Searched for: subject%3A%22Procollagen%255C-Lysine%252C%255C%2B2%255C-Oxoglutarate%255C%2B5%255C-Dioxygenase%22
(1 - 8 of 8)
document
Jenniskens, Y.M. (author), Koevoet, W. (author), de Bart, A.C.W. (author), Weinans, H. (author), Jahr, H. (author), Verhaar, J.A.N. (author), de Groot, J. (author), van Osch, G.J.V.M. (author), TNO Kwaliteit van Leven (author)
Objective: Examine effects of insulin-like growth factor 1 (IGF1), transforming growth factor β2 (TGFβ2) and fibroblast growth factor 2 (FGF2) on proteoglycan and collagen network and biomechanical properties of the newly formed cartilage matrix. Methods: Bovine articular chondrocytes were cultured in alginate beads for 3 weeks with or without...
article 2006
document
Brinckmann, J. (author), Kim, S. (author), Wu, J. (author), Reinhardt, D.P. (author), Batmunkh, C. (author), Metzen, E. (author), Notbohm, H. (author), Bank, R.A. (author), Krieg, T. (author), Hunzelmann, N. (author), TNO Kwaliteit van Leven (author)
The major pathological processes of systemic scleroderma (SSc) comprise inflammation and microvascular damage in the early or acute progressive stage as well as tissue fibrosis and hypoxia in the chronic end stage. Fibrosis seems to be a general phenomenon characterized by an increase of hydroxylysine aldehyde derived collagen cross-links which...
article 2005
document
Zuurmond, A.M. (author), Slot van der-Verhoeven, A.J. (author), van Dura, E.A. (author), de Groot, J. (author), Bank, R.A. (author), TNO Kwaliteit van Leven (author)
Collagen deposits in fibrotic lesions often display elevated levels of hydroxyallysine (pyridinoline) cross-links. The relation between the occurrence of pyridinoline cross-links and the irreversibility of fibrosis suggests that these cross-links contribute to the aberrant accumulation of collagen. Based on its inhibitory effect on lysyl...
article 2005
document
van der Slot, A.J. (author), van Dura, E.A. (author), de Wit, E.C. (author), de Groot, J. (author), Huizinga, T.W.J. (author), Bank, R.A. (author), Zuurmond, A.M. (author), TNO Preventie en Gezondheid (author)
The hallmark of fibrosis is the excessive accumulation of collagen. The deposited collagen contains increased pyridinoline cross-link levels due to an overhydroxylation of lysine residues within the collagen telopeptides. Lysyl hydroxylase 2b (LH2b) is the only lysyl hydroxylase consistently up-regulated in several forms of fibrosis, suggesting...
article 2005
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Walker, L.C. (author), Overstreet, M.A. (author), Siddiqui, A. (author), de Paepe, A. (author), Ceylaner, G. (author), Malfait, F. (author), Symoens, S. (author), Atsawasuwan, P. (author), Yamauchi, M. (author), Ceylaner, S. (author), Bank, R.A. (author), Yeowell, H.N. (author), TNO Preventie en Gezondheid (author)
The clinical diagnosis of a patient with the phenotype of Ehlers-Danlos syndrome type VI was confirmed biochemically by the severely diminished level of lysyl hydroxylase (LH) activity in the patient's skin fibroblasts. A novel homozygous mutation, a single base change of T1360 → G in exon 13 of the LH1 gene, predicted to result in W446G, was...
article 2005
document
TNO Preventie en Gezondheid (author), Ha-Vinh, R. (author), Alanay, Y. (author), Bank, R.A. (author), Campos-Xavier, A.B. (author), Zankl, A. (author), Superti-Furga, A. (author), Bonafé, L. (author)
Bruck syndrome (BS) is a recessively-inherited phenotypic disorder featuring the unusual combination of skeletal changes resembling osteogenesis imperfects (OI) with congenital contractures of the large joints. Clinical heterogeneity is apparent in cases reported thus far. While the genes coding for collagen 1 chains are unaffected in BS, there...
article 2004
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TNO Preventie en Gezondheid (author), van der Slot, A.J. (author), Zuurmond, A.M. (author), Bardoel, A.F.J. (author), Wijmenga, C. (author), Pruijs, H.E.H. (author), Sillence, D.O. (author), Brinckmann, J. (author), Abraham, D.J. (author), Black, C.M. (author), Verzijl, N. (author), de Groot, J. (author), Hanemaaijer, R. (author), te Koppele, J.M. (author), Huizinga, T.W.J. (author), Bank, R.A. (author)
The hallmark of fibrotic processes is an excessive accumulation of collagen. The deposited collagen shows an increase in pyridinoline cross-links, which are derived from hydroxylated lysine residues within the telopeptides. This change in cross-linking is related to irreversible accumulation of collagen in fibrotic tissues. The increase in...
article 2003
document
Bank, R.A. (author), Robins, S.P. (author), Wijmenga, C. (author), Breslau-Siderius, L.J. (author), Bardoel, A.F.J. (author), van der Sluijs, H.A. (author), Pruijs, H.E.H. (author), Tekoppele, J.M. (author)
Bruck syndrome is characterized by the presence of osteoporosis, joint contractures, fragile bones, and short stature. We report that lysine residues within the telopeptides of collagen type I in bone are underhydroxylated, leading to aberrant crosslinking, but that the lysine residues in the triple helix are normally modified. In contrast to...
article 1999
Searched for: subject%3A%22Procollagen%255C-Lysine%252C%255C%2B2%255C-Oxoglutarate%255C%2B5%255C-Dioxygenase%22
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