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van Lint, C.L. (author), van der Boog, P.J.M. (author), Romijn, F.P.H.T.M. (author), Schenk, P.W. (author), van Dijk, S. (author), Rövekamp, T.J.M. (author), Kessler, A. (author), Siekmann, L. (author), Rabelink, T.J. (author), Cobbaert, C.M. (author)Background: The StatSensor® Xpress-i™, a point-of-care system for blood creatinine measurement, offers patients the possibility of self-monitoring creatinine. In this study, the analytical performance of the StatSensor® for both detecting current renal function and monitoring renal (dys)function in kidney transplant patients was examined....article 2015
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van Buuren, S. (author), Ooms, J.C.L. (author), TNO Kwaliteit van Leven (author)This paper presents a method for calculating stage line diagrams, a novel type of reference diagram useful for tracking developmental processes over time. Potential fields of applications include: dentistry (tooth eruption), oncology (tumor grading, cancer staging), virology (HIV infection and disease staging), psychology (stages of cognitive...article 2009
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de Jong, E. (author), Louisse, J. (author), Verwei, M. (author), Blaauboer, B.J. (author), van de Sandt, J.J.M. (author), Woutersen, R.A. (author), Rietjens, I.M.C.M. (author), Piersma, A.H. (author), TNO Kwaliteit van Leven (author)The embryonic stem cell test (EST) has been proposed as an in vitro assay that might reduce animal experimentation in regulatory developmental toxicology. So far, evaluation of the EST was not performed using compounds within distinct chemical classes. Evaluation within a distinct class of chemically related compounds can define the usefulness...article 2009
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- Koek, M.M. (author), Muilwijk, B. (author), van Stee, L.L.P. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author) article 2008
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Koek, M.M. (author), Muilwijk, B. (author), van der Werf, M.J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)An analytical method was set up suitable for the analysis of microbial metabolomes, consisting of an oximation and silylation derivatization reaction and subsequent analysis by gas chromatography coupled to mass spectrometry. Microbial matrixes contain many compounds that potentially interfere with either the derivatization procedure or analysis...article 2006
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Parati, G. (author), Mendis, S. (author), Abegunde, D. (author), Asmar, R. (author), Mieke, S. (author), Murray, A. (author), Shengelia, B. (author), Steenvoorden, G. (author), van Montfrans, G. (author), O'Brien, E. (author), Technisch Physische Dienst TNO - TH (author)This paper, which summarizes the conclusions of a WHO Expert meeting, is aimed at proposing indications to develop technical specifications for an accurate and affordable blood pressure measuring device for office/ clinic use in low resource settings. Blood pressure measuring devices to be used in low resource settings should be accurate,...article 2005
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Bobeldijk, I. (author), Boonzaaijer, G. (author), Spies-Faber, E.J. (author), Vaes, W.H.J. (author), TNO Kwaliteit van Leven (author)Reversed-phase liquid chromatography and detection with atmospheric pressure chemical ionisation tandem mass spectrometry was used for the determination of kava extracts in herbal mixtures. One percent of kava extract can be detected, corresponding to approximately 0.05-0.2 mg/g of the individual kava lactones kavain, dihydrokavain, yangonin,...article 2005
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Fredriks, A.M. (author), van Buuren, S. (author), Fekkes, M. (author), Verloove-Vanhorick, S.P. (author), Wit, J.M. (author)The aim of this study was to present age references for waist circumference (WC), hip circumference (HC), and waist/hip ratio (WHR) in Dutch children. Cross-sectional data were obtained from 14,500 children of Dutch origin in the age range 0-21 years. National references were constructed with the LMS method. This method summarises the...article 2005
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van de Sandt, J.J.M. (author), van Burgsteden, J.A. (author), Cage, S. (author), Carmichael, P.L. (author), Dick, I. (author), Kenyon, S. (author), Korinth, G. (author), Larese, F. (author), Limasset, J.C. (author), Maas, W.J.M. (author), Montomoli, L. (author), Nielsen, J.B. (author), Payan, J.-P. (author), Robinson, E. (author), Sartorelli, P. (author), Schaller, K.H. (author), Wilkinson, S.C. (author), Williams, F.M. (author), TNO Voeding (author)To obtain better insight into the robustness of in vitro percutaneous absorption methodology, the intra- and inter-laboratory variation in this type of study was investigated in 10 European laboratories. To this purpose, the in vitro absorption of three compounds through human skin (9 laboratories) and rat skin (1 laboratory) was determined. The...article 2004
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van Buuren, S. (author), TNO Preventie en Gezondheid (author)Objective. To determine the cut-off values for the body-mass index (BMI) for underweight and serious underweight in children up to 18 years of age based on the Dutch growth standards of 1980, and to determine the prevalence of underweight and serious underweight in the 1997 Dutch growth-study figures. Design. Secondary data analysis. Method. Cut...article 2004
