Searched for: subject:"Reproducibility"
(1 - 20 of 171)

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Kastelein, R.A. (author), Helder-Hoek, L. (author), Cornelisse, S.A. (author), von Benda-Beckmann, A.M. (author), Lam, F.P.A. (author), de Jong, C.A.F. (author), Ketten, D.R. (author)
Noise-induced temporary hearing threshold shift (TTS) was studied in a harbor porpoise exposed to impulsive sounds of scaled-down airguns while both stationary and free-swimming for up to 90 min. In a previous study, ∼4 dB TTS was elicited in this porpoise, but despite 8 dB higher single-shot and cumulative exposure levels (up to 199 dB re 1...
article 2020
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Reisinger, K. (author), Blatz, V. (author), Brinkmann, J. (author), Downs, T.R. (author), Fischer, A. (author), Henkler, F. (author), Hoffmann, S. (author), Krul, C. (author), Liebsch, M. (author), Luch, A. (author), Pirow, R. (author), Reus, A.A. (author), Schulz, M. (author), Pfuhler, S. (author)
Recently revised OECD Testing Guidelines highlight the importance of considering the first site-of-contact when investigating the genotoxic hazard. Thus far, only in vivo approaches are available to address the dermal route of exposure. The 3D Skin Comet and Reconstructed Skin Micronucleus (RSMN) assays intend to close this gap in the in vitro...
article 2018
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van Veldhoven, J. (author), Huijser, T. (author), Nieuwkoop, E. (author), van Putten, M. (author), Koster, N.B. (author), Maas, D.J. (author)
A reproducible measurement of in-band EUV power over time is essential in EUV lithography, e.g. for dose control, for monitoring the transmission of (parts of) the optical path and for detecting changes in EUV source performance. However, all currently available sensors suffer from sensitivity degradation over time due to photon-induced...
conference paper 2016
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van Loon, K. (author), Breteler, M.J.M. (author), van Wolfwinkel, L. (author), Rheineck Leyssius, A.T. (author), Kossen, A.S. (author), Kalkman, C.J. (author), van Zaane, B. (author), Peelen, L.M. (author)
Altered respiratory rate is one of the first symptoms of medical conditions that require timely intervention, e.g., sepsis or opioid-induced respiratory depression. To facilitate continuous respiratory rate monitoring on general hospital wards a contactless, non-invasive, prototype monitor was developed using frequency modulated continuous wave...
article 2016
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Ding, Y. (author), Stahlmecke, B. (author), Jiménez, A.S. (author), Tuinman, I.L. (author), Kaminski, H. (author), Kuhlbusch, T.A.J. (author), van Tongeren, M. (author), Riediker, M. (author)
Different types of aerosolization and deagglomeration testing systems exist for studying the properties of nanomaterial powders and their aerosols. However, results are dependent on the specific methods used. In order to have well-characterized aerosols, we require a better understanding of how system parameters and testing conditions influence...
article 2015
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Teunis, M.A.T. (author), Spiekstra, S.W. (author), Smits, M. (author), Adriaens, E. (author), Eltze, T. (author), Galbiati, V. (author), Krul, C.A.M. (author), Landsiedel, R. (author), Pieters, R. (author), Reinders, J. (author), Roggen, E. (author), Corsini, E. (author), Gibbs, S. (author)
This study describes the international ring trial of the epidermal-equivalent (EE) sensitizer potency assay. This assay does not distinguish a sensitizer from a non-sensitizer, but may classify known skin sensitizers according to their potency. It assesses the chemical concentration resulting in 50% cytotoxicity (EE-EC50) or the 2-fold increase...
article 2014
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Liang, W. (author), Menke, A.L. (author), Driessen, A. (author), Koek, G.H. (author), Lindeman, J.H. (author), Stoop, R. (author), Havekes, L.M. (author), Kleemann., R. (author), van den Hoek, A.M. (author)
Results: The criteria macrovesicular steatosis, microvesicular steatosis, hepatocellular hypertrophy, inflammation and fibrosis were generally applicable to rodent NAFLD. The inter-observer reproducibility (evaluated using the Intraclass Correlation Coefficient) between the ten observers was high for the analysis of macrovesicular steatosis and...
article 2014
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Cushing, R. (author), Koulouzis, S. (author), Strijkers, R.J. (author), Belloum, A.S.Z. (author), Bubak, M. (author)
Reproducibility of Science is considered as one of the main principles of the scientific method, and refers to the ability of an experiment to be accurately reproduced, by third person, in complex experiment every detail matters to ensure the correct reproducibility. In the context of the ICCS 2011, Elsevier organized the executable paper grand...
bookPart 2012
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Yu, L. (author), Li, X. (author), Smith, J. (author), Tierney, S. (author), Sweeney, R. (author), Kjellander, B.K.C. (author), Gelinck, G.H. (author), Anthopoulos, T.D. (author), Stingelin, N. (author)
We present a new soluble pentacene derivative with ethyl substitutions in the 1,13,14,22 backbone positions to modulate the solubility and film forming properties of this material compared to triisopropylsilylethynyl (TIPS) pentacene. This permits reproducible production of molecularly highly ordered structures that feature average transistor...
article 2012
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Jans, M.P. (author), Slootweg, V.C. (author), Boot, C.R. (author), de Morton, N.A. (author), van der Sluis, G. (author), van Meeteren, N.L. (author)
Objective: To examine the reproducibility, construct validity, and unidimensionality of the Dutch translation of the de Morton Mobility Index (DEMMI), a performance-based measure of mobility for older patients. Design: Cross-sectional study. Setting: Rehabilitation center (reproducibility study) and hospital (validity study). Participants:...
