Searched for: subject%3A%22RAPID%255C%2B%255C-%255C%2BRisk%255C%2BAssessment%255C%2BProducts%255C%2Bin%255C%2BDevelopment%22
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Remoundou, K. (author), Brennan, M. (author), Sacchettini, G. (author), Panzone, L. (author), Butler-Ellis, M.C. (author), Capri, E. (author), Charistou, A. (author), Chaideftou, E. (author), Gerritsen-Ebben, M.G. (author), Machera, K. (author), Spanoghe, P. (author), Glass, R. (author), Marchis, A. (author), Doanngoc, K. (author), Hart, A. (author), Frewer, L.J. (author)The EU Directive on the sustainable use of pesticides (EU128/2009/EC) requires European Member States to develop training activities targeting occupational exposure to pesticides, and communication material aimed at residents and bystanders. Risk perceptions, knowledge and attitudes associated with passive and occupational exposure to pesticide...article 2015
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Remoundou, K. (author), Brennana, M. (author), Sacchettini, G. (author), Panzone, L. (author), Butler-Ellis, M.C. (author), Capri, E. (author), Charistou, A. (author), Chaideftou, E. (author), Gerritsen-Ebben, M.G. (author), Machera, K. (author), Spanoghe, P. (author), Glass, R. (author), Marchis, A. (author), Doanngoc, K. (author), Hart, A. (author), Frewer, L.J. (author)The EU Directive on the sustainable use of pesticides (EU128/2009/EC) requires European Member States to develop training activities targeting occupational exposure to pesticides, and communication material aimed at residents and bystanders. Risk perceptions, knowledge and attitudes associated with passive and occupational exposure to pesticide...article 2015
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ter Burg, W. (author), Bokkers, B.G.H. (author), Kroese, E.D. (author), Schuur, A.G. (author)ABSTRACT: Health impact assessments (HIA) have become an important tool for applying evidence-based policy. Recently, the concept of HIA has been introduced in the field of chemical substances. Two main issues are encountered, i.e., the focus of risk assessment is deriving safe levels and on first signs of adverse effects. These adverse effects,...article 2015
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de Weerd, M. (author), Tierney, R. (author), van Duuren-Stuurman, B. (author), Bertranou, E. (author)This technical annex complements the report 'Estimating the cost of accidents and ill-health at work - a review of methodologies' by providing further details on each of the studies reviewed, including their results.book 2014
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Jonaid, B.S. (author), Pronk, A. (author), Doekes, G. (author), Heederik, D. (author)Background: Isocyanate asthma is one of the most frequently identified forms of occupational asthma in industrialised countries. The underlying mechanisms have not been clarified. There is only limited information about the relationship between exhaled nitric oxide (eNO) and occupational exposure to isocyanates and asthma. Objectives: To...article 2014
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Schinkel, J. (author), Fransman, W. (author), McDonnell, P.E. (author), Entink, R.K. (author), Tielemans, E. (author), Kromhout, H. (author)Objectives: The aim of this study was to assess the reliability of the Advanced REACH Tool (ART) by (i) studying interassessor agreement of the resulting exposure estimates generated by the ART mechanistic model, (ii) studying interassessor agreement per model parameters of the ART mechanistic model, (iii) investigating assessor characteristics...article 2014
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- de Groot, D.M.G. (author), Westerink, R.H.S. (author), Lammers, J.H.C.M. (author), Fox, D.A. (author), van Thriel, C. (author), Llorens, J. (author) article 2014
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Lucas Luijckx, N. (author), Blom, M. (author), Kruizinga, A. (author), Houben, G. (author)Dankzij verzamelde patiëntgegevens en kwantitatieve richtlijnen voor de belangrijke allergenen gaat het risicomanagement van allergenen veranderen, De producent kan risico's van kruiscontaminatie beter schatten in relatie tot de beheersing van allergenen in de productie, Door daarover duidelijk te communiceren, kan de consument deze risico's...article 2014
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- le Feber, M. (author) article 2014
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van Mierlo, G.J.D. (author), Cnubben, N.H.P. (author), Wouters, D. (author), Wolbink, G.J. (author), Hart, M.H.L. (author), Rispens, T. (author), Ganderup, N.C. (author), Kuper, C.F. (author), Aarden, L. (author), Penninks, A.H. (author)Immunogenicity is a major issue of concern for monoclonal antibodies used in human diseases and is by default mainly determined in non-human primates (NHP), as target molecules are considered most similar in NHP compared to human. In this manuscript the predictive value of immunogenicity testing in minipigs for human safety is evaluated, as the...article 2014
