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TNO Preventie en Gezondheid (author), Lindahl, U. (author), Li, J.P. (author), Kusche-Gullberg, M. (author), Salmivirta, M. (author), Alaranta, S. (author), Veromaa, T. (author), Emeis, J. (author), Roberts, I. (author), Taylor, C. (author), Oreste, P. (author), Zoppetti, G. (author), Naggi, A. (author), Torri, G. (author), Casu, B. (author)
Heparin remains a major drug in prevention of thromboembolic disease. Concerns related to its animal source have prompted search for heparin analogues. The anticoagulant activity of heparin depends on a specific pentasaccharide sequence that binds antithrombin. We report the generation of a product with antithrombin-binding, anticoagulant, and...
article 2005
Hijum, S.A.F.T. (author), Bonting, K. (author), van der Maarel, M.J.E.V. (author), Dijkhuizen, L. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Fructosyltransferase (FTF) enzymes have been characterized from various Gram-positive bacteria, but not from Lactobacillus sp. In a screening of 182 lactobacilli for polysaccharide production only one strain, Lactobacillus reuteri strain 121, was found to produce a fructan being a levan. Here we report the first-time identification and...
article 2001