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Spook, J.E. (author), Paulussen, T. (author), Kok, G. (author), van Empelen, P. (author)Background: Serious games have the potential to promote health behavior. Because overweight is still a major issue among secondary vocational education students in the Netherlands, this study piloted the effects of “Balance It,” a serious self-regulation game intervention targeting students’ overweight-related behaviors: dietary intake and...article 2016
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Grøtan, T.O. (author), Wærø, I. (author), van der Vorm, J.K.J. (author), van der Beek, F.A. (author), Zuiderwijk, D.C. (author)Operational resilience is critical for organizations to be successful. It allows for continued safe operations under uncertain and shifting circumstances in everyday, emergency and crisis situations. It also allows the organization to progress by learning from how it deals with unexpected situations. Enabling the organization to appreciate,...conference paper 2016
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van Dijk, H.A.L. (author), Spiekman, M.E. (author), Hoes-van Oeffelen, E.C.M. (author)EN ISO 52016-1 presents a coherent set of calculation methods at different levels of detail, for the (sensible) energy needs for the space heating and cooling and (latent) energy needs (de)humidification of a building and/or internal temperatures and heating and/or cooling loads, including the influence from technical buildings systems, control...article 2016
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Plokker, W. (author), van Dijk, H.A.L. (author)The new standard EN ISO 52010-1 provides the common standard climatic data to be used as input by all EPB standards. It builds on EN ISO 15927 (part 1, 2, and 4) and completes a missing link: the calculation of the distribution of solar irradiation and illuminance on a non-horizontal plane based on measured hourly solar radiation data on a...article 2016
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Dourado, F. (author), van den Berg, C. (author), Gama, M. (author)In Europe, commercialization of a "novel food (or ingredient)" or a "food additive," requires food companies to follow a premarket approval scheme set up by the European Commission, a long (3-5 years) and costly (R&D and administrative) process for the food operator to consider beforehand when seeking a competitive edge.Other chapters in this...bookPart 2016
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Ripken, D. (author), van der Wielen, N. (author), van der Meulen, J. (author), Schuurman, T. (author), Witkamp, R.F. (author), Hendriks, H.F.J. (author), Koopmans, S.J. (author)The vagal nerve and gut hormones CCK and GLP-1 play important roles in the control of food intake. However, it is not clear to what extent CCK and GLP-1 increase satiation by stimulating receptors located on abdominal vagal nerve endings or via receptors located elsewhere. This study aimed to further explore the relative contribution of the...article 2015
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Jansen, S. (author), Schmeitz, A.J.C. (author), Akkermans, L. (author)TNO and TML performed a study commissioned by the European Commission regarding what measures on a European level can be taken in relation to the use of tyres to improve road safety. The study considers the use of Winter tyres, tread depth requirements, tyre inflation pressure maintenance and tyre ageing effects and damages. An assessment has...conference paper 2015
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Turner, M.A. (author), Mooij, M.G. (author), Vaes, W.H.J. (author), Windhorst, A.D. (author), Hendrikse, N.H. (author), Knibbe, C.A.J. (author), Körgvee, L.T. (author), Maruszak, W. (author), Grynkiewicz, G. (author), Garner, R.C. (author), Tibbocl, D. (author), Park, B.K. (author), de Wildt, S.N. (author)Important information gaps remain on the efficacy and safety of drugs in children. Pediatric drug development encounters several ethical, practical, and scientifîc chaflenges One barrier to the evaluation of medicines for children is a lack of Innovative methodologies that have been adapted to the needs of chiIdren This article presents our...article 2015
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Liang, W. (author), Verschuren, L. (author), Mulder, P. (author), van der Hoorn, J.W.A. (author), Verheij, J. (author), van Dam, A.D. (author), Boon, M.R. (author), Princen, H.M.G. (author), Havekes, L.M. (author), Kleemann, R. (author), van den Hoek, A.M. (author)BACKGROUND AND PURPOSE: Salsalate (salicylsalicylic acid) is an anti-inflammatory drug that was recently found to exert beneficial metabolic effects on glucose and lipid metabolism. Although its utility in the prevention and management of a wide range of vascular disorders, including type 2 diabetes and metabolic syndrome has been suggested...article 2015
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Detection of the mechanism of immunotoxicity of cyclosporine A in murine in vitro and in vivo modelsSchmeits, P.C.J. (author), Schaap, M.M. (author), Luijten, M. (author), van Someren, E. (author), Boorsma, A. (author), van Loveren, H. (author), Peijnenburg, A.A.C.M. (author), Hendriksen, P.J.M. (author)Transcriptomics in combination with in vitro cell systems is a powerful approach to unravel modes of action of toxicants. An important question is to which extent the modes of action as revealed by transcriptomics depend on cell type, species and study type (in vitro or in vivo). To acquire more insight into this, we assessed the transcriptomic...article 2015
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Derous, D. (author), Kelder, T. (author), van Schothorst, E.M. (author), van Erk, M. (author), Voigt, A. (author), Klaus, S. (author), Keijer, J. (author), Radonjic, M. (author)Health is influenced by interplay of molecular, physiological and environmental factors. To effectively maintain health and prevent disease, health-relevant relations need to be understood at multiple levels of biological complexity. Network-based methods provide a powerful platform for integration and mining of data and knowledge characterizing...article 2015
