Searched for: subject:"Priority%5C+journal"
(1 - 20 of 1,118)

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Bezemer, K. (author), McLennan, L. (author), van Duin, L. (author), Kuijpers, C.J. (author), Koeberg, M. (author), van den Elshout, J.J.M.H. (author), van der Heijden, A.E.D.M. (author), Busby, T. (author), Yevdokimov, A. (author), Schoenmakers, P. (author), Smith, J. (author), Oxley, J. (author), van Asten, A. (author)
Erythritol tetranitrate (ETN) was prepared independently by two research groups from the USA and the Netherlands. The partially nitrated impurities present in ETN were studied using liquid chromatography-mass spectrometry to address the ultimate challenge in forensic explosives investigations, i.e., providing chemical and tactical information on...
article 2020
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Offringa, A. (author), Montijn, R. (author), Singh, S. (author), Paul, M. (author), Pinto, Y.M. (author), Pinto-Sietsma, S.J. (author)
The SARS-CoV-2 pandemic is a healthcare crisis caused by insufficient knowledge applicable to effectively combat the virus. Therefore, different scientific discovery strategies need to be connected, to generate a rational treatment which can be made available as rapidly as possible. This relies on a solid theoretical understanding of the...
article 2020
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Sewell, F. (author), Strupp, C. (author), van der Laan, J.W. (author), Wolf, D.C. (author), Wolterink, G. (author), Woutersen, R. (author), Zvonar, Z. (author), Heusinkveld, H. (author), Braakhuis, H. (author)
Currently the only methods for non-genotoxic carcinogenic hazard assessment accepted by most regulatory authorities are lifetime carcinogenicity studies. However, these involve the use of large numbers of animals and the relevance of their predictive power and results has been scientifically challenged. With increased availability of innovative...
article 2020
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van den Dries, M.A. (author), Guxens, M. (author), Spaan, S. (author), Ferguson, K.K. (author), Philips, E. (author), Santos, S. (author), Jaddoe, V.W.V. (author), Ghassabian, A. (author), Trasande, L. (author), Tiemeier, H. (author), Pronk, A. (author)
BACKGROUND: Prenatal exposures to phthalates and bisphenols are associated with impaired brain development in animals. However, epidemiological studies investigating the association between prenatal phthalate or bisphenol exposure and cognition have produced mixed findings and mostly had modest sample sizes and measured the exposure during the...
article 2020
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Fonseca, A.S. (author), Kuijpers, E. (author), Kling, K.I. (author), Levin, M. (author), Koivisto, A.J. (author), Nielsen, S.H. (author), Fransman, W. (author), Fedutik, Y. (author), Jensen, K.A. (author), Koponen, I.K. (author)
Fume hoods are one of the most common types of equipment applied to reduce the potential of particle exposure in laboratory environments. A number of previous studies have shown particle release during work with nanomaterials under fume hoods. Here, we assessed laboratory workers’ inhalation exposure during synthesis and handling of CuO, TiO2...
article 2018
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Reisinger, K. (author), Blatz, V. (author), Brinkmann, J. (author), Downs, T.R. (author), Fischer, A. (author), Henkler, F. (author), Hoffmann, S. (author), Krul, C. (author), Liebsch, M. (author), Luch, A. (author), Pirow, R. (author), Reus, A.A. (author), Schulz, M. (author), Pfuhler, S. (author)
Recently revised OECD Testing Guidelines highlight the importance of considering the first site-of-contact when investigating the genotoxic hazard. Thus far, only in vivo approaches are available to address the dermal route of exposure. The 3D Skin Comet and Reconstructed Skin Micronucleus (RSMN) assays intend to close this gap in the in vitro...
