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Rovida, C. (author), Escher, S.E. (author), Herzler, M. (author), Bennekou, S.H. (author), Kamp, H. (author), Kroese, D.E. (author), Maslankiewicz, L. (author), Moné, M.J. (author), Patlewicz, G. (author), Sipes, N. (author), van Aerts, L. (author), White, A. (author), Yamada, T. (author), van de Water, B. (author)The use of new approach methodologies (NAMs) in support of read-across (RAx) approaches for regulatory purposes is a main goal of the EU-ToxRisk project. To bring this forward, EU-ToxRisk partners convened a workshop in close collaboration with regulatory representatives from key organizations including European regulatory agencies, such as the...article 2021
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Franken, R. (author), Shandilya, N. (author), Marquart, H. (author), McNally, K. (author), Fransman, W. (author)Measured data are generally preferred to modelled estimates of exposure. Grouping and read-across is already widely used and accepted approach in toxicology, but an appropriate approach and guidance on how to use existing exposure measurement data on one substance and work situation for another substance and/or work situation is currently not...article 2020
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Zulqarnain, M. (author), Stanzione, S. (author), van der Steen, J.L.P.J. (author), Gelinck, G.H. (author), Myny, K. (author), Cantatore, E. (author)This work presents a low power ECG interface for wearable applications, based on unipolar a-IGZO TFTs manufactured on a flexible substrate. The interface consists of a cascaded diode-connected load preamplifier followed by a reset integrator, which is used to convert the voltage signal to a pulse-width modulated (PWM) representation. The output...conference paper 2019
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Ding, D. (author), Neerincx, M.A. (author), Brinkman, W.P. (author)Introduction: Inner voice is estimated to occur at least a quarter of people’s conscious waking life. Much research work asserts that inner voice plays various important roles in cognitive functions, such as self-regulation, self-reflection, and so on. Virtual cognitions are a stream of simulated thoughts people can hear while emerged in a...article 2018
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Zulqarnain, M. (author), Stanzione, S. (author), van der Steen, J.L.P.J. (author), Gelinck, G.H. (author), Myny, K. (author), Abdinia, S. (author), Cantatore, E. (author)This paper presents a 52 μW heart-rate measurement interface for wearable applications, fabricated on a flexible foil with a-IGZO TFTs. The interface consists of a cascaded diode-connected load preamplifier with a gain of 22 dB in 3 kHz bandwidth. The output is provided as a binary PWM waveform, which can be sent to a reader device using...conference paper 2018
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Hoepman, J.H. (author)A well studied privacy problem in the area of smart grids is the question of how to aggregate the sum of a set of smart meter readings in a privacy friendly manner, i.e., in such a way that individual meter readings are not revealed to the adversary. Much less well studied is how to deal with arbitrary meter crashes during such aggregation...conference paper 2017
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Brouwer, D. (author), Boessen, R. (author), van Duuren-Stuurman, B. (author), Bard, D. (author), Moehlmann, C. (author), Bekker, C. (author), Fransman, W. (author), Entink, R.K. (author)Tiered or stepwise approaches to assess occupational exposure to nano-objects, and their agglomerates and aggregates have been proposed, which require decision rules (DRs) to move to a next tier, or terminate the assessment. In a desk study the performance of a number of DRs based on the evaluation of results from direct reading instruments was...article 2016
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Fransman, W. (author), Bekker, C. (author), Tromp, P. (author), Duis, W.B. (author)Increasing production and applications of manufactured nano objects (MNOs) have become a source for human exposure and therefore raise concerns and questions about the possible health effects. In this study, the potential release of nano objects, their agglomerates, and aggregates (NOAA) as a result of sanding of hardwood treated with MNOs...article 2016
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Zhu, H. (author), Bouhifd, M. (author), Donley, E. (author), Egnash, L. (author), Kleinstreuer, N. (author), Kroese, E.D. (author), Liu, Z. (author), Luechtefeld, T. (author), Palmer, J. (author), Pamies, D. (author), Shen, J. (author), Strauss, V. (author), Wu, S. (author), Hartung, T. (author)Read-across, i.e., filling toxicological data gaps by relating to similar chemicals for which test data are available, is usually done based on chemical similarity. Besides structure and physico-chemical properties, biological similarity based on biological data adds extra strength to this process. In the simplest case, chemically similar...article 2016
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van Erp, J.B.F. (author), Hogervorst, M.A. (author), van der Werf, Y.D. (author)Ebooks of the future may respond to the emotional experience of the reader. (Neuro-) physiological measures could capture a reader's emotional state and use this to enhance the reading experience by adding matching sounds or to change the storyline therewith creating a hybrid art form in between literature and gaming. We describe the theoretical...article 2016
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Ball, N. (author), Cronin, M.T.D. (author), Shen, J. (author), Blackburn, K. (author), Booth, E.D. (author), Bouhifd, M. (author), Donley, E. (author), Egnash, L. (author), Hastings, C. (author), Juberg, D.R. (author), Kleensang, A. (author), Kleinstreuer, N. (author), Kroese, E.D. (author), Lee, A.C. (author), Luechtefeld, T. (author), Maertens, A. (author), Marty, S. (author), Naciff, J.M. (author), Palmer, J. (author), Pamies, D. (author), Penman, M. (author), Richarz, A.N. (author), Russo, D.P. (author), Stuard, S.B. (author), Patlewicz, G. (author), van Ravenzwaay, B. (author), Wu, S. (author), Zhu, H. (author), Hartung, T. (author)Grouping of substances and utilizing read-across of data within those groups represents an important data gap filling technique for chemical safety assessments. Categories/analogue groups are typically developed based on structural similarity and, increasingly often, also on mechanistic (biological) similarity. While read-across can play a key...article 2016
