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Dietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: Diet-gene interactions and promoter CpG island hypermethylation in colorectal cancer

de Vogel, S. (author), Wouters, K.A.D. (author), Gottschalk, R.W.H. (author), van Schooten, F.J. (author), de Goeij, A.F.P.M. (author), de Bruïne, A.P. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), van Engeland, M. (author), Weijenberg, M.P. (author)

Dietary methyl donors might influence DNA methylation during carcinogenesis of colorectal cancer (CRC). Among 609 CRC cases and 1,663 subcohort members of the Netherlands Cohort Study on diet and cancer (n = 120,852), we estimated CRC risk according to methyl donor intake across genotypes of folate metabolizing enzymes and methyltransferases....

article 2011

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Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer

de Vogel, S. (author), Dindore, V. (author), van Engeland, M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), Weijenberg, M.P. (author), TNO Kwaliteit van Leven (author)

Adequate intake of folate, methionine, riboflavin, and vitamin B-6 may prevent aberrant DNA methylation and thereby protect against colorectal cancer (CRC). However, previous epidemiological studies investigating associations between dietary intakes of these nutrients and CRC have been inconsistent. We investigated the associations between...

article 2008

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Walking or vitamin B for cognition in older adults with mild cognitive impairment? A randomised controlled trial

van Uffelen, J.G.Z. (author), Chinapaw, M.J.M. (author), van Mechelen, W. (author), Hopman-Rock, M. (author), TNO Kwaliteit van Leven (author)

Objective: To examine the effects of aerobic exercise or vitamin B supplementation on cognitive function in older adults with mild cognitive impairment (MCI). Design: Randomised placebo-controlled trial. Setting: General community. Participants: Community-dwelling adults aged 70-80 with MCI. Interventions : The 152 participants were randomly...

article 2008

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The effect of walking and vitamin B supplementation on quality of life in community-dwelling adults with mild cognitive impairment: A randomized, controlled trial

van Uffelen, J.G.Z. (author), Chin A Paw, M.J.M. (author), Hopman-Rock, M. (author), van Mechelen, W. (author), TNO Kwaliteit van Leven (author)

Objectives: To examine the effect of walking and vitamin B supplementation on quality-of-life (QoL) in community-dwelling adults with mild cognitive impairment. Methods: One year, double-blind, placebo-controlled trial. Participants were randomized to: (1) twice-weekly, group-based, moderate-intensity walking program (n = 77) or a light...

article 2007

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Effect of fortified spread on homocysteine concentration in apparently healthy volunteers

van Vliet, T. (author), Jacobs, R.G.J.M. (author), de Deckere, E. (author), van den Berg, H. (author), de Bree, A. (author), van der Put, N.M.J. (author), TNO Kwaliteit van Leven (author)

Objective: To determine the effect of folic acid, vitamin B6 and B12 fortified spreads on the blood concentrations of these vitamins and homocysteine. Design and setting: A 6-week randomized, double-blinded, placebo-controlled, parallel trial carried out in a clinical research center. Subjects: One hundred and fifty healthy volunteers (50% males...

article 2007

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Red blood cell folate vitamer distribution in healthy subjects is determined by the methylenetetrahydrofolate reductase C677T polymorphism and by the total folate status

Smulders, Y.M. (author), Smith, D.E.C. (author), Kok, R.M. (author), Teerlink, T. (author), Gellekink, H. (author), Vaes, W.H.J. (author), Stehouwer, C.D.A. (author), Jakobs, C. (author), TNO Kwaliteit van Leven (author)

Background: Red blood cells (RBCs) represent a storage pool for folate. In contrast to plasma, RBC folate can appear in different biochemical isoforms. So far, only the methylenetetrahydrofolate reductase (MTHFR) 677 TT genotype has been identified as a determinant of RBC folate vitamer distribution. Objective: The purpose of this study is to...

article 2007

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The EPIC nutrient database project (ENDB): A first attempt to standardize nutrient databases across the 10 European countries participating in the EPIC study

