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McNally, K. (author), Warren, N. (author), Fransman, W. (author), Entink, R.K. (author), Schinkel, J. (author), Van Tongeren, M. (author), Cherrie, J.W. (author), Kromhout, H. (author), Schneider, T. (author), Tielemans, E. (author)This paper describes a Bayesian model for the assessment of inhalation exposures in an occupational setting; the methodology underpins a freely available web-based application for exposure assessment, the Advanced REACH Tool (ART). The ART is a higher tier exposure tool that combines disparate sources of information within a Bayesian statistical...article 2014
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Teunissen, L.P.J. (author), Wang, L.C. (author), Chou, S.N. (author), Huang, C. (author), Jou, G.T. (author), Daanen, H.A.M. (author)Firemen often suffer from heat strain. This study investigated two chest cooling systems for use under a firefighting suit. In nine male subjects, a vest with water soaked cooling pads and a vest with water perfused tubes were compared to a control condition. Subjects performed 30 min walking and 10 min recovery in hot conditions, while...article 2014
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Chen, Y. (author), Sun, A. (author), Wang, M. (author), Zhu, Z. (author), Ouwerkerk, P.B.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Glutelins are the most abundant storage proteins in rice grain and can make up to 80 % of total protein content. The promoter region of GluB-1, one of the glutelin genes in rice, has been intensively used as a model to understand regulation of seed-storage protein accumulation. In this study, we describe a zinc finger gene of the Cys3His1 (CCCH...article 2014
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Hofman, W.J. (author), Bastiaansen, H.J.M. (author)Currently, the fundamentals of a technical infrastructure for a logistics ‘systems-of-systems’ are laid, facilitating improved, more effective and efficient logistics services based on higher levels of self-organization. Through situation awareness with enhanced methods for sharing (real-time) data, logistic stakeholders can improve decision...conference paper 2014
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Colin, M.E.G.D. (author), Binnerts, B. (author), Ainslie, M.A. (author), Benda-Beckmann, A.M. (author), Booth, C. (author), Bouton, N. (author), Harris, C.M. (author), de Jong, C.A.F. (author), Sertlek, H.O. (author), Slabbekoorn, H.W. (author)There is an increasing concern that anthropogenic underwater noise may have a negative impact on marine life. Governmental authorities are introducing regulations to address this problem. The European Commission, for instance, has adopted the Marine Strategy Framework Directive requiring EU Member States to achieve or maintain Good Environmental...conference paper 2014
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Mariman, R. (author), Kremer, S.H.A. (author), Koning, F. (author), Nagelkerken, L. (author)Probiotic bacteria express a wide range of molecular structures that bind to receptors on innate immune cells and mediate health-promoting effects in the host. We have recently demonstrated in a colitis model that favourable effects of the probiotic mixture VSL#3 may in part be due to the suppression of intestinal chemokine expression. To obtain...article 2014
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Saccenti, E. (author), Tenori, L. (author), Verbruggen, P. (author), Timmerman, M.E. (author), Bouwman, J. (author), van der Greef, J. (author), Luchinat, C. (author), Smilde, A.K. (author)Background: Metabolomics has attracted the interest of the medical community for its potential in predicting early derangements from a healthy to a diseased metabolic phenotype. One key issue is the diversity observed in metabolic profiles of different healthy individuals, commonly attributed to the variation of intrinsic (such as (epi)genetic...article 2014
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Vis, D.J. (author), Westerhuis, J.A. (author), Hoefsloot, H.C.J. (author), Roelfsema, F. (author), van der Greef, J. (author), Hendriks, M.M.W.B. (author), Smilde, A.K. (author)Relations among hormone serum concentrations are complex and depend on various factors, including gender, age, body mass index, diurnal rhythms and secretion stochastics. Therefore, endocrine deviations from healthy homeostasis are not easily detected or understood. A generic method is presented for detecting regulatory relations between...article 2014
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de Roo, F. (author), van Beek, J.G. (author)Before the end of 2013, the responsible institutions of the European Union will probably decide on a proposal for a new “Regulation on the sound level of motor vehicles.” It will specify a new type approval test method for noise emission and will give revised limit values for the permissible noise emission per vehicle (sub-)category. The new...article 2014
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Koops, B.J. (author), Hoepman, J.H. (author), Leenes, R. (author)As demonstrated by other papers on this issue, open-source intelligence (OSINT) by state authorities poses challenges for privacy protection and intellectual-property enforcement. A possible strategy to address these challenges is to adapt the design of OSINT tools to embed normative requirements, in particular legal requirements. The experience...article 2013
