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TNO Preventie en Gezondheid (author), Lindahl, U. (author), Li, J.P. (author), Kusche-Gullberg, M. (author), Salmivirta, M. (author), Alaranta, S. (author), Veromaa, T. (author), Emeis, J. (author), Roberts, I. (author), Taylor, C. (author), Oreste, P. (author), Zoppetti, G. (author), Naggi, A. (author), Torri, G. (author), Casu, B. (author)Heparin remains a major drug in prevention of thromboembolic disease. Concerns related to its animal source have prompted search for heparin analogues. The anticoagulant activity of heparin depends on a specific pentasaccharide sequence that binds antithrombin. We report the generation of a product with antithrombin-binding, anticoagulant, and...article 2005
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Hijum, S.A.F.T. (author), Bonting, K. (author), van der Maarel, M.J.E.V. (author), Dijkhuizen, L. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)Fructosyltransferase (FTF) enzymes have been characterized from various Gram-positive bacteria, but not from Lactobacillus sp. In a screening of 182 lactobacilli for polysaccharide production only one strain, Lactobacillus reuteri strain 121, was found to produce a fructan being a levan. Here we report the first-time identification and...article 2001