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van Avesaat, M. (author), Troost, F.J. (author), Ripken, D. (author), Hendriks, H.F. (author), Aam, M. (author)BACKGROUND: Activation of the ileal brake, by infusing lipid directly into the distal part of the small intestine, alters gastrointestinal (GI) motility and inhibits food intake. The ileal brake effect on eating behavior of the other macronutrients is currently unknown. OBJECTIVE: The objective of this study was to investigate the effects of...article 2015
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Schrieks, I.C. (author), Stafleu, A. (author), Griffioen-Roose, S. (author), de Graaf, C. (author), Witkamp, R.F. (author), Boerrigter-Rijneveld, R. (author), Hendriks, H.F.J. (author)The aim of this study was to investigate whether food reward plays a role in the stimulating effect of moderate alcohol consumption on subsequent food intake. In addition, we explored the role of oral and gut sensory pathways in alcohol's effect on food reward by modified sham feeding (MSF) or consumption of a preload after alcohol intake.In a...article 2015
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van Avesaat, M. (author), Troost, F.J. (author), Ripken, D. (author), Peters, J. (author), Hendriks, H.F.J. (author), Masclee, A.A.M. (author)Background: Taste receptors are expressed not only in taste buds but also in the gastrointestinal tract. It has been hypothesized that these receptors may play a role in satiety and food intake. Objective: This study investigated the effect of intraduodenal tastant infusions (bitter, sweet, and umami) on food intake, hunger and fullness,...article 2015
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Tsikas, D. (author), Pham, V.V. (author), Suchy, M.T. (author), van de Ree, M.A. (author), Huisman, M.V. (author), Frölich, J.C. (author), Princen, H.M.G. (author)The present study describes the effects of atorvastatin on whole body synthesis of nitric oxide (NO), prostacyclin (PGI2), and thromboxane A2 (TxA2), on oxidative stress and nitrite/nitrate-related renal carbonic anhydrase (CA) activity in patients with type 2 diabetes mellitus (T2DM). A double-blind, randomized, placebo-controlled parallel...article 2015
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Kroese, E.D. (author), Bosgra, S. (author), Buist, H.E. (author), Lewin, G. (author), van der Linden, S.C. (author), Man, H.Y. (author), Piersma, A.H. (author), Rorije, E. (author), Schulpen, S.H.W. (author), Schwarz, M. (author), Uibel, F. (author), van Vugt-Lussenburg, B.M.A. (author), Wolterbeek, A.P.M. (author), van der Burg, B. (author)Previously we showed a battery consisting of CALUX transcriptional activation assays, the ReProGlo assay, and the embryonic stem cell test, and zebrafish embryotoxicity assay as 'apical' tests to correctly predict developmental toxicity for 11 out of 12 compounds, and to explain the one false negative [7]. Here we report on applying this battery...article 2015
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Stalman, S.E. (author), Hellinga, I. (author), van Dommelen, P. (author), Hennekam, R.C.M. (author), Saari, A. (author), Sankilampi, U. (author), Dunkel, L. (author), Wit, J.M. (author), Kamp, G.A. (author), Plötz, F.B. (author)Aims: To evaluate three guidelines for selecting short children for diagnostic workup in a general pediatric clinic. Methods: All patients (n = 131) aged 3.00-9.99 years who were referred for growth failure to a general pediatric clinic were evaluated for their medical history and growth and examined. All of them underwent the same standardized...article 2015
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Buist, H.E. (author), Devito, S. (author), Goldbohm, R.A. (author), Stierum, R.H. (author), Venhorst, J. (author), Kroese, E.D. (author)Carbon capture and storage (CCS) technologies are considered vital and economic elements for achieving global CO2 reduction targets, and is currently introduced worldwide (for more information on CCS, consult for example the websites of the International Energy Agency (http://www.iea.org/topics/ccs/) and the Global CCS Institute (http://www...article 2015
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Kempker, P.L. (author), Ran, A.C.M. (author), van Schuppen, J.H. (author)Coordinated linear systems are a particular class of hierarchical systems with a top-to-bottom information structure, consisting of a coordinator system and two or more subsystems. This paper deals with the construction and minimality of coordinated linear systems. Construction procedures are given to transform unstructured or interconnected...article 2014
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Smelik, R.M. (author), Tutenel, T. (author), Bidarra, R. (author), Benes, B. (author)Procedural modelling deals with (semi-)automatic content generation by means of a program or procedure. Among other advantages, its data compression and the potential to generate a large variety of detailed content with reduced human intervention, have made procedural modelling attractive for creating virtual environments increasingly used in...article 2014
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Ladirat, S.E. (author), Schoterman, M.H.C. (author), Rahaoui, H. (author), Mars, M. (author), Schuren, F.H.J. (author), Gruppen, H. (author), Nauta, A. (author), Schols, H.A. (author)In the present double-blind, randomised, parallel intervention study, the effects of the intake of galacto-oligosaccharides (GOS) on the gut microbiota of twelve healthy adult subjects (aged 18-45 years with a normal BMI (18-25 kg/m2)) receiving amoxicillin (AMX) treatment were determined. All the subjects were treated with AMX (375 mg; three...article 2014
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Joosten, M.M. (author), Schrieks, I.C. (author), Hendriks, H.F.J. (author)Background: Fetuin-A, a liver-derived glycoprotein that impairs insulin-signalling, has emerged as a biomarker for diabetes risk. Although moderate alcohol consumption has been inversely associated with fetuin-A, data from clinical trials are lacking. Thus, we evaluated whether moderate alcohol consumption decreases circulating levels of fetuin...article 2014
