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Malone, K.M. (author), Vissers, J.P.M. (author), Gerrits, B.M. (author), de Wit, A.F.P. (author)Defensie kampt met een tekort aan chauffeurs in bepaalde delen van de logistieke keten. De innovaties op het gebied van truck platooning in de civiele markt kunnen hier een antwoord op bieden. Bij truck platooning zijn vrachtwagens in een konvooi elektronisch aan elkaar gekoppeld, waarbij de voorste truck de snelheid en route bepaalt en de...article 2021
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Westerveld, J.J.L. (author), van den Homberg, M.J.C. (author), Guimarães Nobre, G. (author), van den Berg, D.L.J. (author), Teklesadik, A.D. (author), Stuit, S.M. (author)Food insecurity is a growing concern due to man-made conflicts, climate change, and economic downturns. Forecasting the state of food insecurity is essential to be able to trigger early actions, for example, by humanitarian actors. To measure the actual state of food insecurity, expert and consensus-based approaches and surveys are currently...article 2021
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van den Berg, H. (author), van Hemert, D. (author)Violent extremism is associated with an intricately linked network of variables. Existing psychological models and research tend to either focus on specific forms of violent extremism or take a broad perspective. We propose an abstract model for the path towards violent extremism that allows for specification when needed; the General Needs and...article 2021
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Schouten, D.G.M. (author), Massink, P. (author), Donker, S.F. (author), Neerincx, M.A. (author), Cremers, A.H.M. (author)In this study, we attempt to specify the cognitive support behavior of a previously designed embodied conversational agent coach that provides learning support to low-literates. Three knowledge gaps are identified in the existing work: an incomplete specification of the behaviors that make up ‘support,’ an incomplete specification of how this...article 2021
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Boehrer, N. (author), Nieuwenhuizen, R.P.J. (author), Dijk, J. (author)Long-range horizontal path imaging through atmospheric turbulence is hampered by spatiotemporally randomly varying shifting and blurring of scene points in recorded imagery. Although existing software-based mitigation strategies can produce sharp and stable imagery of static scenes, it remains highly challenging to mitigate turbulence in scenes...article 2021
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Imants, P. (author), Theeuwes, J. (author), Bronkhorst, A.W. (author), Martens, M.H. (author)With the arrival of new technologies more en-route traffic information sources have become available, especially in-car information sources. The aim of this study is to gain more insight into the effect of multiple, and possibly conflicting, sources of information on route choice and driver behaviour. In a driving simulator experiment,...article 2021
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Pak, K. (author), Kooij, D.T.A.M. (author), de Lange, A.H. (author), van den Heuvel, S.G. (author), Veldhoven, M.J.P.M. (author)Organisations are challenged to extend working lives of older workers. However, there is little empirical evidence available on how organisations should do this. This study aims to fill this gap by testing the effect of Human Resource (HR) practices on perceived work ability and the preferred retirement age. Based on the Conversation of...article 2021
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van Hees, S.G.M. (author), Bouwine, C. (author), Blonk, R.W.B. (author), Oomens, S. (author)BACKGROUND: Work participation among employees with common mental disorders (CMDs) is an increasingly important, yet highly complex phenomenon. Given the call for preventing instead of reacting to negative work outcomes, there is a need to understand how employees with CMDs can continue working. OBJECTIVES: 1) to provide insights in applying a...article 2021
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Robroek, S.J. (author), Coenen, P. (author), Oude Hengel, K.M. (author)The potential of workplace health promotion. Unhealthy behaviors (eg, insufficient physical activity, an unhealthy diet, high alcohol intake and smoking) and obesity are risk factors for adverse health outcomes (1,2), productivity loss due to presenteeism or sickness absence (3–6), and early exit from paid employment (7,8). Poor health and...article 2021
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Pieterman, E.J. (author), Princen, H.M.G. (author), Jarke, A. (author), Nilsson, R. (author), Cavallin, A. (author), Bergenholm, L. (author), Henricsson, M. (author), Gopaul, V.S. (author), Agrawal, R. (author), Nissen, S.E. (author), Hurt-Camejo, E. (author)We investigated the effects of chronic oral administration of mineral oil, versus corn oil as control, on intestinal permeability, inflammatory markers, and plasma lipids in APOE*3-Leiden.CETP mice. Mice received mineral oil or corn oil 15 or 30 μL/mouse/day for 16 weeks (15 mice/group). Intestinal permeability was increased with mineral versus...article 2021