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Hiemstra-van Mastrigt, S. (author), Kamp, I. (author), van Veen, S.A.T. (author), Vink, P. (author), Bosch, T. (author)New technologies have led to an increasingly sedentary lifestyle. Sedentary behaviour is characterised by physical inactivity and is associated with several health risks. This excessive sitting does not only take place in the office or at home, but also during daily commute. Therefore, BMW AG developed an active seating system for the back seat...article 2015
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Van der Burg, B. (author), Wedebye, E.B. (author), Dietrich, D.R. (author), Jaworska, J. (author), Mangelsdorf, I. (author), Paune, E. (author), Schwarz, M. (author), Piersma, A.H. (author), Kroese, E.D. (author)There is a great need for rapid testing strategies for reproductive toxicity testing, avoiding animal use.The EU Framework program 7 project ChemScreen aimed to fill this gap in a pragmatic manner prefer-ably using validated existing tools and place them in an innovative alternative testing strategy. In ourapproach we combined knowledge on...article 2015
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Brouwer, A.M. (author), Hogervorst, M.A. (author), Reuderink, B. (author), van der Werf, Y. (author), van der Erp, J.B.F. (author)We are interested in monitoring an individual’s emotions during the reading of a novel. While physiological responses to experimentally induced emotions are often small and inconsistent, being engaged in a novel may elicit relatively strong responses. We analyzed EEG, ECG, skin conductance and respiration of 57 readers reading a complete, yet to...article 2015
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Kroese, E.D. (author), Bosgra, S. (author), Buist, H.E. (author), Lewin, G. (author), van der Linden, S.C. (author), Man, H.Y. (author), Piersma, A.H. (author), Rorije, E. (author), Schulpen, S.H.W. (author), Schwarz, M. (author), Uibel, F. (author), van Vugt-Lussenburg, B.M.A. (author), Wolterbeek, A.P.M. (author), van der Burg, B. (author)Previously we showed a battery consisting of CALUX transcriptional activation assays, the ReProGlo assay, and the embryonic stem cell test, and zebrafish embryotoxicity assay as 'apical' tests to correctly predict developmental toxicity for 11 out of 12 compounds, and to explain the one false negative [7]. Here we report on applying this battery...article 2015
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Myny, K. (author), Smout, S. (author), Rockelé, M. (author), Bhoolokam, A. (author), Ke, T.H. (author), Steudel, S. (author), Cobb, B. (author), Gulati, A. (author), Rodriguez, F.G. (author), Obata, K. (author), Marinkovic, M. (author), Pham, D.V. (author), Hoppe, A. (author), Gelinck, G.H. (author), Genoe, J. (author), Dehaene, W. (author), Heremans, P. (author)The Internet of Things is driving extensive efforts to develop intelligent everyday objects. This requires seamless integration of relatively simple electronics, for example through ‘stick-on’ electronics labels. We believe the future evolution of this technology will be governed by Wright’s Law, which was first proposed in 1936 and states that...article 2014
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Patlewicz, G. (author), Ball, N. (author), Becker, R.A. (author), Booth, E.D. (author), Cronin, M.T.D. (author), Kroese, D. (author), Steup, D. (author), van Ravenzwaay, B. (author), Hartung, T. (author)Read-across is a data gap filling technique used within category and analogue approaches. It has been utilized as an alternative approach to address information requirements under various past and present regulatory programs such as the OECD High Production Volume Programme as well as the EU's Registration, Evaluation, Authorisation and...article 2014
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Commissaris, D.A.C.M. (author), Könemann, R. (author), Hiemstra-van Mastrigt, S. (author), Burford, E.M. (author), Botter, J. (author), Douwes, M. (author), Ellegast, R.P. (author)Sedentary work entails health risks. Dynamic (or active) workstations, at which computer tasks can be combined with physical activity, may reduce the risks of sedentary behaviour. The aim of this study was to evaluate short term task performance while working on three dynamic workstations: a treadmill, an elliptical trainer, a bicycle ergometer...article 2014
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Myny, K. (author), Smout, S. (author), Rockelé, M. (author), Bhoolokam, A. (author), Ke, T.H. (author), Steudel, S. (author), Obata, K. (author), Marinkovic, M. (author), Pham, D.V. (author), Hoppe, A. (author), Gulati, A. (author), Rodriguez, F.G. (author), Cobb, B. (author), Gelinck, G.H. (author), Genoe, J. (author), Dehaene, W. (author), Heremans, P. (author)We present an 8b general-purpose microprocessor realized in a hybrid oxide-organic complementary thin-film technology. The n-type transistors are based on a solution-processed n-type metal-oxide semiconductor, and the p-type transistors use an organic semiconductor. As compared to previous work utilizing unipolar logic gates [1], the higher...conference paper 2014
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Benoist, K.W. (author), Schleijpen, R.M.A. (author)A simple model has been developed and implemented in Matlab code, predicting the over-exposed pixel area of cameras caused by laser dazzling. Inputs of this model are the laser irradiance on the front optics of the camera, the Point Spread Function (PSF) of the used optics, the integration time of the camera, and camera sensor specifications...conference paper 2014