Improved adjusted minimal important change took reliability of transition ratings into account

Objectives: The anchor-based minimal important change (MIC), based on the receiver operating characteristic (ROC) analysis or predictive modeling, is biased by the proportion of improved patients. The adjusted MIC, published in 2017, adjusts the predictive MIC for this bias but does not take the reliability of the transition ratings (i.e., the...

The anchor-based minimal important change, based on receiver operating characteristic analysis or predictive modeling, may need to be adjusted for the proportion of improved patients

Objectives. Patients have their individual minimal important changes (iMICs) as their personal benchmarks to determine whether a perceived health-related quality of life (HRQOL) change constitutes a (minimally) important change for them. We denote the mean iMIC in a group of patients as the “genuine MIC” (gMIC). The aims of this paper are to...