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Prins Maurits Laboratorium TNO (author), van der Schans, M.J. (author), Polhuijs, M. (author), van Dijk, C. (author), Degenhardt, C.E.A.M. (author), Pleijsier, K. (author), Langenberg, J.P. (author), Benschop, H.P. (author)The utility was explored of a new approach to detect retrospectively exposure to nerve agents by means of conversion of the inhibitor moiety bound to the active site of the enzyme BuChE in plasma with fluoride ions into a phosphofluoridate which is subsequently analyzed by means of gas chromatography (GC). This quantifies ≥0.01% inhibition of...article 2004
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Meijer, P. (author), Verbruggen, H.W. (author), de Weerd, B. (author), den Dool, E.J. (author), van Oerle, R. (author), Gaubius Instituut TNO (author)The comparability of test results for protein S between laboratories is hampered by a high inter-laboratory variability. The effect of the use and type of common reference plasma on the inter-laboratory variability of the total and free protein S measurement was evaluated. The results of 10 plasma samples measured against a centrally distributed...article 2002
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Kok, S.J. (author), Arentsen, N.C. (author), Cools, P.J.C.H. (author), Hankemeier, Th. (author), Schoenmakers, P.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The use of a state-of-the-art commercial solvent-elimination interface for liquid chromatography-infrared spectroscopy is discussed from the perspective of quantitative analysis. The effect of eluent flow-rate is investigated with respect to the homogeneity of the deposit and the trace width along the deposition trace. Low flow-rates (50 μl/min...article 2002
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Marquart, H. (author), Maidment, S. (author), Mcclaflin, J.L. (author), Fehrenbacher, M.C. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Dermal exposure assessment and modeling is still in early phases of development. This article presents the results of a workshop organized to harmonize the future needs in this field. Methods for dermal exposure assessment either assess the mass of contaminant that is transferred to the skin, or the transfer of contaminant through the skin....article 2001
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Ollilainen, V. (author), Finglas, P.M. (author), van den Berg, H. (author), de Froidmont-Görtz, I. (author)In 1989, the Community Bureau of Reference started a research program to improve the quality of vitamin analysis in food. To achieve this task, vitamin methodology was evaluated and tested by interlaboratory studies and the preparation of certified reference materials, which will be used for quality control of vitamin measurements. The main...article 2001
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TNO Preventie en Gezondheid (author), Hekkenberg, R.T. (author), Beissner, K. (author), Zeqiri, B. (author), Bezemer, R.A. (author), Hodnett, M. (author)A project has been completed to develop reference methods for the measurement of ultrasonic power with a validated measurement uncertainty of < 7% at power levels of 1 to 20 W over the frequency range 1 to 3 MHz of collimated beams. The project is the result of collaborative research between the Physikalisch-Technische Bundesanstalt, Germany ...article 2001
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van Puymbroeck, M. (author), Kuilman, M.E.M. (author), Maas, R.F.M. (author), Witkamp, R.F. (author), Leyssens, L. (author), van Miert, A.S.J.P.A.M. (author), Hendriks, L. (author), van der Zande, D.J.M. (author), Adriaensens, P. (author), Jacobs, M.-P. (author), Raus, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The metabolism of the illegal growth promoter ethylestrenol (EES) was evaluated in bovine liver cells and subcellular fractions of bovine liver preparations. Incubations with bovine microsomal preparations revealed that EES is extensively biotransformed into norethandrolone (NE), another illegal growth promoter. Furthermore, incubations of...article 1999
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Nieuwenhuizen, W. (author), Gaubius Instituut TNO (author)The term 'D-dimer assay' suggests, that these assays report the concentrations of the end-stage degradation product of crosslinked fibrin. This hardly occurs in patients. Degradation products of crosslinked fibrin rather occur with a wide range of molecular weights, and comprise various numbers of the D-dimer motif. Moreover, the numerical...article 1997
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Mestecky, J. (author), Hamilton, R.G. (author), Magnusson, C.G.M. (author), Jefferis, R. (author), Vaerman, J.P. (author), Goodall, M. (author), de Lange, G.G. (author), Moro, I. (author), Aucouturier, P. (author), Radl, J. (author), Cambiaso, C. (author), Silvain, C. (author), Preud'homme, J.L. (author), Kusama, K. (author), Carlone, G.M. (author), Biewenga, J. (author), Kobayashi, K. (author), Skvaril, F. (author), Reimer, C.B. (author), Gaubius Instituut TNO (author)51 monoclonal antibodies (McAb) with putative specificity for human IgA, the IgA subclasses, Am allotypes or secretory component (SC) were evaluated for immunoreactivity and specificity by nine laboratories employing immunodiffusion, agglutination, immunohistological assays, immunoblotting and direct binding and competitive inhibition enzyme...article 1996
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Fay, R.M. (author), Feron, V.J. (author), TNO Voeding (author)Regarding risk evaluation of complex mixtures, the Working Group discussed the following topics: evaluation of the mixture as a whole, fractionation of the mixture, identification of the 'top ten' chemicals, and composite standards. It was concluded that no standard methodology for hazard identification and risk assessment of complex mixtures...article 1996
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