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Bogerd, C.P. (author), Langenberg, J.P. (author), den Hartog, E.A. (author)Armed forces typically have personal protective clothing (PPC) in place to offer protection against chemical, biological, radiological and nuclear (CBRN) agents. The regular soldier is equipped with permeable CBRN-PPC. However, depending on the operational task, these PPCs pose too much thermal strain to the wearer, which results in a higher...article 2018
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Horn, G. (author), de Koning, M.C. (author), van Grol, M. (author), Thiermann, H. (author), Worek, F. (author)Poisoning by organophosphorus compounds (OP) is characterized by inhibition of the key enzyme acetylcholinesterase (AChE) and potentially fatal outcomes in humans. Insufficient efficacy of the standard therapy with atropine and AChE reactivators (oximes) against certain OP initiated synthesis of novel non-oxime reactivators basing on the common...article 2018
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von Benda-Beckmann, A.M. (author), Thomas, L. (author), Tyack, P.L. (author), Ainslie, M.A. (author)Passive acoustic monitoring with widely-dispersed hydrophones has been suggested as a cost-effective method to monitor population densities of echolocating marine mammals. This requires an estimate of the area around each receiver over which vocalizations are detected - the "effective detection area" (EDA). In the absence of auxiliary...article 2018
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Podborski, D. (author), Thomas, E. (author), Hannuksela, M.M. (author), Oh, S. (author), Stockhammer, T. (author), Pham, S. (author)Virtual reality (VR) has gained a lot of attention due to market availability of consumer devices. A challenge for wider use is the ability to stream VR content to the user. This paper looks at aspects of 360° video streaming and the considerations for possible solutions. The primary focus lies on current efforts to develop standards for...article 2018
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Bischoff, L.J.M. (author), Wolters, L. (author), ter Braak, B. (author), Langenberg, J.P. (author), Noort, D. (author), Beltman, J.B. (author), van de Water, B. (author), TNO Defensie en Veiligheid (author)Oxidative stress leads to the activation of the Nuclear factor-erythroid-2-related factor 2 (Nrf2) pathway. While most studies have focused on the activation of the Nrf2 pathway after single chemical treatment, little is known about the dynamic regulation of the Nrf2 pathway in the context of repeated exposure scenarios. Here we employed single...article 2018
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- Veeningen, M. (author), Chatterjea, S. (author), Horváth, A.Z. (author), Spindler, G. (author), Boersma, E. (author), van der Spek, P. (author), van der GaliËn, O. (author), Gutteling, J. (author), Kraaij, W. (author), Veugen, P.J.M. (author) conference paper 2018
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van Lieshout, M.J. (author), Emmert, S.B. (author)The right to privacy is enshrined in the European charter of fundamental rights. The right to data protection is a relatively novel right, also enshrined in the same European charter. While these rights seem to focus on a defensive and protective approach, they also give rise to a positive and constructive interpretation. The GDPR may act as...conference paper 2018
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van der Heijden, A.E.D.M. (author)In the domain of energetic nanomaterials, more specifically nano-sized explosives and oxidizers, many small scale production methods have been explored up to now. So far only limited attempts have been made to scale up the production to tens or maximally a few hunderds of grams. This paper provides a review of these small scale production...article 2018
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Ullwer, C. (author), Sprung, D. (author), van Eijk, A.M.J. (author), Gunter, W. (author), Stein, K. (author)Atmospheric turbulence impacts on the propagation of electro-optical radiation. Typical manifestations of optical turbulence are scintillation (intensity fluctuations), beam wander and (for laser systems) reduction of beam quality. For longer propagation channels, it is important to characterize the vertical and horizontal distribution ...conference paper 2018
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Meerhoff, G.F. (author), Vester, S.M. (author), Hesseling, P. (author), Klaassen, S.D. (author), Cornelissen, A.S. (author), Lucassen, P.J. (author), Joosen, J.A. (author)Organophosphate (OP) induced seizures are commonly treated with anticholinergics, oximes and anticonvulsants. Inhibition of P-glycoprotein (PgP) has been shown to enhance the efficacy of nerve agent treatment in soman exposed rats. In the present study, the promising effects of the PgP inhibitor tariquidar were investigated in more detail in...article 2018
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da Silva, J.A.V. (author), Modesto-Costa, L. (author), de Koning, M.C. (author), Borges, I.Jr. (author), França, T.C.C. (author)In this work, quaternary and non-quaternary oximes designed to bind at the peripheral site of acetylcholinesterase previously inhibited by organophosphates were investigated theoretically. Some of those oximes have a large number of degrees of freedom, thus requiring an accurate method to obtain molecular geometries. For this reason, the density...article 2018
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de Koning, M.C. (author), Horn, G. (author), van Grol, M. (author)Organophosphorous (OP) compounds (such as nerve agents) inhibit the enzyme acetylcholinesterase (AChE) by covalent phosphylation of a key serine residue in the active site of the enzyme resulting in severe symptoms and ultimately death. OP intoxications are currently treated by administration of certain oxime compounds. The presently fielded...conference paper 2018
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Dijkers, H.P.A. (author), Hooijmeijer, P.A. (author)Ammunition transshipments are a key part of the logistical operations of the armed forces and are often executed via ships. These transshipments pose a risk to the people present in the area surrounding the harbor, where the loading/unloading of the ship takes place. A method is presented to perform a quantitative risk assessment of such...conference paper 2018
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Verolme, E.K. (author), van der Voort, M.M. (author), Smits, R. (author), Weerheijm, J. (author), Koh, Y.H. (author), Kang, K.W. (author)There is limited knowledge on deriving the strength of an explosion based on the observed explosion effects. Existing methods are based primarily on the effects of blast overpressure on surrounding structures. Window breakage and structural damage are well studied and are widely used to derive most probable explosion strengths. Other explosive...article 2018
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Nooren, P.A. (author), van Gorp, N. (author), van Eijk, N. (author), Fathaigh, R.O. (author)The economic and societal impact of digital platforms raises a number of questions for policymakers, including whether existing regulatory approaches and instruments are sufficient to promote and safeguard public interests. This article develops a practical framework that provides structure and guidance to policymakers who design policies for...article 2018
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- Mohammed, S. (author), Schoolderman, A.J. (author) conference paper 2018
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Efficacy of atropine sulfate/obidoxime chloride co-formulation against sarin exposure in guinea pigsJoosen, M.J.A. (author), Klaassen, S.D. (author), Verheij, E. (author), van Groningen, T. (author), Cornelissen, A.S. (author), Skiadopoulos, M.H. (author), Cochrane, L. (author), Shearer, J.D. (author)The efficacy and pharmacokinetics of the aqueous co-formulation contents of the Trobigard™ (atropine sulfate, obidoxime chloride) auto-injector were evaluated in a sarin exposed guinea pig model. Two subcutaneous (sc) sarin challenge doses were evaluated in guinea pigs instrumented with brain and heart electrodes for electroencephalogram (EEG)...article 2018
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Goede, H. (author), de Vries, Y.C. (author), Kuijpers, E. (author), Fransman, W. (author)This review describes an evaluation of the effectiveness of Risk Management Measures (RMM) for nanomaterials in the workplace. Our aim was to review the effectiveness of workplace RMM for nanomaterials and to determine whether established effectiveness values of conventional chemical substances applied for modelling purposes should be adopted or...article 2018
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- book 2018
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- report 2018