Searched for: subject:"Protein%5C%2BBinding"
(1 - 20 of 26)

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Damsten, M.C. (author), Commandeur, J.N.M. (author), Fidder, A. (author), Hulst, A.G. (author), Touw, D. (author), Noort, D. (author), Vermeulen, N.P.E. (author), TNO Defensie en Veiligheid (author)
Covalent binding of reactive electrophilic intermediates to proteins is considered to play an important role in the processes leading to adverse drug reactions and idiosyncratic drug reactions. Consequently, both for the discovery and the development of new drugs, there is a great interest in sensitive methodologies that enable the detection of...
article 2007
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Westerterp, M. (author), Berbée, J.F.P. (author), Delsing, D.J.M. (author), Jong, M.C. (author), Gijbels, M.J.J. (author), Dahlmans, V.E.H. (author), Offerman, E.H. (author), Romijn, J.A. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), TNO Kwaliteit van Leven (author)
Mice that overexpress human apolipoprotein C-I (apoC-I) homozygously (APOC1+/+ mice) are protected against obesity and show cutaneous abnormalities. Although these effects can result from our previous observation that apoC-I inhibits FFA generation by LPL, we have also found that apoC-I impairs the uptake of a FFA analog in adipose tissue. In...
article 2007
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Basketter, D. (author), Pease, C. (author), Kasting, G. (author), Kimber, I. (author), Casati, S. (author), Cronin, M. (author), Diembeck, W. (author), Gerberick, F. (author), Hadgraft, J. (author), Hartung, T. (author), Marty, J.P. (author), Nikolaidis, E. (author), Patlewicz, G. (author), Roberts, D. (author), Roggen, E. (author), Rovida, C. (author), van de Sandt, J. (author), TNO Kwaliteit van Leven (author)
article 2007
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Pant, N. (author), Hultberg, A. (author), Zhao, Y. (author), Svensson, L. (author), Pan-Hammarström, Q. (author), Johansen, K. (author), Pouwels, P.H. (author), Ruggeri, F.M. (author), Hermans, P. (author), Frenken, L. (author), Borén, T. (author), Marcotte, H. (author), Hammarström, L. (author), TNO Preventie en Gezondheid (author)
Background. Rotavirus-induced diarrhea poses a worldwide medical problem in causing substantial morbidity and mortality among children in developing countries. We therefore developed a system for passive immunotherapy in which recombinant lactobacilli constitutively express neutralizing variable domain of llama heavy-chain (VHH) antibody...
article 2006
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Valstar, D.L. (author), Schijf, M.A. (author), Arts, J.H.E. (author), Kuper, C.F. (author), Nijkamp, F.P. (author), Storm, G. (author), Bloksma, N. (author), Henricks, P.A.J. (author), TNO Kwaliteit van Leven (author)
Occupational exposure to low molecular weight chemicals, like trimellitic anhydride (TMA), can result in occupational asthma. Alveolar macrophages (AMs) are among the first cells to encounter these inhaled compounds and were previously shown to affect TMA-induced asthma-like symptoms in the Brown Norway rat (Valstar et al., Toxicol. Appl....
article 2006
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de Jong, R.J. (author), Verwei, M. (author), West, C.E. (author), van Vliet, T. (author), Siebelink, E. (author), van den Berg, H. (author), Castenmiller, J.J.M. (author), TNO Kwaliteit van Leven (author)
Objective: The aim of this study was to investigate whether milk fortified with folic acid enhances the folate status of humans and whether the presence of folate-binding proteins (FBP) in pasteurised milk affects the bioavailability of folic acid from fortified milk. In untreated and pasteurised milk, folate occurs bound to FBP, while FBP is ...
article 2005
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Berbée, J.F.P. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), TNO Kwaliteit van Leven (author)
An increasing body of evidence demonstrates a close interplay between lipoprotein metabolism and sepsis. Sepsis results in an increase of plasma triglycerides within VLDL as a consequence of an enhanced hepatic VLDL production and/or inhibited peripheral and hepatic VLDL clearance. In contrast, sepsis decreases plasma cholesterol within LDL and...