Slimani, N. (author), Deharveng, G. (author), Unwin, I. (author), Southgate, D.A.T. (author), Vignat, J. (author), Skeie, G. (author), Salvini, S. (author), Parpinel, M. (author), Møller, A. (author), Ireland, J. (author), Becker, W. (author), Farran, A. (author), Westenbrink, S. (author), Vasilopoulou, E. (author), Unwin, J. (author), Borgejordet, Å. (author), Rohrmann, S. (author), Church, S. (author), Gnagnarella, P. (author), Casagrande, C. (author), van Bakel, M. (author), Niravong, M. (author), Boutron-Ruault, M.C. (author), Stripp, C. (author), Tjønneland, A. (author), Trichopoulou, A. (author), Georga, K. (author), Nilsson, S. (author), Mattisson, I. (author), Ray, J. (author), Boeing, H. (author), Ocké, M. (author), Peeters, P.H.M. (author), Jakszyn, P. (author), Amiano, P. (author), Engeset, D. (author), Lund, E. (author), Santucci de Magistris, M. (author), Sacerdote, C. (author), Welch, A. (author), Bingham, S. (author), Subar, A.F. (author), Riboli, E. (author), TNO Kwaliteit van Leven (author)

Objective: This paper describes the ad hoc methodological concepts and procedures developed to improve the comparability of Nutrient databases (NDBs) across the 10 European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). This was required because there is currently no European reference NDB...

article 2007

document

Categorization of health risks from exposure to active pharmaceutical ingredients = Categorisatie van bereidingsrisico's

Tielemans, E. (author), Schaafsma, G. (author), de Heer, C. (author), Rijnders, E. (author), Groenewold, M. (author), Bouwman, Y. (author), TNO Kwaliteit van Leven (author)

article 2005

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Kinetics of homocysteine metabolism after moderate alcohol consumption

Beulens, J.W.J. (author), Sierksma, A. (author), Schaafsma, G. (author), Kok, F.J. (author), Struys, E.A. (author), Jakobs, C. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)

Background: Moderate alcohol consumption is associated with a decreased risk of cardiovascular disease. Because plasma homocysteine (tHcy) is considered an independent risk factor for cardiovascular disease and associated with alcohol consumption, the authors investigated the effect of moderate alcohol consumption on kinetics of plasma tHcy...

article 2005

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Choline supplemented as phosphatidylcholine decreases fasting and postmethionine-loading plasma homocysteine concentrations in healthy men

Olthof, M.R. (author), Brink, E.J. (author), Katan, M.B. (author), Verhoef, P. (author), TNO Kwaliteit van Leven (author)

Background: A high homocysteine concentration is a potential risk factor for cardiovascular disease that can be reduced through betaine supplementation. Choline is the precursor for betaine, but the effects of choline supplementation on plasma total homocysteine (tHcy) concentrations in healthy humans are unknown. Objective: The objective was to...

article 2005

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Protocol for Project FACT: A randomised controlled trial on the effect of a walking program and vitamin B supplementation on the rate of cognitive decline and psychosocial wellbeing in older adults with mild cognitive impairment

TNO Kwaliteit van Leven (author), van Uffelen, J.G.Z. (author), Hopman-Rock, M. (author), Chin A Paw, M.J.M. (author), van Mechelen, W. (author)

Background: the prevalence of individuals with cognitive decline is increasing since the number of elderly adults is growing considerably. The literature provides promising results on the beneficial effect of exercise and vitamin supplementation on cognitive function both in cognitively healthy as well as in the demented elderly. Methods/Design:...

article 2005

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Validation and sensitivity analysis of probabilistic models of dietary exposure to micronutrients: An example based on vitamin B6

TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author), Rubingh, C.M. (author), Kruizinga, A.G. (author), Hulshof, K.F.A.M. (author), Brussaard, J.H. (author)

Probabilistic modelling can be used to get an insight into the variability and uncertainty of the nutrient intake in a population. When a probabilistic model is used, it is important that it is validated. Furthermore, a sensitivity analysis of the model output can give an insight into the most important input variables of the model and can be...

article 2003

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Certification of B-group vitamins (b1, b2, b6, and b12) in four food reference materials

