Searched for: subject%3A%22Protein%255C%2Bcross%255C%2Blinking%22
(1 - 10 of 10)
document
Balguid, A. (author), Rubbens, M.P. (author), Mol, A. (author), Bank, R.A. (author), Bogers, A.J.J.C. (author), van Kats, J.P. (author), de Mol, B.A.J.M. (author), Baaijens, F.P.T. (author), Bouten, C.V.C. (author), TNO Kwaliteit van Leven (author)
A major challenge in tissue engineering of functional heart valves is to determine and mimic the dominant tissue structures that regulate heart valve function and in vivo survival. In native heart valves, the anisotropic matrix architecture assures sustained and adequate functioning under high-pressure conditions. Collagen, being the main load...
article 2007
document
Jenniskens, Y.M. (author), Koevoet, W. (author), de Bart, A.C.W. (author), Weinans, H. (author), Jahr, H. (author), Verhaar, J.A.N. (author), de Groot, J. (author), van Osch, G.J.V.M. (author), TNO Kwaliteit van Leven (author)
Objective: Examine effects of insulin-like growth factor 1 (IGF1), transforming growth factor β2 (TGFβ2) and fibroblast growth factor 2 (FGF2) on proteoglycan and collagen network and biomechanical properties of the newly formed cartilage matrix. Methods: Bovine articular chondrocytes were cultured in alginate beads for 3 weeks with or without...
article 2006
document
Pfeiffer, B.J. (author), Franklin, C.L. (author), Hsieh, F.H. (author), Bank, R.A. (author), Phillips, C.L. (author), TNO Preventie en Gezondheid (author)
Collagen and elastin are the primary determinants of vascular integrity, with elastin hypothesized to be the major contributor to aortic compliance and type I collagen the major contributor to aortic strength and stiffness. Type I collagen is normally heterotrimeric composed of two α1(I) and one α2(I) collagen chains, α1(I)2α2(I). Recent...
article 2005
document
Zuurmond, A.M. (author), Slot van der-Verhoeven, A.J. (author), van Dura, E.A. (author), de Groot, J. (author), Bank, R.A. (author), TNO Kwaliteit van Leven (author)
Collagen deposits in fibrotic lesions often display elevated levels of hydroxyallysine (pyridinoline) cross-links. The relation between the occurrence of pyridinoline cross-links and the irreversibility of fibrosis suggests that these cross-links contribute to the aberrant accumulation of collagen. Based on its inhibitory effect on lysyl...
article 2005
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Boeriu, C.G. (author), Oudgenoeg, G. (author), Spekking, W.T.J. (author), Berendsen, L.B.J.M. (author), Vancon, L. (author), Boumans, H. (author), Gruppen, H. (author), van Berkel, W.J.H. (author), Laane, C. (author), Voragen, A.G.J. (author), TNO Voeding (author)
Heterologous conjugates of wheat arabinoxylan and β-casein were prepared via enzymatic cross-linking, using sequential addition of the arabinoxylan to a mixture of β-casein, peroxidase, and hydrogen peroxide. The maximal formation of adducts between the β-casein and the feruloylated arabinoxylan was reached at a protein-to-arabinoxylan ratio of...
article 2004
document
Verzijl, N. (author), de Groot, J. (author), Zaken, C.B. (author), Braun-Benjamin, O. (author), Maroudas, A. (author), Bank, R.A. (author), Mizrahi, J. (author), Schalkwijk, C.G. (author), Thorpe, S.R. (author), Baynes, J.W. (author), Bijlsma, J.W.J. (author), Lafeber, F.P.J.G. (author), TeKoppele, J.M. (author), Gaubius Instituut TNO (author)
Objective. Age is an important risk factor for osteoarthritis (OA). During aging, nonenzymatic glycation results in the accumulation of advanced glycation end products (AGEs) in cartilage collagen. We studied the effect of AGE crosslinking on the stiffness of the collagen network in human articular cartilage. Methods. To increase AGE levels,...
article 2002
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Wassen, M.H.M. (author), Lammens, J. (author), Tekoppele, J.M. (author), Sakkers, R.J.B. (author), Liu, Z. (author), Verbout, A.J. (author), Bank, R.A. (author)
Although >80% of the mineral in mammalian bone is present in the collagen fibrils, limited information is available about factors that determine a proper deposition of mineral. This study investigates whether a specific collagen matrix is required for fibril mineralization. Calcifying callus from dog tibias was obtained at various times (3-21...
article 2000
document
Verzijl, N. (author), de Groot, J. (author), Oldehinkel, E. (author), Bank, R.A. (author), Thorpe, S.R. (author), Baynes, J.W. (author), Bayliss, M.T. (author), Bijlsma, J.W.J. (author), Lafeber, F.P.J.G. (author), TeKoppele, J.M. (author), Gaubius Laboratory, Div. Vasc./Connective Tissue Res., TNO Prevention and Health, PO Box 2215, 2301 CE Leiden, Netherlands (author)
Non-enzymic modification of tissue proteins by reducing sugars, the so-called Maillard reaction, is a prominent feature of aging. In articular cartilage, relatively high levels of the advanced glycation end product (AGE) pentosidine accumulate with age. Higher pentosidine levels have been associated with a stiffer collagen network in cartilage....
article 2000
document
Beekman, B. (author), Verzijl, N. (author), Bank, R.A. (author), Von Der Mark, K. (author), TeKoppele, J.M. (author), TNO Preventie en Gezondheid (author)
The extracellular matrix synthesized by articular chondrocytes cultured in alginate beads was investigated. Collagen levels increased sigmoidally with time and remained constant after 2 weeks of culture. The presence of cartilage-specific type II collagen was confirmed immunohistochemically. Predominantly type H collagen was present in the...
article 1997
document
te Koppele, J.M. (author), 't Hart, B.A. (author), Gaubius Instituut TNO (author)
article 1995
Searched for: subject%3A%22Protein%255C%2Bcross%255C%2Blinking%22
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