article 2018
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Botschuijver, S. (author), Welting, O. (author), Levin, E. (author), Maria-Ferreira, D. (author), Koch, E. (author), Montijn, R.C. (author), Seppen, J. (author), Hakvoort, T.B.M. (author), Schuren, F.H.J. (author), de Jonge, W.J. (author), van den Wijngaard, R.M. (author)
Background: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder associated with altered gastrointestinal microflora and increased nociception to colonic distension. This visceral hypersensitivity can be reversed in our rat maternal separation model by fungicides. Menthacarin® is a proprietary combination of essential oils from...
article 2018
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Reijnen, A. (author), Geuze, E. (author), Eekhout, I. (author), Maihofer, A.X. (author), Nievergelt, C.M. (author), Baker, D.G. (author), Vermetten, E. (author)
In order to decrease the risk of developing stress-related disorders after military deployment, biological vulnerability factors should be identified. Neuropeptide Y (NPY) is a peptide neurotransmitter that is associated with modulation of the stress response. Using the data of two longitudinal prospective cohort studies (N = 892 and N = 2427),...
article 2018
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Fu, J. (author), van Wietmarschen, H.A. (author), van der Kooij, A. (author), Cuppen, B.V.J. (author), Schroën, Y. (author), Marijnissen, A.K. (author), Meulman, J.J. (author), Lafeber, F.P.J.G. (author), van der Greef, J. (author)
Introduction: Biological therapies have greatly improved the treatment efficacy in rheumatoid arthritis (RA). However, in clinical practice a significant proportion of patients experience an inadequate response to treatment. The aim of this study is to classify responding and non-responding rheumatoid arthritis patients treated with biological...
article 2018
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van der Kleij, R. (author), Hueting, T.F. (author), Schraagen, J.M.C. (author)
Dynamic Positioning (DP) is a computer-controlled process to automatically keep a floating vessel at a specific position or to follow a pre-defined path (tracking) by using its own propellers and thrusters. The human supervisory controller has no direct need to constantly know what the status is of all parts of the automation and the system it...
article 2018
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Tielman, M.L. (author), Neerincx, M.A. (author), van Meggelen, M. (author), Franken, I. (author), Brinkman, W.P. (author)
BACKGROUND AND OBJECTIVE: With the rise of autonomous e-mental health applications, virtual agents can play a major role in improving trustworthiness, therapy outcome and adherence. In these applications, it is important that patients adhere in the sense that they perform the tasks, but also that they adhere to the specific recommendations on...
article 2017
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van Loon, K. (author), Breteler, M.J.M. (author), van Wolfwinkel, L. (author), Rheineck Leyssius, A.T. (author), Kossen, A.S. (author), Kalkman, C.J. (author), van Zaane, B. (author), Peelen, L.M. (author)
Altered respiratory rate is one of the first symptoms of medical conditions that require timely intervention, e.g., sepsis or opioid-induced respiratory depression. To facilitate continuous respiratory rate monitoring on general hospital wards a contactless, non-invasive, prototype monitor was developed using frequency modulated continuous wave...
article 2016
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Fransson, E.I. (author), Nyberg, S.T. (author), Heikkilä, K. (author), Alfredsson, L. (author), Bjorner, J.B. (author), Borritz, M. (author), Burr, H. (author), Dragano, N. (author), Geuskens, G.A. (author), Goldberg, M. (author), Hamer, M. (author), Hooftman, W.E. (author), Houtman, I.L. (author), Joensuu, M. (author), Jokela, M. (author), Knutsson, A. (author), Koskenvuo, M. (author), Koskinen, A. (author), Kumari, M. (author), Leineweber, C. (author), Lunau, T. (author), Madsen, I.E.H. (author), Hanson, L.L.M. (author), Nielsen, M.L. (author), Nordin, M. (author), Oksanen, T. (author), Pentti, J. (author), Pejtersen, J.H. (author), Rugulies, R. (author), Salo, P. (author), Shipley, M.J. (author), Steptoe, A. (author), Suominen, S.B. (author), Theorell, T. (author), Toppinen-Tanner, S. (author), Vahtera, J. (author), Virtanen, M. (author), Väänänen, A. (author), Westerholm, P.J.M. (author), Westerlund, H. (author), Zins, M. (author), Britton, A. (author), Brunner, E.J. (author), Singh-Manoux, A. (author), Batty, G.D. (author), Kivimäki, M. (author)
BACKGROUND AND PURPOSE: Psychosocial stress at work has been proposed to be a risk factor for cardiovascular disease. However, its role as a risk factor for stroke is uncertain. METHODS: We conducted an individual-participant-data meta-analysis of 196 380 males and females from 14 European cohort studies to investigate the association between...