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de Wind, A. (author), Geuskens, G.A. (author), Ybema, J.F. (author), Blatter, B.M. (author), Burdorf, A. (author), Bongers, P.M. (author), van der Beek, A.J. (author)Objectives This study aimed to investigate the relative contribution of health, job characteristics, skills and knowledge, and social and financial factors to the transition from work to (non-disability) early retirement. Methods Employees aged 59–63 years (N=2317) were selected from the Study on Transitions in Employment, Ability and Motivation...article 2014
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Lakerveld, J. (author), van der Ploeg, H.P. (author), Kroezel, W. (author), Ahrens, W. (author), Allais, O. (author), Frost Andersen, L. (author), Cardons, G. (author), Capranica, L. (author), Chastin, S. (author), Donnelly, A. (author), Ekelund, U. (author), Finglash, P. (author), Flechtner-Mors, M. (author), Hebestrei, A. (author), Hendriksen, I. (author), Kubiak, T. (author), Lanza, M. (author), Loyen, A. (author), MacDonncha, C. (author), Mazzocch, M. (author), Monsivais, P. (author), Murphy, M. (author), Nöthlings, U. (author), O’Gorman, D.J. (author), Renner, B. (author), Roos, G. (author), Schuit, A.J. (author), Schulze, M. (author), Steinacker, J. (author), Stronks, K. (author), Volkert, D. (author), van 't Veer, P. (author), Lien, N. (author), de Bourdeaudhuij, I. (author), Brug, J. (author)To address major societal challenges and enhance cooperation in research across Europe, the European Commission has initiated and facilitated ‘joint programming’. Joint programming is a process by which Member States engage in defining, developing and implementing a common strategic research agenda, based on a shared vision of how to address...article 2014
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Scholtes-Timmerman, M.J. (author), Bijlsma, S. (author), Fokkert, M.J. (author), Slingerland, R. (author), van Veen, S.J.F. (author)Self-monitoring of glucose is important for managing diabetes. Noninvasive glucose monitors are not yet available, but patients would benefit highly from such a device. We present results that may lead to a novel, point-of-care noninvasive system to measure blood glucose based on Raman spectroscopy. A hospitalized cohort of 111 subjects was...article 2014
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Wieringa, F.P. (author), Bouma, H. (author), Eendebak, P.T. (author), van Basten, J.P.A. (author), Beerlage, H.P. (author), Smits, G.A.H.J. (author), Bos, J.E. (author)In comparison to open surgery, endoscopic surgery offers impaired depth perception and narrower field-of-view. To improve depth perception, the Da Vinci robot offers three-dimensional (3-D) video on the console for the surgeon but not for assistants, although both must collaborate. We improved the shared perception of the whole surgical team by...article 2014
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Johannsen, H. (author), Adolph, T. (author), Edwards, M. (author), Lazaro, I. (author), Versmissen, A.C.M. (author), Thomson, R. (author), Nederlandse Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek (author), TNO (author)Objective: To improve vehicle safety in frontal collisions, the crash compatibility between the colliding vehicles is crucial. Compatibility aims to improve both the self and partner protection properties of vehicles. Although compatibility has received worldwide attention for many years, no final assessment approach has been defined. Methods:...article 2013
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van Dongen, C.J.G. (author), van Maanen, P.P. (author)This study presents a framework for understanding task and psychological factors affecting reliance on advice from decision aids. The framework describes how informational asymmetries in combination with rational, motivational and heuristic factors explain human reliance behavior. To test hypotheses derived from the framework, 79 participants...article 2013
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von Benda-Beckmann, A.M. (author), Wensveen, P.J. (author), Kvadsheim, P.H. (author), Lam, F.P.A. (author), Miller, P.J.O. (author), Tyack, P.L. (author), Ainslie, M.A. (author)Ramp-up or soft-start procedures (i.e., gradual increase in the source level) are used to mitigate the effect of sonar sound on marine mammals, although no one to date has tested whether ramp-up procedures are effective at reducing the effect of sound on marine mammals. We investigated the effectiveness of ramp-up procedures in reducing the area...article 2013
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Heemskerk, C.J.M. (author), Eendebak, P.T. (author), Schropp, G.Y.R. (author), Hermes, H.V. (author), Elzendoorn, B.S.Q. (author), Magielsen, A.J. (author)Maintenance operations on ITER tokamak components will be largely performed by remote handling. In previous work it was shown that representative maintenance tasks could be performed significantly faster with direct visual feedback than with camera feedback. In post-test interviews, operators indicated that they regarded the lack of 3D...article 2013
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von Benda-Beckmann, A.M. (author), Wensveen, P.J. (author), Kvadsheim, P.H. (author), Lam, F.P.A. (author), Miller, P.J.O. (author), Tyack, P.L. (author), Ainslie, M.A. (author)Ramp-up (or soft-start) procedures are commonly used to mitigate the impact of sound on marine mammals. Although this procedure is often adopted as a common-sense approach, studies that quantify the effectiveness of ramp-up are currently lacking. The effectiveness of ramp-up is investigated by modelling the sound exposure of animals caused by a...conference paper 2013