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van der Tuin, S.J. (author), Kühnast, S. (author), Berbée, J. (author), Verschuren, L. (author), Pieterman, E.J. (author), Havekes, L.M. (author), van der Hoorn, J.W. (author), Rensen, P.C. (author), Jukema, J.W. (author), Princen, H.M. (author), Willems van Dijk, K. (author), Wang, Y. (author)Recently, we showed in APOE*3-Leiden.CETP mice that anacetrapib attenuated atherosclerosis development by reducing (V)LDL-C rather than by raising HDL-C. Here, we investigated the mechanism by which anacetrapib reduces (V)LDL-C and whether this effect was dependent on the inhibition of CETP. APOE*3-Leiden.CETP mice were fed a Western type diet...article 2015
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Nooren, P.A. (author), Koers, W.A. (author), Bangma, M.R. (author), Berkers, F.T.H.M. (author), Boertjes, E.M. (author)The convergence between media, internet and telecoms has brought many new services, devices and distribution models. The availability of multiple routes for delivery of services to end users helps to remove a number of traditional bottlenecks. At the same time, new bottlenecks can appear as the routes bring new technical and business...report 2014
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Ashton, R. (author), de Wever, B. (author), Fuchs, H.W. (author), Gaca, M. (author), Hill, E. (author), Krul, C.A.M. (author), Poth, A. (author), Roggen, E.L. (author)Despite changing attitudes towards animal testing and current legislation to protect experimental animals, the rate of animal experiments seems to have changed little in recent years. On May 15–16, 2013, the In Vitro Testing Industrial Platform (IVTIP) held an open meeting to discuss the state of the art in alternative methods, how companies...article 2014
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Davydenko, I. (author), Ehrler, V. (author), de Ree, D. (author), Lewis, A. (author), Tavasszy, L. (author)Improving the efficiency and sustainability of supply chains is a shared aim of the transport industry, its customers, governments as well as industry organisations. To optimize supply chains and for the identification of best practice, standards for their analysis are needed in order to achieve comparable evaluations. This need for an...article 2014
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Keuken, M.P. (author), Jonkers, S. (author), Verhagen, H.L.M. (author), Perez, L. (author), Truëb, S. (author), Okkerse, W.J. (author), Liu, J. (author), Pan, X.C. (author), Zheng, L. (author), Wang, H. (author), Xu, R. (author), Sabel, C.E. (author)Two traffic scenarios to reduce CO2 emissions from road traffic in two European cities (Basel and Rotterdam) and two Chinese cities (Xi'an and Suzhou) were evaluated in terms of their impact on air quality. The two scenarios, one modelling a reduction of private vehicle kilometres driven by 10% on urban streets and the other modelling the...article 2014
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Grinberg, M. (author), Stöber, R.M. (author), Edlund, K. (author), Rempel, E. (author), Godoy, P. (author), Reif, R. (author), Widera, A. (author), Madjar, K. (author), Schmidt-Heck, W. (author), Marchan, R. (author), Sachinidis, A. (author), Spitkovsky, D. (author), Hescheler, J. (author), Carmo, H. (author), Arbo, M.D. (author), van de Water, B. (author), Wink, S. (author), Vinken, M. (author), Rogiers, V. (author), Escher, S. (author), Hardy, B. (author), Mitic, D. (author), Myatt, G. (author), Waldmann, T. (author), Mardinoglu, A. (author), Damm, G. (author), Seehofer, D. (author), Nüssler, A. (author), Weiss, T.S. (author), Oberemm, A. (author), Lampen, A. (author), Schaap, M.M. (author), Luijten, M. (author), van Steeg, H. (author), Thasler, W.E. (author), Kleinjans, J.C.S. (author), Stierum, R.H. (author), Leist, M. (author), Rahnenführer, J. (author), Hengstler, J.G. (author)A long-term goal of numerous research projects is to identify biomarkers for in vitro systems predicting toxicity in vivo. Often, transcriptomics data are used to identify candidates for further evaluation. However, a systematic directory summarizing key features of chemically influenced genes in human hepatocytes is not yet available. To bridge...article 2014
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Lukovac, S. (author), Belzer, C. (author), Pellis, L. (author), Keijser, B.J. (author), de Vos, W.M. (author), Montijn, R.C. (author), Roeselers, G. (author)The gut microbiota is essential for numerous aspects of human health. However, the underlying mechanisms of many host-microbiota interactions remain unclear. The aim of this study was to characterize effects of the microbiota on host epithelium using a novel ex vivo model based on mouse ileal organoids. We have explored the transcriptional...article 2014
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Gruben, B.S. (author), Zhou, M. (author), Wiebenga, A. (author), Ballering, J. (author), Overkamp, K.M. (author), Punt, P.J. (author), de Vries, R.P. (author)The genome of the filamentous fungus Aspergillus niger is rich in genes encoding pectinases, a broad class of enzymes that have been extensively studied due to their use in industrial applications. The sequencing of the A. niger genome provided more knowledge concerning the individual pectinolytic genes, but little is known about the regulatory...article 2014
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Ybema, J.F. (author), van Dam, K. (author)'Serving with a smile' has generally been associated with negative effects for employee well-being. The present study investigated whether emotional display rules also relate to positive outcomes by distinguishing demands to suppress negative emotional response (negative display rules) from demands to express positive emotions (positive display...article 2014