author)This thesis aimed to investigate how metabolic overload contributes to the pathophysiology of knee OA. We explored the role of these independent yet intertwined processes using state-of-the-art lipidomic and cellular approaches in mouse models of diet-induced OA. Chapter 2 presents an overview of twelve preclinical studies in which mice received...doctoral thesis 2020