article 2015
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van Avesaat, M. (author), Troost, F.J. (author), Ripken, D. (author), Hendriks, H.F. (author), Aam, M. (author)
BACKGROUND: Activation of the ileal brake, by infusing lipid directly into the distal part of the small intestine, alters gastrointestinal (GI) motility and inhibits food intake. The ileal brake effect on eating behavior of the other macronutrients is currently unknown. OBJECTIVE: The objective of this study was to investigate the effects of...
article 2015
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Taylor, S.L. (author), Houben, G.F. (author), Baumert, J.L. (author), Crevel, R.R.W.R. (author), Allen, K.J. (author), Dubois, A.E.J. (author), Knulst, A.C. (author), Remington, B.C. (author), Kruizinga, A.G. (author), Blom, W.M. (author), Brooke-Taylor, S. (author)
article 2015
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van de Steeg, E. (author), Venhorst, J. (author), Jansen, H.T. (author), Nooijen, I.H.G. (author), Degroot, J. (author), Wortelboer, H.M. (author), Vlaming, M.L.H. (author)
Human organic anion-transporting polypeptide 1B1 (OATP1B1) and OATP1B3 are important hepatic uptake transporters. Early assessment of OATP1B1/1B3-mediated drug-drug interactions (DDIs) is therefore important for successful drug development. A promising approach for early screening and prediction of DDIs is computational modeling. In this study...
article 2015
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Lanting, C.I. (author), van Wouwe, J.P. (author)
article 2015
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Gierman, L.M. (author), Kühnast, S. (author), Koudijs, A. (author), Pieterman, E.J. (author), Kloppenburg, M. (author), van Osch, G.J.V.M. (author), Stojanovic-Susulic, V. (author), Huizinga, T.W.J. (author), Princen, H.M.G. (author), Zuurmond, A.M. (author)
Objective Hypercholesterolaemia, a risk factor for atherosclerosis (ATH), has been suggested to have a role in the development of osteoarthritis (OA). To test this hypothesis, the effect of cholesterol and different cholesterol-lowering treatments on OA was investigated in a mouse model resembling human lipoprotein metabolism. Methods Female...
article 2014
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van Beijsterveldt, A.M. (author), Steffen, K. (author), Stubbe, J.H. (author), Frederiks, J.E. (author), van de Port, I.G.L. (author), Backx, F.J.G. (author)
OBJECTIVE:: To describe characteristics of outdoor soccer injury and recovery among Dutch soccer players. DESIGN:: Prospective cohort study. SETTING:: The 2009-2010 competitive season (33 weeks). PARTICIPANTS:: Four hundred fifty-six Dutch male soccer players of 23 amateur teams. MAIN OUTCOME MEASURES:: Coaches recorded individual exposure to...
article 2014
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Minguillón, M.C. (author), Cirach, M. (author), Hoek, G. (author), Brunekreef, B. (author), Tsai, M. (author), de Hoogh, K. (author), Jedynska, A. (author), Kooter, I.M. (author), Nieuwenhuijsen, M. (author), Querol, X. (author)
Trace and major elements concentrations in PM10 and PM2.5 were measured at 20 sites spread in the Barcelona metropolitan area (1 rural background, 6 urban background, 13 road traffic sites) and at 1 reference site. Three 2-week samples per site and size fraction were collected during 2009 using low volume samplers, adding a total of 120 samples....
article 2014
Searched for: subject:"Priority%5C+journal"
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