article 2011
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van der Meer, J.A. (author), Trap, H.C. (author), Noort, D. (author), van der Schans, M.J. (author), TNO Defensie en Veiligheid (author)
Recently, several methods have been developed to verify exposure to nerve agents. Most of these methods, such as the fluoride reactivation technique and the analysis of inhibited phosphonylated butyrylcholinesterase (BuChE), are based on mass spectrometry. The high specificity of the mass spectrometer might also imply a disadvantage, because the...
article 2010
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Schinkel, J. (author), Fransman, W. (author), Heussen, H. (author), Kromhout, H. (author), Marquart, H. (author), Tielemans, E. (author), TNO Kwaliteit van Leven (author)
Objectives: For regulatory risk assessment under REACH a tiered approach is proposed in which the first tier models should provide a conservative exposure estimate that can discriminate between scenarios which are of concern and those which are not. The Stoffenmanager is mentioned as a first tier approach in the REACH guidance. In an attempt to...
article 2010
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Mariani, B. (author), Hoskovec, C. (author), Rochat, S. (author), Büla, C. (author), Penders, J. (author), Aminian, K. (author), Laboratory of Movement Analysis and Measurements, Ecole Polytechnique Fédérale de Lausanne, -STI-IBI2-LMAM, Station 11/ELH 137, CH-1015 Lausanne, Switzerland Service of Geriatric Medicine, CHUV and CUTR Sylvana, Epalinges, Switzerland Holst Centre/IMEC, High Tech Campus 31, Eindhoven, Netherlands (author)
This study describes the validation of a new wearable system for assessment of 3D spatial parameters of gait. The new method is based on the detection of temporal parameters, coupled to optimized fusion and de-drifted integration of inertial signals. Composed of two wirelesses inertial modules attached on feet, the system provides stride length,...
article 2010
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Daanen, H.A.M. (author), TNO Defensie en Veiligheid (author)
Reactie op: Flouris, et al. Effect of body temperature on cold induced vasodilationa. Eur J Applied Phys 2008;104:491-499. De aurteurs hebben daar weer een reply op geschreven; Flouris AD, Cheung SS (2009) Authors’ response to H. Daanen’s ‘cold-induced vasodilation’ letter. Eur J Appl Physiol 106:317– 319
article 2009
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Hawinkels, L.J.A.C. (author), Verspaget, H.W. (author), van der Reijden, J.J. (author), van der Zon, J.M. (author), Verheijen, J.H. (author), Hommes, D.W. (author), Lamers, C.B.H.W. (author), Sier, C.F.M. (author), TNO Kwaliteit van Leven (author)
Transforming growth factor-β1 (TGF-β1), a cytokine involved in various stages of cancer, is produced as a latent complex and requires processing to become active. We have determined total and active TGF-β1 levels in homogenates of colorectal neoplasia. In contrast to total TGF-β levels, showing a stepwise increase in the mucosa-adenoma-carcinoma...
article 2009
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Slootmaker, S.M. (author), Chin A Paw, M.J.M. (author), Schuit, A.J. (author), van Mechelen, W. (author), Koppes, L.L.J. (author), TNO Kwaliteit van Leven (author)
The purpose of this study was to examine the concurrent validity of the Personal Activity Monitor (PAM) accelerometer relative to the Actigraph accelerometer using oxygen consumption as a reference, and to assess the test-retest reliability of the PAM. Thirty-two fit, normal weight adults (aged 21-54) performed two activities, treadmill walking...
article 2009
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Kong, H. (author), Wang, M. (author), Venema, K. (author), Maathuis, A. (author), van der Heijden, R. (author), van der Greef, J. (author), Xu, G. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)
A high-performance liquid chromatography-high resolution Fourier transform ion cyclotron resonance mass spectrometry (HPLC-FTICR-MS) method was developed to investigate the metabolism of ginsenosides in in vitro models of the gastro-intestinal tract. The metabolites were identified by high-resolution tandem mass spectrometry. Degradation and...
article 2009
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Wang, J. (author), van der Heijden, R. (author), Spijksma, G. (author), Reijmers, T. (author), Wang, M. (author), Xu, G. (author), Hankemeier, T. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)
A matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) method was developed for the high throughput and robust qualitative profiling of alkaloids in Fuzi-the processed lateral roots of the Chinese herbal medicine Aconitum carmichaeli Debx (A. carmichaeli). After optimization, powdered roots - without any further sample...
article 2009
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de Vries, S.I. (author), van Hirtum, H.W.J.E.M. (author), Bakker, I. (author), Hopman-Rock, M. (author), Hirasing, R.A. (author), van Mechelen, W. (author), TNO Kwaliteit van Leven (author)
Purpose: To review recently published studies on the reproducibility, validity, and feasibility of motion sensors used to assess physical activity in healthy children and adolescents (2-18 yr). Methods: On October 2004, a systematic literature search in PubMed, EMBASE, and PsycINFO was performed. This search has been updated on October 2007. In...
article 2009
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van der Werf, M.J. (author), Overkamp, K.M. (author), Muilwijk, B. (author), Koek, M.M. (author), van der Werff van der - Vat, B.J.C. (author), Jellema, R.H. (author), Coulier, L. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)
Metabolomics is an emerging, powerful, functional genomics technology that involves the comparative non-targeted analysis of the complete set of metabolites in an organism. We have set-up a robust quantitative metabolomics platform that allows the analysis of 'snapshot' metabolomes. In this study, we have applied this platform for the...
article 2008
Searched for: subject:"Reproducibility"
(1 - 20 of 171)

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