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Kentrop, J. (author), Savransky, V. (author), Klaassen, S.D. (author), van Groningen, T. (author), Bohnert, S. (author), Cornelissen, A.S. (author), Cochrane, L. (author), Barry, J. (author), Joosen, M.J.A. (author)Nerve agent exposure is generally treated by an antidote formulation composed of a muscarinic antagonist, atropine sulfate (ATR), and a reactivator of acetylcholinesterase (AChE) such as pralidoxime, obidoxime (OBI), methoxime, trimedoxime or HI-6 and an anticonvulsant. Organophosphates (OPs) irreversibly inhibit AChE, the enzyme responsible for...article 2021
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- Schleijpen, H.M.A. (author), van Binsbergen, S.A. (author), Vosteen, L.L.A. (author), de Groot-Trouw, J.C. (author), Meuken, D. (author), va Eijk, A.M.J. (author) conference paper 2021
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- Paulissen, J.J.M. (author), Meuken, D. (author), van Eijk, A.M.J. (author) conference paper 2021
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Gopaul, V.S. (author), Pieterman, E.J. (author), Princen, H.M.G. (author), Bergenholm, L. (author), Lundborg, E. (author), Cavallin, A. (author), Johansson, M.J. (author), Hawthorne, G. (author), Björkbom, A. (author), Hammarberg, M. (author), Li, X. (author), Jarke, A. (author), Bright, J. (author), Svensson, L. (author), Jansson-Löfmark, R. (author), Abrahamsson, B. (author), Agrawal, R. (author), Hurt-Camejo, E. (author)We investigated the effects of mineral oil on statin pharmacokinetics and inflammatory markers in animal models. A new synthesis strategy produced regioisomers that facilitated the characterization of the main metabolite (M1) of atorvastatin, a lipophilic statin, in C57BL/6NCrl mice. The chemical structure of M1 in mice was confirmed as ortho...article 2021
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- Panoutsopoulos, H. (author), Brewster, C. (author), Fountas, S. (author) conference paper 2021
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Essing, J.A.J. (author), Bossuet, A. (author), Knight, R.J. (author), de Hek, A.P. (author), van Vliet, F.E. (author)This paper describes an integrated S-band phaseshifter driver-amplifier to drive Gallium-Nitride (GaN) based power amplifiers in a phased-array radar transmit chain. This phase driver is implemented in a 0.25μm SiGe BiCMOS process and packaged into a QFN5x5. By using device stacking, the phase driver achieves an output power of more than 32.5dBm...conference paper 2021
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van Bilsen, J.H.M. (author), van den Brink, W. (author), van den Hoek, A.M. (author), Dulos, R. (author), Caspers, M.P.M. (author), Kleeman, R. (author), Wopereis, S. (author), Verschuren, L. (author)Metabolic disorders, such as obesity and type 2 diabetes have a large impact on global health, especially in industrialized countries. Tissue-specific chronic low-grade inflammation is a key contributor to complications in metabolic disorders. To support therapeutic approaches to these complications, it is crucial to gain a deeper understanding...article 2021
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van den Hoek, A.M. (author), Verschuren, L. (author), Caspers, M.P.M. (author), Worms, N. (author), Menke, A.L. (author), Princen, H.M.G. (author)Non-alcoholic steatohepatitis (NASH) is the most rapidly growing liver disease that is nevertheless without approved pharmacological treatment. Despite great effort in developing novel NASH therapeutics, many have failed in clinical trials. This has raised questions on the adequacy of preclinical models. Elafibranor is one of the drugs currently...article 2021
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van Gemert, Y. (author), Kozijn, A.E. (author), Pouwer, M.G. (author), Kruisbergen, N.N.L. (author), van den Bosch, M.H.J. (author), Blom, A.B. (author), Pieterman, E.J. (author), Weinans, H. (author), Stoop, R. (author), Princen, H.M.G. (author), van Lent, P.L.E.M. (author)Objective: High systemic cholesterol levels have been associated with osteoarthritis (OA) development. Therefore, cholesterol lowering by statins has been suggested as a potential treatment for OA. We investigated whether therapeutic high-intensive cholesterol-lowering attenuated OA development in dyslipidemic APOE*3Leiden.CETP mice. Methods:...article 2021
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van Dijk, T. (author), Kater, A. (author), Jansen, M. (author), Dondorp, W.J. (author), Blom, M. (author), Kemp, S. (author), Langeveld, M. (author), Cornel, M.C. (author), van der Pal, S.M. (author), Henneman, L. (author)Neonatal bloodspot screening (NBS) aims to detect treatable disorders in newborns. The number of conditions included in the screening is expanding through technological and therapeutic developments, which can result in health gain for more newborns. NBS expansion, however, also poses healthcare, ethical and societal challenges. This qualitative...article 2021