Searched for: subject%3A%22Rats%252C%255C%2BInbred%255C%2BStrains%22
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Heijne, W.H.M. (author), Slitt, A.L. (author), van Bladeren, P.J. (author), Groten, J.P. (author), Klaassen, C.D. (author), Stierum, R.H. (author), van Ommen, B. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Rats were exposed to three levels of bromobenzene, sampled at 6, 24, and 48 h, and liver gene expression profiles were determined to identify dose and time-related changes. Expression of many genes changed transiently, and dependent on the dose. Few changes were identified after 6 h, but many genes were differentially expressed after 24 h, while...
article 2004
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Cappaert, N.L.M. (author), Klis, S.F.L. (author), Muijser, H. (author), Kulig, B.M. (author), Ravensberg, L.C. (author), Smoorenburg, G.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The present study was designed to compare the ototoxic effects of volatile ethyl benzene in guinea pigs and rats. Rats showed deteriorated auditory thresholds in the mid-frequency range, based on electrocochleography, after 550-ppm ethyl benzene (8 h/day, 5 days). Outer hair cell (OHC) loss was found in the corresponding cochlear regions. In...
article 2002
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TNO Preventie en Gezondheid (author), Richters, C.D. (author), Mayen, I. (author), Havenith, C.E.G. (author), Beelen, R.H.J. (author), Kamperdijk, E.W.A. (author)
Dendritic cells (DC) are the most potent antigen-presenting cells and are therefore useful to induce immune responses against tumor cells in patients. DC can be generated in vitro from monocytes using GM-CSF and IL-4, the so-called monocyte-derived DC (MoDC). To achieve antitumor responses, MoDC must be able to migrate to the draining lymph...
article 2002
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Cappaert, N.L.M. (author), Klis, S.F.L. (author), Muijser, H. (author), Kulig, B.M. (author), Smoorenburg, G.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The effects on hearing of simultaneous exposure to the ototoxic organic solvent ethyl benzene and broad-band noise were evaluated in rats. The effects of three ethyl benzene concentrations (0, 300 or 400 ppm) and three noise levels (95 or 105 dBlin SPL or background noise at 65 dBlin SPL) and all their combinations were investigated for a 5 day...
article 2001
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Geutskens, S.B. (author), van der Eb, M.M. (author), Plomp, A.C. (author), Jonges, L.E. (author), Cramer, S.J. (author), Ensink, N.G. (author), Kuppen, P.J.K. (author), Hoeben, R.C. (author)
The host-immune response against adenoviruses forms a major obstacle for their use as gene therapy vectors for treatment of genetic defects. None the less, they are the preferred vectors for in vivo gene transfer in experimental gene therapy protocols for cancer. In this article we demonstrate the antitumor efficacy of adenovirus-mediated...
article 2000
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Arts, J.H.E. (author), Dröge, S.C.M. (author), Bloksma, N. (author), Kuper, C.F. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
Five rat strains were compared for their performance in the local lymph node assay (LLNA) a promising test system for the identification of the skin-sensitizing potential of chemicals in the mouse. The contact sensitizer 2,4-dinitrochlorobenzene (DNCB) and the contact and respiratory sensitizer trimellitic anhydride (TMA) were used as model...
article 1996
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Seifert, W.F. (author), Bosma, A. (author), Brouwer, A. (author), Hendriks, H.F.J. (author), Roholl, P.J.M. (author), van Leeuwen, R.E.W. (author), de Thiel van-Ruiter, G.C.F. (author), Seifert-Bock, I. (author), Knook, D.L. (author), TNO Preventie en Gezondheid (author)
Earlier studies have shown that retinoid administration suppresses the generation of hepatic fibrosis and stimulates its regression in normal (i.e., vitamin A-sufficient) carbon tetrachloride-treated rats. This study focuses on the possible role of a marginal or deficient vitamin A status on carbon tetrachloride-induced fibrosis. This...
article 1994
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van den Berg, K.J. (author), Gramsbergen, J.B.P. (author), Medisch Biologisch Laboratorium TNO Centraal Instituut voor Voedingsonderzoek TNO (author)
Chemicals/CAS: calcium, 7440-70-2; kainic acid, 487-79-6; Biological Markers; Calcium, 7440-70-2; Glial Fibrillary Acidic Protein; Kainic Acid, 487-79-6; Neurotoxins
article 1993
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Instituut CIVO-Toxicologie en Voeding TNO (author), Rutten, A.A.J.J.L. (author), Falke, H.E. (author), Catsburg, J.F. (author), Wortelboer, H.M. (author), Blaauboer, B.J. (author), Doorn, L. (author), van Leeuwen, F.X.R. (author), Theelen, R. (author), Rietjens, I.M.C.M. (author)
Assay conditions and results of cytochrome P-450 dependent 7-ethoxyresorufin (ER) and 7-pentoxyresorufin (PR) O-dealkylation (OD) by rat liver microsomes were compared by four laboratories in the Netherlands. Microsomal mixtures were prepared from control, 3-methylcholanthrene and phenobarbital pretreated animals, resulting in different levels...
article 1992
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Instituut CIVO-Toxicologie en Voeding TNO (author), Appel, M.J. (author), Meijers, M. (author), van Garderen-Hoetmer, A. (author), Lamers, C.B.H.W. (author), Rovati, L.C. (author), Sprij-Mooij, D. (author), Jansen, J.B.M.J. (author), Woutersen, R.A. (author)
The role of cholecystokinin in dietary fat-promoted pancreatic carcinogenesis was investigated in azaserine-treated rats, using lorglumide, a highly specific cholecystokinin-receptor antagonist. The animals were killed 8 months after the start of treatment. Cholecystokinin, but not dietary unsaturated fat, increased pancreatic weight. Rats...
