Searched for: subject:"Rat%5C+strain"
(1 - 15 of 15)
document
Heijne, W.H.M. (author), Jonker, D. (author), Stierum, R.H. (author), van Ommen, B. (author), Groten, J.P. (author), TNO Kwaliteit van Leven (author)
Benzene is an industrial chemical, component of automobile exhaust and cigarette smoke. After hepatic bioactivation benzene induces bone marrow, blood and hepatic toxicity. Using a toxicogenomics approach this study analysed the effects of benzene at three dose levels on gene expression in the liver after 28 daily doses. NMR based metabolomics...
article 2005
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Verhoeckx, K.C.M. (author), Doornbos, R.P. (author), van der Greef, J. (author), Witkamp, R.F. (author), Rodenburg, R.J.T. (author), TNO Kwaliteit van Leven (author)
In this study the anti-inflammatory properties of zilpaterol, a β2-adrenergic receptor (AR) agonist specifically developed as a growth promoter in cattle were investigated. Although zilpaterol has a different structure compared with the β2-AR agonists known to date, it was noted that it was able to bind to both the β2-AR (K i = 1.1 × 10-6) and...
article 2005
document
Knippels, L.M.J. (author), van Wijk, F. (author), Penninks, A.H. (author), TNO Voeding (author)
Purpose of review This review summarizes selected articles on animal models of food allergy published in 2003. The research areas that are covered include mechanistic studies, the search for new therapies, as well as screening models for hazard identification of potential allergens. Recent findings Novel treatment options of both prevention and...
article 2004
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van Ommen, B. (author), de Bie, A.T.H.J. (author), Bär, A. (author), TNO Voeding (author)
The absorption, disposition, metabolism, and excretion of uniformly 14C-labeled α-cyclodextrin (14C-α-CD) was examined in four separate experiments with Wistar rats. In Experiment 1, 14C-α-CD (25μCi, 50mg/kg bw) was administered intravenously to four male and four female conventional rats. In Experiment 2, 14C-α-CD (25μCi, 200mg/kg bw) was given...
article 2004
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Waalkens-Berendsen, D.H. (author), Bär, A. (author), TNO Voeding (author)
The embryotoxicity/teratogenicity of α-cyclodextrin (α-CD) was examined in Wistar Crl:(WI)WU BR rats. α-CD was fed at dietary concentrations of 0, 1.5, 5, 10, or 20% to groups of 25 pregnant female rats from day 0 to 21 of gestation. An additional group received a diet with 20% lactose. The additions to the diet of α-CD and lactose were made at...
article 2004
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Bellou, A. (author), Saint-Laudy, J. (author), Knippels, L. (author), Montémont, C. (author), Vauthier, E. (author), Gerard, P. (author), Pellegrom, H. (author), Koerkamp, E.K. (author), Lesesve, J.F. (author), Guéant, J.L. (author), Lambert, H. (author), Mallié, J.P. (author), TNO Voeding (author)
Anaphylactic shock is an immunoglobulin E (IgE)-dependent hypersensitivity. Biological tests like leucocyte histamine release (LHR) and human basophil activation (HBA), frequently used in human allergy, reflect both the amount of IgE fixed on cells and the cellular reactivity. To assess whether serum-specific IgE from Brown Norway (BN) rats...
article 2003
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Knippels, L.M.J. (author), Penninks, A.H. (author), TNO Voeding (author)
The need for widely accepted and validated animal models to test the potential allergenicity and potency of novel (biotechnology-derived) proteins has become an important issue for their safety evaluation.In this article, we summarize the results of the development of an oral sensitization protocol for food proteins in the rat. Young Brown...
article 2003
document
Arts, J.H.E. (author), de Koning, M.W. (author), Bloksma, N. (author), Kuper, C.F. (author), TNO Voeding (author)
Several acid anhydrides are known for their sensitizing and irritative properties. Since both irritation and respiratory allergy can cause changes of lung function, proper testing of allergen-dependent effects on the respiratory tract requires knowledge of the respiratory irritant effects. To study the latter effects, groups of female Brown...
article 2001
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Geutskens, S.B. (author), van der Eb, M.M. (author), Plomp, A.C. (author), Jonges, L.E. (author), Cramer, S.J. (author), Ensink, N.G. (author), Kuppen, P.J.K. (author), Hoeben, R.C. (author)
The host-immune response against adenoviruses forms a major obstacle for their use as gene therapy vectors for treatment of genetic defects. None the less, they are the preferred vectors for in vivo gene transfer in experimental gene therapy protocols for cancer. In this article we demonstrate the antitumor efficacy of adenovirus-mediated...
article 2000
document
van Stipdonk, M.J.B. (author), Willems, A.A. (author), Plomp, A.C. (author), van Noort, J.M. (author), Boog, C.J.P. (author), TNO Preventie en Gezondheid (author)
The myelin-associated protein, αB-crystallin, is considered a candidate autoantigen in multiple sclerosis (MS). In the present study, we examined the potential of αB-crystallin to induce experimental autoimmune encephalomyelitis (EAE) in Lewis rats. Attempts to induce EAE with either bovine, rat or murine αB-crystallin or αB-crystallin peptides...
article 2000
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de Vries, A.C.J. (author), Vermeer, M.A. (author), Bredman, J.J. (author), Bar, P.R. (author), Cohen, L.H. (author), Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
The influence of the 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors pravastatin and simvastatin on lens cholesterol metabolism was investigated in the rat. Short-term organ culture experiments with explanted lenses from 21-day-old Wistar rats showed that simvastatin was at least 35 times more effective than pravastatin in...
article 1993
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van Rongen, E. (author), Tan, C. (author), Zurcher, C. (author), Radiobiologisch Instituut TNO (author)
article 1986
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Varekamp, A.E. (author), de Vries, A.J. (author), Hagenbeek, A. (author), Radiobiologisch Instituut TNO (author)
Interstitial pneumonitis (IP) is one of the major complications after allogeneic bone marrow transplantation (incidence: 30 to 50%, fatality rate: 50 to 60%). Cytomegalovirus is associated with 60% of the cases. When no infectious agent can be detected, it is classified as idiopathic IP (IIP). Factors related to IIP are: remission induction...
article 1986
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Hermens, A.F. (author), Korving, R. (author), de Leeuw, A.M. (author), van den Berg, K.J. (author), Radiobiologisch Instituut TNO (author)
article 1986
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Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)
The effects of etiracetam, a structural analogue or piracetam, were investigated in rats on Y-maze discrimination acquisition, on open field behavior, on one-trial passive avoidance learning and on shuttlebox acquisition and extinction. The results indicate that this drug significantly enhances acquisition and may improve retention without...
article 1981
Searched for: subject:"Rat%5C+strain"
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