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Unraveling toxicological mechanisms and predicting toxicity classes with gene dysregulation networksPronk, T.E. (author), van Someren, P. (author), Stierum, R.H. (author), Ezendam, J. (author), Pennings, J.L.A. (author)The use of genes for distinguishing classes of toxicity has become well established. In this paper we combine the reconstruction of a gene dysregulation network (GDN) with a classifier to assign unseen compounds to their appropriate class. Gene pairs in the GDN are dysregulated in the sense that they are linked by a common expression pattern in...article 2013
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Beudeker, D.A. (author), Rink, F.A. (author), Ellemers, N. (author), Blonk, R.W.B. (author)In this research we focus on the self-regulation strategies (promotion and prevention focus) that leaders use to influence followers. We propose that both self-regulation strategies are necessary for leaders in addressing followers. However, each self-regulation strategy is useful to enhance different work behaviors in employees. These...article 2013
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van Meeuwen, L.W. (author), Brand-Gruwel, S. (author), Kirschner, P.A. (author), Bock, J.P.R. (author), Oprins, E.A.P.B. (author), van Merrienboer, J. (author)In the field of aviation, air traffic controllers must be able to adapt to and act upon continuing changes in a highly advanced technological work environment.article 2013
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Lancioni, G.E. (author), O'Reilly, M.F. (author), Singh, N.N. (author), Sigafoos, J. (author), Grumo, G. (author), Pinto, K. (author), Stasolla, F. (author), Signorino, M. (author), Groenewegen, J. (author)We assessed the impact and social rating of an active and a passive music condition implemented with six patients with Alzheimer's disease. In the active condition, the patients used a simple hand response and a microswitch to self-regulate music stimulation inputs. In the passive condition, music stimulation was automatically presented...article 2013
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Nooren, P.A. (author), Leurdijk, A. (author), van Eijk, N. (author)Purpose: Video distribution over the internet leads to heated net-neutrality related debates between network operators and over-the-top application providers. The purpose of this paper is to analyze this debate from a new perspective that takes into account all of the assets that companies try to exploit in the so-called battle for eyeballs in...article 2012
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- Venema, K. (author) article 2012
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van Duuren, J.B.J.H. (author), Wijte, D. (author), Leprince, A. (author), Karge, B. (author), Puchalka, J. (author), Wery, J. (author), Dos Santos, V.A.P.M. (author), Eggink, G. (author), Mars, A.E. (author)Pseudomonas putida KT2440-JD1 was derived from P. putida KT2440 after N-methyl-N'-nitro-N-nitrosoguanidine (NTG)-mutagenesis and exposure to 3-fluorobenzoate (3-FB). The mutant was no longer able to grow using benzoate as a sole carbon source, but co-metabolized benzoate to cis, cis-muconate during growth on glucose, which accumulated in the...article 2011
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van Eunen, K. (author), Rossell, S. (author), Bouwman, J. (author), Westerhoff, H.V. (author), Bakker, B.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Regulation analysis is a methodology that quantifies to what extent a change in the flux through a metabolic pathway is regulated by either gene expression or metabolism. Two extensions to regulation analysis were developed over the past years: (i) the regulation of Vmax can be dissected into the various levels of the gene-expression cascade,...conference paper 2011
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Lu, Y. (author), Boekschoten, M.V. (author), Wopereis, S. (author), Müller, M. (author), Kersten, S. (author)Comparative transcriptomic and metabolomic analysis of fenofibrate and fish oil treatments in mice. Physiol Genomics 43: 1307-1318, 2011. First published September 27, 2011; doi:10.1152/physiolgenomics.00100.2011. Elevated circulating triglycerides, which are considered a risk factor for cardiovascular disease, can be targeted by treatment with...article 2011
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de Vogel, S. (author), Wouters, K.A.D. (author), Gottschalk, R.W.H. (author), van Schooten, F.J. (author), de Goeij, A.F.P.M. (author), de Bruïne, A.P. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), van Engeland, M. (author), Weijenberg, M.P. (author)Dietary methyl donors might influence DNA methylation during carcinogenesis of colorectal cancer (CRC). Among 609 CRC cases and 1,663 subcohort members of the Netherlands Cohort Study on diet and cancer (n = 120,852), we estimated CRC risk according to methyl donor intake across genotypes of folate metabolizing enzymes and methyltransferases....article 2011