article 2005
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Joosten, V. (author), Roelofs, M.S. (author), van den Dries, N. (author), Goosen, T. (author), Verrips, C.T. (author), van den Hondel, C.A.M.J.J. (author), Lokman, B.C. (author), TNO Kwaliteit van Leven (author)
The Arthromyces ramosus peroxidase gene (arp) was genetically fused to either the 5′- or 3′-terminal ends of the gene encoding llama variable heavy chain antibody fragment VHH R9, resulting in the fusion expression cassettes ARP-R9 or R9-ARP. Aspergillus awamori transformants were obtained which produced up to 30 mg l-1 fusion protein in the...
article 2005
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Wortelboer, H.M. (author), Usta, M. (author), van Zanden, J.J. (author), van Bladeren, P.J. (author), Rietjens, I.M.C.M. (author), Cnubben, N.H.P. (author), TNO Kwaliteit van Leven (author)
To study the possible interplay between glutathione metabolism of and MRP inhibition by thiol reactive compounds, the interactions of a series of α,β-unsaturated carbonyl compounds with multidrug resistance proteins 1 and 2 (MRP1/ABCC1 and MRP2/ABCC2) were studied. α,β-Unsaturated carbonyl compounds react with glutathione, and therefore either...
article 2005
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Coecke, S. (author), Blaauboer, B.J. (author), Elaut, G. (author), Freeman, S. (author), Freidig, A. (author), Gensmantel, N. (author), Hoet, P. (author), Kapoulas, V.M. (author), Ladstetter, B. (author), Langley, G. (author), Leahy, D. (author), Mannens, G. (author), Meneguz, A. (author), Monshouwer, M. (author), Nemery, B. (author), Pelkonen, O. (author), Pfaller, W. (author), Prieto, P. (author), Proctor, N. (author), Rogiers, V. (author), Rostami-Hodjegan, A. (author), Sabbioni, E. (author), Steiling, W. (author), van de Sandt, J.J.M. (author), TNO Kwaliteit van Leven (author)
article 2005
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Verwei, M. (author), Arkbåge, K. (author), Mocking, H. (author), Havenaar, R. (author), Groten, J. (author), TNO Voeding (author)
Despite its low natural folate concentration, milk is responsible for 10-15% of the daily folate intake in countries with a high dairy consumption. Milk products can be considered as a potential matrix for folate fortification, e.g., with synthetic folic acid, to enhance the daily intake of folate. In untreated milk, the natural folate, 5...
article 2004
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Smulders, C.J.G.M. (author), Bueters, T.J.H. (author), Vailati, S. (author), van Kleef, R.G.D.M. (author), Vijvergberg, H.P.M. (author)
Chronic and acute exposure to organophosphate (OP) pesticides may lead to persistent neurological and neurobehavioral effects, which cannot be explained by acetylcholinesterase (AChE) inhibition alone. It is suggested that other brain proteins are involved. Effects of commonly used organophosphate pesticides on rat neuronal α4β2 nicotinic...
article 2004
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Nieuwenhuizen, W.F. (author), Dekker, H.L. (author), Gröneveld, T. (author), de Koster, C.G. (author), de Jong, G.A.H. (author), TNO Voeding (author)
Bovine β-lactoglobulin (BLG) is a major component in whey and its physical properties are important for the texture of many dairy-based foods. Modification of proteins with transglutaminase from Streptoverticillium mobaraense (MTGase) can be used to alter their physical properties. MTGase-mediated modification of native BLG was until now,...
article 2004
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Kosters, H.A. (author), Broersen, K. (author), de Groot, J. (author), Simons, J.W.F.A. (author), Wierenga, P. (author), de Jongh, H.H.J. (author), TNO Voeding (author)
Processing of ovalbumin may result in proteins that differ more than 23°C in denaturation temperature while the structural fold is not significantly affected. This is achieved by 1) conversion of positive residues into negative ones (succinylation); 2) elimination of negative charges (methylation); 3) reducing the proteins hydrophobic exposure ...