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Grinberg, M. (author), Stöber, R.M. (author), Edlund, K. (author), Rempel, E. (author), Godoy, P. (author), Reif, R. (author), Widera, A. (author), Madjar, K. (author), Schmidt-Heck, W. (author), Marchan, R. (author), Sachinidis, A. (author), Spitkovsky, D. (author), Hescheler, J. (author), Carmo, H. (author), Arbo, M.D. (author), van de Water, B. (author), Wink, S. (author), Vinken, M. (author), Rogiers, V. (author), Escher, S. (author), Hardy, B. (author), Mitic, D. (author), Myatt, G. (author), Waldmann, T. (author), Mardinoglu, A. (author), Damm, G. (author), Seehofer, D. (author), Nüssler, A. (author), Weiss, T.S. (author), Oberemm, A. (author), Lampen, A. (author), Schaap, M.M. (author), Luijten, M. (author), van Steeg, H. (author), Thasler, W.E. (author), Kleinjans, J.C.S. (author), Stierum, R.H. (author), Leist, M. (author), Rahnenführer, J. (author), Hengstler, J.G. (author)A long-term goal of numerous research projects is to identify biomarkers for in vitro systems predicting toxicity in vivo. Often, transcriptomics data are used to identify candidates for further evaluation. However, a systematic directory summarizing key features of chemically influenced genes in human hepatocytes is not yet available. To bridge...article 2014
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Garai, M. (author), Schoen, E. (author), Behler, G. (author), Bragado, B. (author), Chudalla, M. (author), Conter, M. (author), Defrance, J. (author), Demizieux, P. (author), Glorieux, C. (author), Guidorzi, P. (author)In Europe, in situ measurements of sound reflection and airborne sound insulation of noise barriers are usually done according to CEN/TS 1793-5. This method has been improved substantially during the EU funded QUIESST collaborative project. Within the same framework, an inter-laboratory test has been carried out to assess the repeatability and...article 2014
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Fostel, J. (author), van Someren, E. (author), Pronk, T. (author), Pennings, J. (author), Schmeits, P. (author), Shao, J. (author), Kroese, D. (author), Stierum, R. (author)Systems toxicology relies on data integration from a variety of disciplines. These include the toxicological phenotype and in vitro assay data, together with a system-wide response such as transcriptomics data. To facilitate this, databases to capture a variety of phenotypic data, along with so-called 'omics data and metadata describing the...bookPart 2014
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Leeman, W.R. (author), Krul, L. (author), Houben, G.F. (author)The threshold of toxicological concern (TTC) concept is a risk assessment tool for substances present at low oral exposure and lacking hazard data. In the past, several thresholds were elaborated by Munro et al. (1996) and Kroes et al. (2004). For these TTC thresholds, the Cramer class III threshold is based on a broad spectrum of substances,...article 2014
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van Deurssen, E. (author), Oude Hengel, K.M. (author), Spaan, S. (author), Goede, H. (author), Meijster, T. (author), Tielemans, E. (author), Heederik, D. (author), Pronk, A. (author)Objectives: A multidisciplinary intervention study aimed at reducing quartz exposure in the Dutch construction industry was performed. We aimed to assess the effect of the intervention on exposure level and psycho-social and organisational factors. Method: Eight participating construction companies were randomly allocated to an intervention (n =...article 2014
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Broekman, H. (author), Verhoeckx, K. (author), Gaspari, M. (author), den Hartog Jager, S. (author), Houben, G. (author), Knulst, A. (author)Patients with a shrimp allergy, can also react to similar allergens from other crustaceans, shellfish or mollusks. Due to the quest for new protein sources, insects are being looked at to see if they could be a source for these proteins. In vitro studies show that the crustacean allergic patients are at risk to develop allergic symptoms when...article 2014
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Oude Hengel, K.M. (author), van Deurssen, E. (author), Meijster, T. (author), Tielemans, E. (author), Heederik, D. (author), Pronk, A. (author)Background: Occupational quartz exposure continues to be a serious hazard in the construction industry. Until now, evidence-based interventions aimed at reducing quartz exposure are scarce. The aim of this study was to systematically develop an intervention and to describe the study to evaluate its effectiveness. Methods/design: The intervention...article 2014
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- Llorens, J. (author), van Thriel, C. (author), Fox, D.A. (author), Lammers, J. (author), Westerink, R.H.S. (author), de Groot, D.M.G. (author) article 2014
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Bodin, J. (author), Bølling, A.B. (author), Becher, R. (author), Kuper, F. (author), Løvik, M. (author), Nygaard, U.C. (author)Diabetes mellitus type 1 is an autoimmune disease with a genetic predisposition that is triggered by environmental factors during early life. Epidemiological studies show that bisphenol A (BPA), an endocrine disruptor, has been detected in about 90% of all analyzed human urine samples. In this study, BPA was found to increase the severity of...article 2014
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Losert, S. (author), von Goetz, N. (author), Bekker, C. (author), Fransman, W. (author), Wijnhoven, S.W.P. (author), Delmaar, C. (author), Hungerbuhler, K. (author), Ulrich, A. (author)The release of pesticides from conventional spray products has been investigated in depth, and suitable analytical techniques detecting the mass of the released substances are available. In contrast, nanoparticle-containing sprays are less studied, although they are perceived as critical for consumers because inhalation exposure can occur to...article 2014
Searched for: subject%3A%22RAPID%255C%2B%255C-%255C%2BRisk%255C%2BAssessment%255C%2BProducts%255C%2Bin%255C%2BDevelopment%22
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