Ollilainen, V. (author), Finglas, P.M. (author), van den Berg, H. (author), de Froidmont-Görtz, I. (author)

In 1989, the Community Bureau of Reference started a research program to improve the quality of vitamin analysis in food. To achieve this task, vitamin methodology was evaluated and tested by interlaboratory studies and the preparation of certified reference materials, which will be used for quality control of vitamin measurements. The main...

article 2001

document

Vitamines en visvetzuren ter preventie van hart- en vaatziekten: Gezondmakers uit potjes en flesjes T2 = Health from jars and bottles. Vitamins and fish oil fatty acids for prevention of cardiovascular diseases

Severs, A.H. (author), Bouterse-van Haaren, M.R.T. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

A high dietary intake of antioxidants ascorbic acid, tocopherol and beta-carotene and 1 or 2 servings of fish per week is associated with a lower risk of coronary heart diseases, but the 'evidence' for a preventive effect still has not been produced. A raised homocysteine level can be lowered with folate, possibly in combination with pyridoxine...

article 2000

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Effect of consumption of red wine, spirits and beer on serum homocysteine

van der Gaag, M.S. (author), Ubbink, J.B. (author), Sillanaukee, P. (author), Nikkari, S. (author), Hendriks, H.F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

Serum homocysteine increases after moderate consumption of red wine and spirits, but not after moderate consumption of beer. Vitamin B6 in beer seems to prevent the alcohol-induced rise in serum homocysteine. Chemicals/CAS: Homocysteine, 454-28-4; Pyridoxine, 65-23-6

article 2000

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Approach of the US food and nutrition board to daily nutrient requirements: A useful basis for the European discussion on risk assessment of nutrients

Brussaard, J.H. (author), van den Berg, H. (author), Hermus, R.J.J. (author), Walter, P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

Objective: To discuss the approach of the US Food and Nutrition Board (FNB) to daily nutrient requirements and its relevance for Europe. Setting: A workshop for experts from academia and regulatory bodies, together with members from the FNB Dietary Reference Intakes Subcommittee on Upper Reference Levels of Intake, and from the B-vitamins Expert...

article 1999

document

Vitamin B6 status and requirements in older adults

Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author), van den Berg, H. (author)

Chemicals/CAS: Homocysteine, 454-28-4; Proteins; Pyridoxic Acid, 82-82-6; Pyridoxine, 65-23-6

article 1999

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Nutritional and psychological status of young women after a short-term use of a triphasic contraceptive steroid preparation

Massé, P.G. (author), van den Berg, H. (author), Livingstone, M.M. (author), Duguay, C. (author), Beaulieu, G. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)

The present study was aimed to assess the psychological status of young healthy women after the administration of a triphasic contraceptive steroid preparation for six complete menstrual cycles. Subjects had never used oral contraceptives (OC) and had neither a familial history of depression nor psychological disturbances. OC-induced...

article 1998

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Ageing and zonal variation in post-translational modification of collagen in normal human articular cartilage: The age-related increase in Non-Enzymatic Glycation affects biomechanical properties of cartilage

Bank, R.A. (author), Bayliss, M.T. (author), Lafeber, F.P.J.G. (author), Maroudas, A. (author), Tekoppele, J.M. (author), Gaubius Instituut TNO (author)

A biomechanical failure of the collagen network is postulated in many hypotheses of the development of osteoarthritis with advancing age. Here we investigate the accumulation of non-enzymatic glycation (NEG) products in healthy human articular cartilage, its relation to tissue remodelling and its role in tissue stiffening. Pentosidine levels...

article 1998

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Early effect of a low dose (30 μg) ethinyl estradiol-containing triphasil® on vitamin B6 status. A follow-up study on six menstrual cycles

Massé, P.G. (author), van den Berg, H. (author), Duguay, C. (author), Beaulieu, G. (author), Simard, J.M. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)

The objectives of the study were to follow-up six artificial menstrual cycles induced by Triphasil® in order to determine: 1) the time of apparition of B6 metabolic side-effects, in the eventuality they occur, and 2) the existence or non-existence of a normalization process and if so, when it is initiated. The choice of this triphasic OC...

article 1996