article 2003
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Nguyen, M.T. (author), Beck, J. (author), Lue, H. (author), Fünfzig, H. (author), Kleemann, R. (author), Koolwijk, P. (author), Kapurniotu, A. (author), Bernhagen, J. (author), Gaubius Instituut TNO (author)
Macrophage migration inhibitory factor (MIF) is a cytokine that participates in the host inflammatory response. A Cys-Xaa-Xaa-Cys (CXXC)-based thiol-protein oxidoreductase activity of MIF is associated with certain biological functions. Peptides spanning the CXXC region of thiol-protein oxidoreductases retain some biochemical properties of the...
article 2003
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Kleemann, R. (author), Gervois, P.P. (author), Verschuren, L. (author), Staels, B. (author), Princen, H.M.G. (author), Kooistra, T. (author), Gaubius Instituut TNO (author)
C-reactive protein (CRP) is a major acute-phase protein in humans. Elevated plasma CRP levels are a risk factor for cardiovascular disease. CRP is predominantly expressed in hepatocytes and is induced by interleukin-1 (IL-1) and IL-6 under inflammatory situations, such as the acute phase. Fibrates are hypolipidemic drugs that act through the...
article 2003
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Arkbåge, K. (author), Verwei, M. (author), Havenaar, R. (author), Witthöft, C. (author), TNO Voeding (author)
Milk products are only moderate sources of folate. Nevertheless, they are of interest due to their content of folate-binding proteins (FBP), which in some studies have been reported to increase folate bioavailability. The effect of FBP on folate bioavailability has been widely discussed. The aim of this study was to investigate the...
article 2003
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O'Connor, D.H. (author), Mothe, B.R. (author), Weinfurter, J.T. (author), Fuenger, S. (author), Rehrauer, W.M. (author), Jing, P. (author), Rudersdorf, R.R. (author), Liebl, M.E. (author), Krebs, K. (author), Vasquez, J. (author), Dodds, E. (author), Loffredo, J. (author), Martin, S. (author), McDermott, A.B. (author), Allen, T.M. (author), Wang, C. (author), Doxiadis, G.G. (author), Montefiori, D.C. (author), Hughes, A. (author), Burton, D.R. (author), Allison, D.B. (author), Wolinsky, S.M. (author), Bontrop, R. (author), Picker, L.J. (author), Watkins, D.I. (author)
Certain major histocompatibility complex class I (MHC-I) alleles are associated with delayed disease progression in individuals infected with human immunodeficiency virus (HIV) and in macaques infected with simian immunodeficiency virus (SIV). However, little is known about the influence of these MHC alleles on acute-phase cellular immune...
article 2003
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van der Schans, G.P. (author), Noort, D. (author), Mars-Groenendijk, R.H. (author), Fidder, A. (author), Chau, L.F. (author), de Jong, L.P.A. (author), Benschop, H.P. (author), Prins Maurits Laboratorium TNO (author)
As part of a program to develop methods for diagnosis of exposure to chemical warfare agents, we developed immunochemical methods for detection of adducts of sulfur mustard to keratin in human skin. Three partial sequences of keratins containing glutamine or asparagine adducted with a 2-hydroxyethylthioethyl group at the ω-amide function were...
article 2002
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Noort, D. (author), Benschop, H.P. (author), Black, R.M. (author), Prins Maurits Laboratorium TNO (author)
In this report an overview of the methods currently available for detection of exposure to a number of chemical warfare agents (CWA), i.e., sulfur mustard, lewisite and nerve agents, is presented. Such methods can be applied for various purposes, e.g., diagnosis and dosimetry of exposure of casualties, confirmation of nonexposure, verification...
article 2002
Searched for: subject:"Protein%5C%2BBinding"
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