article 1992
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Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author), Kuiper, J. (author), Rijken, D.C. (author), Munk, G.A. (author), van Berkel, T.J. (author)
The plasma clearance and the interaction of high (HMW) and low (LMW) molecular weight single-chain urokinase-type plasminogen activator (scu-PA) with rat liver cells was determined. 125I-Labeled HMW- and LMW-scu-PA were rapidly cleared from plasma with a half-life of 0.45 min and a maximal liver uptake of 55% of the injected dose. Liver uptake...
article 1992
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Philippens, I.H.C.H.M. (author), Melchers, B.P.C. (author), de Groot, D.M.G. (author), Wolthuis, O.L. (author)
It is known that rats poisoned with near-lethal doses of pinacolyl methylphosphonofluoridate (soman) develop brain lesions, particularly when convulsions are induced. When rats were intoxicated with a LD50 of soman and treated immediately thereafter with a combination of low doses of atropine and diazepam (LOW AS/DZ treatment), large decrements...
article 1992
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Bosma, A. (author), Seifert, W.F. (author), Wilson, J.H.P. (author), Roholl, P.J.M. (author), Brouwer, A. (author), Knook, D.L. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author)
Rats of two strains (BN/BiRij and WAG/Rij) were fed the ethanol-containing Lieber-De Carli liquid diet supplemented with high amounts of vitamin A for 16 months. In contrast to Lieber and co-workers, who showed liver fibrosis developing within 9 months on the same diet in Sprague-Dawley rats, we were unable to demonstrate a histological and...
article 1991
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Wolthuis, O.L. (author), Philippens, I.H.C.H.M. (author), Vanwersch, R.A.P. (author), Medisch Biologisch Laboratorium TNO (author), MBL (author)
Several earlier studies showed that, in contrast with DFP, repeated injections with soman did not lead to behavioral tolerance in rats. The reason for the difference between the effects of these two organophosphate cholinesterase inhibitors was not clear and a neurophysiological approach was undertaken. Four experiments (A, B, C and D) were...
article 1991
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van den Berg, K.J. (author), van Raaij, J.A.G.M. (author), Bragt, P.C. (author), Notten, W.R.F. (author), Medisch Biologisch Laboratorium TNO (author)
Previous results in experimental systems have suggested that hydroxylated PCBs may decrease thyroid hormone levels through associative interaction with transthyretin. In the present paper it was investigated whether this property was also shared by various industrial chemicals, mainly pesticides. In total, 65 compounds from 12 chemical groups...
article 1991
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Padro, T. (author), van den Hoogen, C.M. (author), Emeis, J.J. (author), Gaubius Instituut TNO (author)
Plasmin inhibition by rat tissue extracts were compared with rat plasma plasmin inhibition. Nine different tissues were extracted with an acid acetate-buffer (lung, heart, brain, adrenal, aorta, skeletal muscle, spleen and liver) or with KSCN-buffer (kidney), and antiplasmin activity was evaluated by a spectrophotometric method. All tissue...
article 1991
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van Nesselrooij, J.H.J. (author), Bruijntjes, J.P. (author), Garderen van-Hoetmer, A. (author), Tillapaugh-Fay, G.M. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Estrogen-induced pituitary lesions in rats were studied in time-sequence experiments using magnetic resonance imaging (MRI), hormone determinations and light microscopy. The main purpose of the study was to evaluate the usefulness of MRI in comparison with conventional biochemical and histopathological methods for detecting the pituitary lesions...
article 1991
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Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author), Gijbels, M.J.J. (author), Visser, J.W.M. (author), Solleveld, H.A. (author), Broerse, J.J. (author), Zurcher, C. (author)
Archival paraffin embedded material was used to examine whether additional quantitative criteria would be helpful to discriminate between histologically benign and malignant rat mammary tumours. To this end nuclear DNA content expressed as DNA ploidy index (DI) was measured using flow cytometry (FCM). A total of 63 benign and malignant mammary...
article 1991
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Instituut CIVO-Toxicologie en Voeding TNO (author), Groten, J.P. (author), Sinkeldam, E.J. (author), Luten, J.B. (author), van Bladeren, P.J. (author)
The distribution of cadmium was examined in rats fed diets containing either cadmium-metallothionein (CdMt) or cadmium chloride (CdCl2) for 4 weeks. The test diets contained 3, 10, or 30 mg Cd/kg diet (3, 10, or 30 ppm) as CdMt or 30 mg Cd/kg diet (30 ppm) as CdCl2. A second study was performed to establish the Cd content in liver and kidneys...
article 1991
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Padró, T. (author), van den Hoogen, C.M. (author), Emeis, J.J. (author), Gaubius Instituut TNO (author)
Tissue-type plasminogen activator (PA) activity and antigen was measured in nine different tissues from healthy rats (brain, lung, heart, liver, spleen, kidney, adrenal, aorta and skeletal muscle). After extraction in a KSCN buffer (for kidney) or in an acid acetate buffer (for all other tissues), total PA activity was determined by an improved...
article 1990
Searched for: subject%3A%22Rats%252C%255C%2BInbred%255C%2BStrains%22
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